@article{8754442,
  abstract     = {{Patients with acute myeloid leukemia (AML) are at high risk of dying from coronavirus disease 2019 (COVID-19). The optimal management of AML patients with COVID-19 has not been established. Our multicenter study included 388 adult AML patients diagnosed with COVID-19 between February 2020 and October 2021. The vast majority were receiving or had received AML treatment in the preceding 3 months. COVID-19 was severe in 41.2% and critical in 21.1% of cases. The chemotherapeutic schedule was modified in 174 patients (44.8%), delayed in 68 and permanently discontinued in 106. After a median follow-up of 325 days, 180 patients (46.4%) had died; death was attributed to COVID-19 (43.3%), AML (26.1%) or to a combination of both (26.7%), whereas in 3.9% of cases the reason was unknown. Active disease, older age, and treatment discontinuation were associated with death, whereas AML treatment delay was protective. Seventy-nine patients had a simultaneous AML and COVID-19 diagnosis, with better survival when AML treatment could be delayed (80%; P<0.001). Overall survival in patients with a diagnosis of COVID-19 between January 2020 and August 2020 was significantly lower than that in patients diagnosed between September 2020 and February 2021 and between March 2021 and September 2021 (39.8% vs. 60% vs. 61.9%, respectively; P=0.006). COVID-19 in AML patients was associated with a high mortality rate and modifications of therapeutic algorithms. The best approach to improve survival was to delay AML treatment, whenever possible.}},
  author       = {{Marchesi, Francesco and Salmanton-García, Jon and Emarah, Ziad and Piukovics, Klára and Nucci, Marcio and López-García, Alberto and Ráčil, Zdeněk and Farina, Francesca and Popova, Marina and Zompi, Sofia and Audisio, Ernesta and Ledoux, Marie-Pierre and Verga, Luisa and Weinbergerová, Barbora and Szotkovski, Tomas and Da Silva, Maria Gomes and Fracchiolla, Nicola and De Jonge, Nick and Collins, Graham and Marchetti, Monia and Magliano, Gabriele and García-Vidal, Carolina and Biernat, Monika M. and Van Doesum, Jaap and Machado, Marina and Demirkan, Fatih and Al-Khabori, Murtadha and Žák, Pavel and Víšek, Benjamín and Stoma, Igor and Méndez, Gustavo-Adolfo and Maertens, Johan and Khanna, Nina and Espigado, Ildefonso and Dragonetti, Giulia and Fianchi, Luana and Del Principe, Maria Ilaria and Cabirta, Alba and Ormazabal-Vélez, Irati and Jaksic, Ozren and Buquicchio, Caterina and Bonuomo, Valentina and Batinić, Josip and Omrani, Ali S. and Lamure, Sylvain and Finizio, Olimpia and Fernández, Noemí and Falces-Romero, Iker and Blennow, Ola and Bergantim, Rui and Ali, Natasha and Win, Sein and Van Praet, Jens and Tisi, Maria Chiara and Shirinova, Ayten and Schönlein, Martin and Prattes, Juergen and Piedimonte, Monica and Petzer, Verena and Navrátil, Milan and Kulasekararaj, Austin and Jindra, Pavel and Sramek, Jiří and Glenthøj, Andreas and Fazzi, Rita and De Ramón-Sánchez, Cristina and Cattaneo, Chiara and Calbacho, Maria and Bahr, Nathan C. and El-Ashwah, Shaimaa and Cordoba, Raul and Hanakova, Michaela and Zambrotta, Giovanni and Sciumè, Mariarita and Booth, Stephen and Rodrigues, Raquel Nunes and Sacchi, Maria Vittoria and García-Poutón, Nicole and Martín-González, Juan-Alberto and Khostelidi, Sofya and Gräfe, Stefanie and Rahimli, Laman and Ammatuna, Emanuele and Busca, Alessandro and Corradini, Paolo and Hoenigl, Martin and Klimko, Nikolai and Koehler, Philipp and Pagliuca, Antonio and Passamonti, Francesco and Cornely, Oliver A. and Pagano, Livio}},
  issn         = {{0390-6078}},
  journal      = {{HAEMATOLOGICA}},
  keywords     = {{Hematology}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{22--33}},
  title        = {{COVID-19 in adult acute myeloid leukemia patients : a long-term followup study from the European Hematology Association survey (EPICOVIDEHA)}},
  url          = {{http://doi.org/10.3324/haematol.2022.280847}},
  volume       = {{108}},
  year         = {{2023}},
}

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