Unraveling of functional activity of primary hippocampal neuron-glial networks in photodynamic therapy based on tetracyanotetra(aryl)porphyrazines
- Author
- Maria O. Savyuk, Victoria D. Turubanova, Tatiana A. Mishchenko, Svetlana A. Lermontova, Larisa G. Klapshina, Dmitri Krysko (UGent) and Maria V. Vedunova
- Organization
- Abstract
- The current efforts in photodynamic therapy (PDT) of brain cancer are focused on the development of novel photosensitizers with improved photodynamic properties, targeted specific localization, and sensitivity to the irradiation dose, ensuring the effectiveness of PDT with fewer side effects for normal nerve tissue. Here, we characterize the effects of four photosensitizers of the tetracyanotetra(aryl)porphyrazine group (pz I-IV) on the functional activity of neuron-glial networks in primary hippocampal cultures in their application in normal conditions and under PDT. The data revealed that the application of pz I-IV leads to a significant decrease in the main parameters of the functional calcium activity of neuron-glial networks and pronounced changes in the network characteristics. The observed negative effects of pz I-IV were aggravated under PDT. Considering the significant restructuring of the functional architectonics of neuron-glial networks that can lead to severe impairments in synaptic transmission and loss of brain functions, and the feasibility of direct application of PDT based on pz I-IV in the therapy of brain tumors is highly controversial. Nevertheless, the unique properties of pz I-IV retain a great prospect of their use in the therapy of tumors of another origin and cellular metabolism.
- Keywords
- VISCOSITY, CANCER, CELL, IMMUNOTHERAPY, SUBSTITUENTS, MACROCYCLES, GLIOMA, photodynamic therapy, porphyrazines, brain cancer, primary neuronal, cultures, functional neural network activity, calcium activity
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8750627
- MLA
- Savyuk, Maria O., et al. “Unraveling of Functional Activity of Primary Hippocampal Neuron-Glial Networks in Photodynamic Therapy Based on Tetracyanotetra(Aryl)Porphyrazines.” CELLS, vol. 11, no. 7, 2022, doi:10.3390/cells11071212.
- APA
- Savyuk, M. O., Turubanova, V. D., Mishchenko, T. A., Lermontova, S. A., Klapshina, L. G., Krysko, D., & Vedunova, M. V. (2022). Unraveling of functional activity of primary hippocampal neuron-glial networks in photodynamic therapy based on tetracyanotetra(aryl)porphyrazines. CELLS, 11(7). https://doi.org/10.3390/cells11071212
- Chicago author-date
- Savyuk, Maria O., Victoria D. Turubanova, Tatiana A. Mishchenko, Svetlana A. Lermontova, Larisa G. Klapshina, Dmitri Krysko, and Maria V. Vedunova. 2022. “Unraveling of Functional Activity of Primary Hippocampal Neuron-Glial Networks in Photodynamic Therapy Based on Tetracyanotetra(Aryl)Porphyrazines.” CELLS 11 (7). https://doi.org/10.3390/cells11071212.
- Chicago author-date (all authors)
- Savyuk, Maria O., Victoria D. Turubanova, Tatiana A. Mishchenko, Svetlana A. Lermontova, Larisa G. Klapshina, Dmitri Krysko, and Maria V. Vedunova. 2022. “Unraveling of Functional Activity of Primary Hippocampal Neuron-Glial Networks in Photodynamic Therapy Based on Tetracyanotetra(Aryl)Porphyrazines.” CELLS 11 (7). doi:10.3390/cells11071212.
- Vancouver
- 1.Savyuk MO, Turubanova VD, Mishchenko TA, Lermontova SA, Klapshina LG, Krysko D, et al. Unraveling of functional activity of primary hippocampal neuron-glial networks in photodynamic therapy based on tetracyanotetra(aryl)porphyrazines. CELLS. 2022;11(7).
- IEEE
- [1]M. O. Savyuk et al., “Unraveling of functional activity of primary hippocampal neuron-glial networks in photodynamic therapy based on tetracyanotetra(aryl)porphyrazines,” CELLS, vol. 11, no. 7, 2022.
@article{8750627,
abstract = {{The current efforts in photodynamic therapy (PDT) of brain cancer are focused on the development of novel photosensitizers with improved photodynamic properties, targeted specific localization, and sensitivity to the irradiation dose, ensuring the effectiveness of PDT with fewer side effects for normal nerve tissue. Here, we characterize the effects of four photosensitizers of the tetracyanotetra(aryl)porphyrazine group (pz I-IV) on the functional activity of neuron-glial networks in primary hippocampal cultures in their application in normal conditions and under PDT. The data revealed that the application of pz I-IV leads to a significant decrease in the main parameters of the functional calcium activity of neuron-glial networks and pronounced changes in the network characteristics. The observed negative effects of pz I-IV were aggravated under PDT. Considering the significant restructuring of the functional architectonics of neuron-glial networks that can lead to severe impairments in synaptic transmission and loss of brain functions, and the feasibility of direct application of PDT based on pz I-IV in the therapy of brain tumors is highly controversial. Nevertheless, the unique properties of pz I-IV retain a great prospect of their use in the therapy of tumors of another origin and cellular metabolism.}},
articleno = {{1212}},
author = {{Savyuk, Maria O. and Turubanova, Victoria D. and Mishchenko, Tatiana A. and Lermontova, Svetlana A. and Klapshina, Larisa G. and Krysko, Dmitri and Vedunova, Maria V.}},
issn = {{2073-4409}},
journal = {{CELLS}},
keywords = {{VISCOSITY,CANCER,CELL,IMMUNOTHERAPY,SUBSTITUENTS,MACROCYCLES,GLIOMA,photodynamic therapy,porphyrazines,brain cancer,primary neuronal,cultures,functional neural network activity,calcium activity}},
language = {{eng}},
number = {{7}},
pages = {{15}},
title = {{Unraveling of functional activity of primary hippocampal neuron-glial networks in photodynamic therapy based on tetracyanotetra(aryl)porphyrazines}},
url = {{http://doi.org/10.3390/cells11071212}},
volume = {{11}},
year = {{2022}},
}
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