Which cell death modality wins the contest for photodynamic therapy of cancer?
- Author
- Tatiana Mishchenko, Irina Balalaeva, Anastasia Gorokhova, Maria Vedunova and Dmitri Krysko (UGent)
- Organization
- Abstract
- Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed for the treatment of several types of cancer. Traditionally, cell death induced by PDT was categorized into three types: apoptosis, cell death associated with autophagy, and necrosis. However, with the discovery of several other regulated cell death modalities in recent years, it has become clear that this is a rather simple understanding of the mechanisms of action of PDT. New observations revealed that cancer cells exposed to PDT can pass through various non-conventional cell death pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, and ferroptosis. Nowadays, immunogenic cell death (ICD) has become one of the most promising ways to eradicate tumor cells by activation of the T-cell adaptive immune response and induction of long-term immunological memory. ICD can be triggered by many anti-cancer treatment methods, including PDT. In this review, we critically discuss recent findings on the non-conventional cell death mechanisms triggered by PDT. Next, we emphasize the role and contribution of ICD in these PDT-induced non-conventional cell death modalities. Finally, we discuss the obstacles and propose several areas of research that will help to overcome these challenges and lead to the development of highly effective anti-cancer therapy based on PDT.
- Keywords
- Cancer Research, Photodynamic Therapy, Immunogenic Cell Death, Cell Death, Cellular and Molecular Neuroscience, MITOTIC CATASTROPHE, LUNG-CANCER, INFLAMMATORY RESPONSE, PHOTOSENSITIZER DTPP, EFFICIENT APOPTOSIS, NLRP3 INFLAMMASOME, INDUCE PYROPTOSIS, GENE-EXPRESSION, GASDERMIN D, MECHANISMS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8752913
- MLA
- Mishchenko, Tatiana, et al. “Which Cell Death Modality Wins the Contest for Photodynamic Therapy of Cancer?” CELL DEATH & DISEASE, vol. 13, no. 5, 2022, doi:10.1038/s41419-022-04851-4.
- APA
- Mishchenko, T., Balalaeva, I., Gorokhova, A., Vedunova, M., & Krysko, D. (2022). Which cell death modality wins the contest for photodynamic therapy of cancer? CELL DEATH & DISEASE, 13(5). https://doi.org/10.1038/s41419-022-04851-4
- Chicago author-date
- Mishchenko, Tatiana, Irina Balalaeva, Anastasia Gorokhova, Maria Vedunova, and Dmitri Krysko. 2022. “Which Cell Death Modality Wins the Contest for Photodynamic Therapy of Cancer?” CELL DEATH & DISEASE 13 (5). https://doi.org/10.1038/s41419-022-04851-4.
- Chicago author-date (all authors)
- Mishchenko, Tatiana, Irina Balalaeva, Anastasia Gorokhova, Maria Vedunova, and Dmitri Krysko. 2022. “Which Cell Death Modality Wins the Contest for Photodynamic Therapy of Cancer?” CELL DEATH & DISEASE 13 (5). doi:10.1038/s41419-022-04851-4.
- Vancouver
- 1.Mishchenko T, Balalaeva I, Gorokhova A, Vedunova M, Krysko D. Which cell death modality wins the contest for photodynamic therapy of cancer? CELL DEATH & DISEASE. 2022;13(5).
- IEEE
- [1]T. Mishchenko, I. Balalaeva, A. Gorokhova, M. Vedunova, and D. Krysko, “Which cell death modality wins the contest for photodynamic therapy of cancer?,” CELL DEATH & DISEASE, vol. 13, no. 5, 2022.
@article{8752913,
abstract = {{Photodynamic therapy (PDT) was discovered more than 100 years ago. Since then, many protocols and agents for PDT have been proposed for the treatment of several types of cancer. Traditionally, cell death induced by PDT was categorized into three types: apoptosis, cell death associated with autophagy, and necrosis. However, with the discovery of several other regulated cell death modalities in recent years, it has become clear that this is a rather simple understanding of the mechanisms of action of PDT. New observations revealed that cancer cells exposed to PDT can pass through various non-conventional cell death pathways, such as paraptosis, parthanatos, mitotic catastrophe, pyroptosis, necroptosis, and ferroptosis. Nowadays, immunogenic cell death (ICD) has become one of the most promising ways to eradicate tumor cells by activation of the T-cell adaptive immune response and induction of long-term immunological memory. ICD can be triggered by many anti-cancer treatment methods, including PDT. In this review, we critically discuss recent findings on the non-conventional cell death mechanisms triggered by PDT. Next, we emphasize the role and contribution of ICD in these PDT-induced non-conventional cell death modalities. Finally, we discuss the obstacles and propose several areas of research that will help to overcome these challenges and lead to the development of highly effective anti-cancer therapy based on PDT.}},
articleno = {{455}},
author = {{Mishchenko, Tatiana and Balalaeva, Irina and Gorokhova, Anastasia and Vedunova, Maria and Krysko, Dmitri}},
issn = {{2041-4889}},
journal = {{CELL DEATH & DISEASE}},
keywords = {{Cancer Research,Photodynamic Therapy,Immunogenic Cell Death,Cell Death,Cellular and Molecular Neuroscience,MITOTIC CATASTROPHE,LUNG-CANCER,INFLAMMATORY RESPONSE,PHOTOSENSITIZER DTPP,EFFICIENT APOPTOSIS,NLRP3 INFLAMMASOME,INDUCE PYROPTOSIS,GENE-EXPRESSION,GASDERMIN D,MECHANISMS}},
language = {{eng}},
number = {{5}},
pages = {{16}},
title = {{Which cell death modality wins the contest for photodynamic therapy of cancer?}},
url = {{http://doi.org/10.1038/s41419-022-04851-4}},
volume = {{13}},
year = {{2022}},
}
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