Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 734.24 KB
Add to list
  1. Search results
  2. Short-term mortality of patients ≥80 ...

Short-term mortality of patients ≥80 years old admitted to European intensive care units : an international observational study

Jakub Fronczek, Hans Flaatten, Bertrand Guidet, Kamil Polok, Finn H. Andersen, Benjamin Y. Andrew, Antonio Artigas, Michael Beil, Maurizio Cecconi, Steffen Christensen, et al.
(2022) BRITISH JOURNAL OF ANAESTHESIA. 129(1). p.58-66
Author
Organization
Abstract
Background: Limited evidence suggests variation in mortality of older critically ill adults across Europe. We aimed to investigate regional differences in mortality among very old ICU patients. Methods: Multilevel analysis of two international prospective cohort studies. We included patients >= 80 yr old from 322 ICUs located in 16 European countries. The primary outcome was mortality within 30 days from admission to the ICU. Results are presented as n (%) with 95% confidence intervals and odds ratios (ORs). Results: Of 8457 patients, 2944 (36.9% [35.9-38.0%]) died within 30 days. Crude mortality rates varied widely between participating countries (from 10.1% [6.4-15.6%] to 45.1% [41.1-49.2%] in the ICU and from 21.3% [16.3-28.9%] to 55.3% [51.1-59.5%] within 30 days). After adjustment for confounding variables, the variation in 30-day mortality between countries was substantially smaller than between ICUs (median OR 1.14 vs 1.58). Healthcare expenditure per capita (OR=0.84 per $1000 [0.75-0.94]) and social health insurance framework (OR=1.43 [1.01-2.01]) were associated with ICU mortality, but the direction and magnitude of these relationships was uncertain in 30-day follow-up. Volume of admissions was associated with lower mortality both in the ICU (OR=0.81 per 1000 annual ICU admissions [0.71-0.94]) and in 30-day follow-up (OR=0.86 [0.76-0.97]). Conclusion: The apparent variation in short-term mortality rates of older adults hospitalised in ICUs across Europe can be largely attributed to differences in the clinical profile of patients admitted. The volume-outcome relationship identified in this population requires further investigation.
Keywords
Anesthesiology and Pain Medicine, cohort studies, critical care outcomes, critical illness, Europe, intensive care unit, mortality, old patients, outcome assessment, variation, ELDERLY-PATIENTS, QUALITY, ICU, FRAILTY, SEPSIS, COST

Downloads

  • Download
    (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 734.24 KB

Citation

Please use this url to cite or link to this publication:

MLA
Fronczek, Jakub, et al. “Short-Term Mortality of Patients ≥80 Years Old Admitted to European Intensive Care Units : An International Observational Study.” BRITISH JOURNAL OF ANAESTHESIA, vol. 129, no. 1, 2022, pp. 58–66, doi:10.1016/j.bja.2022.03.026.
APA
Fronczek, J., Flaatten, H., Guidet, B., Polok, K., Andersen, F. H., Andrew, B. Y., … Szczeklik, W. (2022). Short-term mortality of patients ≥80 years old admitted to European intensive care units : an international observational study. BRITISH JOURNAL OF ANAESTHESIA, 129(1), 58–66. https://doi.org/10.1016/j.bja.2022.03.026
Chicago author-date
Fronczek, Jakub, Hans Flaatten, Bertrand Guidet, Kamil Polok, Finn H. Andersen, Benjamin Y. Andrew, Antonio Artigas, et al. 2022. “Short-Term Mortality of Patients ≥80 Years Old Admitted to European Intensive Care Units : An International Observational Study.” BRITISH JOURNAL OF ANAESTHESIA 129 (1): 58–66. https://doi.org/10.1016/j.bja.2022.03.026.
Chicago author-date (all authors)
Fronczek, Jakub, Hans Flaatten, Bertrand Guidet, Kamil Polok, Finn H. Andersen, Benjamin Y. Andrew, Antonio Artigas, Michael Beil, Maurizio Cecconi, Steffen Christensen, Dylan W. de Lange, Jesper Fjølner, Jacek Górka, Michael Joannidis, Christian Jung, Krzysztof Kusza, Susannah Leaver, Brian Marsh, Alessandro Morandi, Rui Moreno, Sandra Oeyen, Radosław Owczuk, Christina Agvald-Öhman, Bernardo B. Pinto, Andrew Rhodes, Joerg C. Schefold, Ivo W. Soliman, Andreas Valentin, Sten Walther, Ximena Watson, Tilemachos Zafeiridis, and Wojciech Szczeklik. 2022. “Short-Term Mortality of Patients ≥80 Years Old Admitted to European Intensive Care Units : An International Observational Study.” BRITISH JOURNAL OF ANAESTHESIA 129 (1): 58–66. doi:10.1016/j.bja.2022.03.026.
Vancouver
1.
Fronczek J, Flaatten H, Guidet B, Polok K, Andersen FH, Andrew BY, et al. Short-term mortality of patients ≥80 years old admitted to European intensive care units : an international observational study. BRITISH JOURNAL OF ANAESTHESIA. 2022;129(1):58–66.
IEEE
[1]
J. Fronczek et al., “Short-term mortality of patients ≥80 years old admitted to European intensive care units : an international observational study,” BRITISH JOURNAL OF ANAESTHESIA, vol. 129, no. 1, pp. 58–66, 2022.
@article{8751639,
  abstract     = {{Background: Limited evidence suggests variation in mortality of older critically ill adults across Europe. We aimed to investigate regional differences in mortality among very old ICU patients.

