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Hard, soft, and hard-and-soft drug delivery carriers based on CaCO3 and alginate biomaterials : synthesis, properties, pharmaceutical applications

Yanqi Huang (UGent) , Lin Cao (UGent) , Bogdan Parakhonskiy (UGent) and Andre Skirtach (UGent)
(2022) PHARMACEUTICS. 14(5).
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Abstract
Because free therapeutic drug molecules often have adverse effects on normal tissues, deliver scanty drug concentrations and exhibit a potentially low efficacy at pathological sites, various drug carriers have been developed for preclinical and clinical trials. Their physicochemical and toxicological properties are the subject of extensive research. Inorganic calcium carbonate particles are promising candidates as drug delivery carriers owning to their hardness, porous internal structure, high surface area, distinctive pH-sensitivity, low degradability, etc, while soft organic alginate hydrogels are also widely used because of their special advantages such as a high hydration, bio-adhesiveness, and non-antigenicity. Here, we review these two distinct substances as well as hybrid structures encompassing both types of carriers. Methods of their synthesis, fundamental properties and mechanisms of formation, and their respective applications are described. Furthermore, we summarize and compare similarities versus differences taking into account unique advantages and disadvantages of these drug delivery carriers. Moreover, rational combination of both carrier types due to their performance complementarity (yin-&yang properties: in general, yin is referred to for definiteness as hard, and yang is broadly taken as soft) is proposed to be used in the so-called hybrid carriers endowing them with even more advanced properties envisioned to be attractive for designing new drug delivery systems.
Keywords
Pharmaceutical Science, calcium carbonate, alginate hydrogels, drug delivery, drug loading, release mechanism, CALCIUM-CARBONATE MICROPARTICLES, CORE-SHELL NANOPARTICLES, COLON-SPECIFIC DELIVERY, SODIUM ALGINATE, ORAL DELIVERY, PHOTODYNAMIC THERAPY, TRANSDERMAL DELIVERY, CONTROLLED-RELEASE, SUSTAINED-RELEASE, IN-SITU

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MLA
Huang, Yanqi, et al. “Hard, Soft, and Hard-and-Soft Drug Delivery Carriers Based on CaCO3 and Alginate Biomaterials : Synthesis, Properties, Pharmaceutical Applications.” PHARMACEUTICS, vol. 14, no. 5, 2022, doi:10.3390/pharmaceutics14050909.
APA
Huang, Y., Cao, L., Parakhonskiy, B., & Skirtach, A. (2022). Hard, soft, and hard-and-soft drug delivery carriers based on CaCO3 and alginate biomaterials : synthesis, properties, pharmaceutical applications. PHARMACEUTICS, 14(5). https://doi.org/10.3390/pharmaceutics14050909
Chicago author-date
Huang, Yanqi, Lin Cao, Bogdan Parakhonskiy, and Andre Skirtach. 2022. “Hard, Soft, and Hard-and-Soft Drug Delivery Carriers Based on CaCO3 and Alginate Biomaterials : Synthesis, Properties, Pharmaceutical Applications.” PHARMACEUTICS 14 (5). https://doi.org/10.3390/pharmaceutics14050909.
Chicago author-date (all authors)
Huang, Yanqi, Lin Cao, Bogdan Parakhonskiy, and Andre Skirtach. 2022. “Hard, Soft, and Hard-and-Soft Drug Delivery Carriers Based on CaCO3 and Alginate Biomaterials : Synthesis, Properties, Pharmaceutical Applications.” PHARMACEUTICS 14 (5). doi:10.3390/pharmaceutics14050909.
Vancouver
1.
Huang Y, Cao L, Parakhonskiy B, Skirtach A. Hard, soft, and hard-and-soft drug delivery carriers based on CaCO3 and alginate biomaterials : synthesis, properties, pharmaceutical applications. PHARMACEUTICS. 2022;14(5).
IEEE
[1]
Y. Huang, L. Cao, B. Parakhonskiy, and A. Skirtach, “Hard, soft, and hard-and-soft drug delivery carriers based on CaCO3 and alginate biomaterials : synthesis, properties, pharmaceutical applications,” PHARMACEUTICS, vol. 14, no. 5, 2022.
@article{8750631,
  abstract     = {{Because free therapeutic drug molecules often have adverse effects on normal tissues, deliver scanty drug concentrations and exhibit a potentially low efficacy at pathological sites, various drug carriers have been developed for preclinical and clinical trials. Their physicochemical and toxicological properties are the subject of extensive research. Inorganic calcium carbonate particles are promising candidates as drug delivery carriers owning to their hardness, porous internal structure, high surface area, distinctive pH-sensitivity, low degradability, etc, while soft organic alginate hydrogels are also widely used because of their special advantages such as a high hydration, bio-adhesiveness, and non-antigenicity. Here, we review these two distinct substances as well as hybrid structures encompassing both types of carriers. Methods of their synthesis, fundamental properties and mechanisms of formation, and their respective applications are described. Furthermore, we summarize and compare similarities versus differences taking into account unique advantages and disadvantages of these drug delivery carriers. Moreover, rational combination of both carrier types due to their performance complementarity (yin-&yang properties: in general, yin is referred to for definiteness as hard, and yang is broadly taken as soft) is proposed to be used in the so-called hybrid carriers endowing them with even more advanced properties envisioned to be attractive for designing new drug delivery systems.}},
  articleno    = {{909}},
  author       = {{Huang, Yanqi and Cao, Lin and Parakhonskiy, Bogdan and Skirtach, Andre}},
  issn         = {{1999-4923}},
  journal      = {{PHARMACEUTICS}},
  keywords     = {{Pharmaceutical Science,calcium carbonate,alginate hydrogels,drug delivery,drug loading,release mechanism,CALCIUM-CARBONATE MICROPARTICLES,CORE-SHELL NANOPARTICLES,COLON-SPECIFIC DELIVERY,SODIUM ALGINATE,ORAL DELIVERY,PHOTODYNAMIC THERAPY,TRANSDERMAL DELIVERY,CONTROLLED-RELEASE,SUSTAINED-RELEASE,IN-SITU}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{44}},
  title        = {{Hard, soft, and hard-and-soft drug delivery carriers based on CaCO3 and alginate biomaterials : synthesis, properties, pharmaceutical applications}},
  url          = {{http://doi.org/10.3390/pharmaceutics14050909}},
  volume       = {{14}},
  year         = {{2022}},
}
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