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Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela

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Abstract
BackgroundFollowing earlier trials indicating that their potential in dengue vector control was constrained by housing structure, a large-scale cluster-randomized trial of insecticide treated curtains (ITCs) and water jar covers (ITJCs) was undertaken in Venezuela.MethodsIn Trujillo, Venezuela, 60 clusters (6223 houses total) were randomized so that 15 clusters each received either PermaNet insecticide-treated window curtains (ITCs), permanent insecticide-treated water storage jar covers (ITJCs), a combination of both ITCs and ITJCs, or no insecticide treated materials (ITMs). A further 15 clusters located at least 5km from the edge of the study site were selected to act as an external control. Entomological surveys were carried out immediately before and after intervention, and then at 6-month intervals over the following 27 months. The Breteau and House indices were used as primary outcome measures and ovitrap indices as secondary. Negative binomial regression models were used to compare cluster-level values of these indices between the trial arms.ResultsReductions in entomological indices followed deployment of all ITMs and throughout the trial, indices in the external control arm remained substantially higher than in the ITM study arms including the internal control. Comparing the ratios of between-arm means to summarise the entomological indices throughout the study, the combined ITC+ITJC intervention had the greatest impact on the indices, with a 63% difference in the pupae per person indices between the ITC+ITJC arm and the internal control. However, coverage had fallen below 60% by 14-months post-intervention and remained below 40% for most of the remaining study period.ConclusionsITMs can impact dengue vector populations in the long term, particularly when ITCs and ITJCs are deployed in combination.
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AEDES-AEGYPTI

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MLA
Lenhart, Audrey, et al. “Evaluation of Insecticide Treated Window Curtains and Water Container Covers for Dengue Vector Control in a Large-Scale Cluster-Randomized Trial in Venezuela.” PLOS NEGLECTED TROPICAL DISEASES, vol. 16, no. 3, 2022, doi:10.1371/journal.pntd.0010135.
APA
Lenhart, A., Castillo, C. E., Villegas, E., Alexander, N., Vanlerberghe, V., Van Der Stuyft, P., & McCall, P. S. (2022). Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela. PLOS NEGLECTED TROPICAL DISEASES, 16(3). https://doi.org/10.1371/journal.pntd.0010135
Chicago author-date
Lenhart, Audrey, Carmen Elena Castillo, Elci Villegas, Neal Alexander, Veerle Vanlerberghe, Patrick Van Der Stuyft, and Philip S. McCall. 2022. “Evaluation of Insecticide Treated Window Curtains and Water Container Covers for Dengue Vector Control in a Large-Scale Cluster-Randomized Trial in Venezuela.” PLOS NEGLECTED TROPICAL DISEASES 16 (3). https://doi.org/10.1371/journal.pntd.0010135.
Chicago author-date (all authors)
Lenhart, Audrey, Carmen Elena Castillo, Elci Villegas, Neal Alexander, Veerle Vanlerberghe, Patrick Van Der Stuyft, and Philip S. McCall. 2022. “Evaluation of Insecticide Treated Window Curtains and Water Container Covers for Dengue Vector Control in a Large-Scale Cluster-Randomized Trial in Venezuela.” PLOS NEGLECTED TROPICAL DISEASES 16 (3). doi:10.1371/journal.pntd.0010135.
Vancouver
1.
Lenhart A, Castillo CE, Villegas E, Alexander N, Vanlerberghe V, Van Der Stuyft P, et al. Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela. PLOS NEGLECTED TROPICAL DISEASES. 2022;16(3).
IEEE
[1]
A. Lenhart et al., “Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela,” PLOS NEGLECTED TROPICAL DISEASES, vol. 16, no. 3, 2022.
@article{8751245,
  abstract     = {{BackgroundFollowing earlier trials indicating that their potential in dengue vector control was constrained by housing structure, a large-scale cluster-randomized trial of insecticide treated curtains (ITCs) and water jar covers (ITJCs) was undertaken in Venezuela.MethodsIn Trujillo, Venezuela, 60 clusters (6223 houses total) were randomized so that 15 clusters each received either PermaNet insecticide-treated window curtains (ITCs), permanent insecticide-treated water storage jar covers (ITJCs), a combination of both ITCs and ITJCs, or no insecticide treated materials (ITMs). A further 15 clusters located at least 5km from the edge of the study site were selected to act as an external control. Entomological surveys were carried out immediately before and after intervention, and then at 6-month intervals over the following 27 months. The Breteau and House indices were used as primary outcome measures and ovitrap indices as secondary. Negative binomial regression models were used to compare cluster-level values of these indices between the trial arms.ResultsReductions in entomological indices followed deployment of all ITMs and throughout the trial, indices in the external control arm remained substantially higher than in the ITM study arms including the internal control. Comparing the ratios of between-arm means to summarise the entomological indices throughout the study, the combined ITC+ITJC intervention had the greatest impact on the indices, with a 63% difference in the pupae per person indices between the ITC+ITJC arm and the internal control. However, coverage had fallen below 60% by 14-months post-intervention and remained below 40% for most of the remaining study period.ConclusionsITMs can impact dengue vector populations in the long term, particularly when ITCs and ITJCs are deployed in combination.}},
  articleno    = {{e0010135}},
  author       = {{Lenhart, Audrey and Castillo, Carmen Elena and Villegas, Elci and Alexander, Neal and Vanlerberghe, Veerle and Van Der Stuyft, Patrick and McCall, Philip S.}},
  issn         = {{1935-2735}},
  journal      = {{PLOS NEGLECTED TROPICAL DISEASES}},
  keywords     = {{AEDES-AEGYPTI}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{16}},
  title        = {{Evaluation of insecticide treated window curtains and water container covers for dengue vector control in a large-scale cluster-randomized trial in Venezuela}},
  url          = {{http://doi.org/10.1371/journal.pntd.0010135}},
  volume       = {{16}},
  year         = {{2022}},
}

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