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Melt electrowriting of a photo-crosslinkable poly(epsilon-caprolactone)-based material into tubular constructs with predefined architecture and tunable mechanical properties

Nele Pien (UGent) , Michael Bartolf-Kopp, Laurens Parmentier (UGent) , Jasper Delaey, Lobke De Vos (UGent) , Diego Mantovani, Sandra Van Vlierberghe (UGent) , Peter Dubruel (UGent) and Tomasz Jungst
(2022) MACROMOLECULAR MATERIALS AND ENGINEERING. 307(7).
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Abstract
Melt electrowriting (MEW) is an additive manufacturing process that produces highly defined constructs with elements in the micrometer range. A specific configuration of MEW enables printing tubular constructs to create small-diameter tubular structures. The small pool of processable materials poses a bottleneck for wider application in biomedicine. To alleviate this obstacle, an acrylate-endcapped urethane-based polymer (AUP), using a poly(epsilon-caprolactone) (PCL) (molar mass: 20 000 g mol(-1)) (AUP PCL20k) as backbone material, is synthesized and utilized for MEW. Spectroscopic analysis confirms the successful modification of the PCL backbone with photo-crosslinkable acrylate endgroups. Printing experiments of AUP PCL20k reveal limited printability but the photo-crosslinking ability is preserved post-printing. To improve printability and to tune the mechanical properties of printed constructs, the AUP-material is blended with commercially available PCL (AUP PCL20k:PCL in ratios 80:20, 60:40, 50:50). Print fidelity improves for 60:40 and 50:50 blends. Blending enables modification of the constructs' mechanical properties to approximate the range of blood vessels for transplantation surgeries. The crosslinking-ability of the material allows pure AUP to be manipulated post-printing and illustrates significant differences in mechanical properties of 80:20 blends after crosslinking. An in vitro cell compatibility assay using human umbilical vein endothelial cells also demonstrates the material's non-cytotoxicity.
Keywords
BIODEGRADABLE POLYMERS, MOLECULAR-WEIGHT, FABRICATION, MORPHOLOGY, DESIGN, VEIN, PCL, acrylate-endcapped urethane-based polymer (AUP), melt electrowriting, (MEW), photo-crosslinking, physicochemical characterization, tubular, constructs

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MLA
Pien, Nele, et al. “Melt Electrowriting of a Photo-Crosslinkable Poly(Epsilon-Caprolactone)-Based Material into Tubular Constructs with Predefined Architecture and Tunable Mechanical Properties.” MACROMOLECULAR MATERIALS AND ENGINEERING, vol. 307, no. 7, 2022, doi:10.1002/mame.202200097.
APA
Pien, N., Bartolf-Kopp, M., Parmentier, L., Delaey, J., De Vos, L., Mantovani, D., … Jungst, T. (2022). Melt electrowriting of a photo-crosslinkable poly(epsilon-caprolactone)-based material into tubular constructs with predefined architecture and tunable mechanical properties. MACROMOLECULAR MATERIALS AND ENGINEERING, 307(7). https://doi.org/10.1002/mame.202200097
Chicago author-date
Pien, Nele, Michael Bartolf-Kopp, Laurens Parmentier, Jasper Delaey, Lobke De Vos, Diego Mantovani, Sandra Van Vlierberghe, Peter Dubruel, and Tomasz Jungst. 2022. “Melt Electrowriting of a Photo-Crosslinkable Poly(Epsilon-Caprolactone)-Based Material into Tubular Constructs with Predefined Architecture and Tunable Mechanical Properties.” MACROMOLECULAR MATERIALS AND ENGINEERING 307 (7). https://doi.org/10.1002/mame.202200097.
Chicago author-date (all authors)
Pien, Nele, Michael Bartolf-Kopp, Laurens Parmentier, Jasper Delaey, Lobke De Vos, Diego Mantovani, Sandra Van Vlierberghe, Peter Dubruel, and Tomasz Jungst. 2022. “Melt Electrowriting of a Photo-Crosslinkable Poly(Epsilon-Caprolactone)-Based Material into Tubular Constructs with Predefined Architecture and Tunable Mechanical Properties.” MACROMOLECULAR MATERIALS AND ENGINEERING 307 (7). doi:10.1002/mame.202200097.
Vancouver
1.
Pien N, Bartolf-Kopp M, Parmentier L, Delaey J, De Vos L, Mantovani D, et al. Melt electrowriting of a photo-crosslinkable poly(epsilon-caprolactone)-based material into tubular constructs with predefined architecture and tunable mechanical properties. MACROMOLECULAR MATERIALS AND ENGINEERING. 2022;307(7).
IEEE
[1]
N. Pien et al., “Melt electrowriting of a photo-crosslinkable poly(epsilon-caprolactone)-based material into tubular constructs with predefined architecture and tunable mechanical properties,” MACROMOLECULAR MATERIALS AND ENGINEERING, vol. 307, no. 7, 2022.
@article{8754707,
  abstract     = {{Melt electrowriting (MEW) is an additive manufacturing process that produces highly defined constructs with elements in the micrometer range. A specific configuration of MEW enables printing tubular constructs to create small-diameter tubular structures. The small pool of processable materials poses a bottleneck for wider application in biomedicine. To alleviate this obstacle, an acrylate-endcapped urethane-based polymer (AUP), using a poly(epsilon-caprolactone) (PCL) (molar mass: 20 000 g mol(-1)) (AUP PCL20k) as backbone material, is synthesized and utilized for MEW. Spectroscopic analysis confirms the successful modification of the PCL backbone with photo-crosslinkable acrylate endgroups. Printing experiments of AUP PCL20k reveal limited printability but the photo-crosslinking ability is preserved post-printing. To improve printability and to tune the mechanical properties of printed constructs, the AUP-material is blended with commercially available PCL (AUP PCL20k:PCL in ratios 80:20, 60:40, 50:50). Print fidelity improves for 60:40 and 50:50 blends. Blending enables modification of the constructs' mechanical properties to approximate the range of blood vessels for transplantation surgeries. The crosslinking-ability of the material allows pure AUP to be manipulated post-printing and illustrates significant differences in mechanical properties of 80:20 blends after crosslinking. An in vitro cell compatibility assay using human umbilical vein endothelial cells also demonstrates the material's non-cytotoxicity.}},
  articleno    = {{2200097}},
  author       = {{Pien, Nele and Bartolf-Kopp, Michael and Parmentier, Laurens and Delaey, Jasper and De Vos, Lobke and Mantovani, Diego and Van Vlierberghe, Sandra and Dubruel, Peter and Jungst, Tomasz}},
  issn         = {{1438-7492}},
  journal      = {{MACROMOLECULAR MATERIALS AND ENGINEERING}},
  keywords     = {{BIODEGRADABLE POLYMERS,MOLECULAR-WEIGHT,FABRICATION,MORPHOLOGY,DESIGN,VEIN,PCL,acrylate-endcapped urethane-based polymer (AUP),melt electrowriting,(MEW),photo-crosslinking,physicochemical characterization,tubular,constructs}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{15}},
  title        = {{Melt electrowriting of a photo-crosslinkable poly(epsilon-caprolactone)-based material into tubular constructs with predefined architecture and tunable mechanical properties}},
  url          = {{http://doi.org/10.1002/mame.202200097}},
  volume       = {{307}},
  year         = {{2022}},
}
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