Methods: Multilevel analysis of two international prospective cohort studies. We included patients >= 80 yr old from 322 ICUs located in 16 European countries. The primary outcome was mortality within 30 days from admission to the ICU. Results are presented as n (%) with 95% confidence intervals and odds ratios (ORs).

Results: Of 8457 patients, 2944 (36.9% [35.9-38.0%]) died within 30 days. Crude mortality rates varied widely between participating countries (from 10.1% [6.4-15.6%] to 45.1% [41.1-49.2%] in the ICU and from 21.3% [16.3-28.9%] to 55.3% [51.1-59.5%] within 30 days). After adjustment for confounding variables, the variation in 30-day mortality between countries was substantially smaller than between ICUs (median OR 1.14 vs 1.58). Healthcare expenditure per capita (OR=0.84 per $1000 [0.75-0.94]) and social health insurance framework (OR=1.43 [1.01-2.01]) were associated with ICU mortality, but the direction and magnitude of these relationships was uncertain in 30-day follow-up. Volume of admissions was associated with lower mortality both in the ICU (OR=0.81 per 1000 annual ICU admissions [0.71-0.94]) and in 30-day follow-up (OR=0.86 [0.76-0.97]).

Conclusion: The apparent variation in short-term mortality rates of older adults hospitalised in ICUs across Europe can be largely attributed to differences in the clinical profile of patients admitted. The volume-outcome relationship identified in this population requires further investigation.}},
  author       = {{Fronczek, Jakub and Flaatten, Hans and Guidet, Bertrand and Polok, Kamil and Andersen, Finn H. and Andrew, Benjamin Y. and Artigas, Antonio and Beil, Michael and Cecconi, Maurizio and Christensen, Steffen and de Lange, Dylan W. and Fjølner, Jesper and Górka, Jacek and Joannidis, Michael and Jung, Christian and Kusza, Krzysztof and Leaver, Susannah and Marsh, Brian and Morandi, Alessandro and Moreno, Rui and Oeyen, Sandra and Owczuk, Radosław and Agvald-Öhman, Christina and Pinto, Bernardo B. and Rhodes, Andrew and Schefold, Joerg C. and Soliman, Ivo W. and Valentin, Andreas and Walther, Sten and Watson, Ximena and Zafeiridis, Tilemachos and Szczeklik, Wojciech}},
  issn         = {{0007-0912}},
  journal      = {{BRITISH JOURNAL OF ANAESTHESIA}},
  keywords     = {{Anesthesiology and Pain Medicine,cohort studies,critical care outcomes,critical illness,Europe,intensive care unit,mortality,old patients,outcome assessment,variation,ELDERLY-PATIENTS,QUALITY,ICU,FRAILTY,SEPSIS,COST}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{58--66}},
  title        = {{Short-term mortality of patients ≥80 years old admitted to European intensive care units : an international observational study}},
  url          = {{http://doi.org/10.1016/j.bja.2022.03.026}},
  volume       = {{129}},
  year         = {{2022}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: