@article{8753171,
  abstract     = {{Species belonging to the order Ranunculales have attracted much attention because of their phylogenetic position as a sister group to all other eudicot lineages and their ability to produce unique yet diverse benzylisoquinoline alkaloids (BIAs). The Papaveraceae family in Ranunculales is often used as a model system for studying BIA biosynthesis. Here, we report the chromosome-level genome assembly of Corydalis tomentella, a species of Fumarioideae-one of the two subfamilies of Papaveraceae. Based on the comparisons of sequenced Ranunculalean species, we present clear evidence of a shared whole-genome duplication (WGD) event that has occurred before the divergence of Ranunculales but after its divergence from other eudicot lineages. The C. tomentella genome enabled us to integrate isotopic labelling and comparative genomics to reconstruct the BIA biosynthetic pathway for both sanguinarine biosynthesis shared by papaveraceous species and the cavidine biosynthesis specific to Corydalis. Also, our comparative analysis revealed that gene duplications, especially tandem gene duplications, underlie the diversification of BIA biosynthetic pathways in Ranunculales. In particular, tandemly duplicated berberine bridge enzyme-like genes appear to be involved in cavidine biosynthesis. In conclusion, our study of the C. tomentella genome provides important insights into the occurrence of WGDs during the early evolution of eudicots as well as into the evolution of BIA biosynthesis in Ranunculales.}},
  author       = {{Xu, Zhichao and Li, Zhen and Ren, Fengming and Gao, Ranran and Wang, Zhe and Zhang, Jinlan and Zhao, Tao and Ma, Xiao and Pu, Xiangdong and Xin, Tianyi and Rombauts, Stephane and Sun, Wei and Van de Peer, Yves and Chen, Shilin and Song, Jingyuan}},
  issn         = {{0960-7412}},
  journal      = {{PLANT JOURNAL}},
  keywords     = {{Corydalis tomentella,Papaveraceae,benzylisoquinoline alkaloids,evolution,whole-genome duplication,Plant Science,Genetics,benzylisoquinoline alkaloids,Papaveraceae,Corydalis tomentella,whole-genome duplication,evolution,MICROBIAL-PRODUCTION,SEQUENCE,PLANT,DNA,PAPAVERACEAE,PROVIDES,FAMILY,GENE,TOOL}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{217--230}},
  title        = {{The genome of Corydalis reveals the evolution of benzylisoquinoline alkaloid biosynthesis in Ranunculales}},
  url          = {{http://doi.org/10.1111/tpj.15788}},
  volume       = {{111}},
  year         = {{2022}},
}

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