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Deciphering the non-coding RNA landscape of pediatric acute myeloid leukemia

(2022) CANCERS. 14(9).
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Abstract
Pediatric acute myeloid leukemia (pedAML) is a heterogeneous blood cancer that affects children. Although survival rates have significantly improved over the past few decades, 20–30% of children will succumb due to treatment-related toxicity or relapse. The molecular characterization of the leukemic stem cell, shown to be responsible for relapse, is needed to improve treatment options and survival. Recently, it has become clear that non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play a role in the development of human diseases, including pediatric cancer. Nevertheless, non-coding RNA expression data in pedAML are scarce. Here, we explored lncRNA (n = 30168) and miRNA (n = 627) expression in pedAML subpopulations (leukemic stem cells (LSCs) and leukemic blasts (L-blasts)) and their normal counterparts (hematopoietic stem cells and control myeloblasts). The potential regulatory activity of differentially expressed lncRNAs in LSCs (unique or shared with the L-blast comparison) on miRNAs was assessed. Moreover, pre-ranked gene set enrichment analyses of (anti-) correlated protein-coding genes were performed to predict the functional relevance of the differentially upregulated lncRNAs in LSCs (unique or shared with the L-blast comparison). In conclusion, this study provides a catalog of non-coding RNAs with a potential role in the pathogenesis of pedAML, paving the way for further translational research studies.
Keywords
Cancer Research, Oncology, pediatric AML, non-coding RNA, cellular subpopulations, STEM-CELLS, PROGRESSION, EXPRESSION, CANCER, PROLIFERATION, SUPPRESSES, APOPTOSIS, GENE

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MLA
Vanhooren, Jolien, et al. “Deciphering the Non-Coding RNA Landscape of Pediatric Acute Myeloid Leukemia.” CANCERS, vol. 14, no. 9, 2022, doi:10.3390/cancers14092098.
APA
Vanhooren, J., Van Camp, L., Depreter, B., de Jong, M., Uyttebroeck, A., Van Damme, A. V., … Lammens, T. (2022). Deciphering the non-coding RNA landscape of pediatric acute myeloid leukemia. CANCERS, 14(9). https://doi.org/10.3390/cancers14092098
Chicago author-date
Vanhooren, Jolien, Laurens Van Camp, Barbara Depreter, Martijn de Jong, Anne Uyttebroeck, An Van Van Damme, Laurence Dedeken, et al. 2022. “Deciphering the Non-Coding RNA Landscape of Pediatric Acute Myeloid Leukemia.” CANCERS 14 (9). https://doi.org/10.3390/cancers14092098.
Chicago author-date (all authors)
Vanhooren, Jolien, Laurens Van Camp, Barbara Depreter, Martijn de Jong, Anne Uyttebroeck, An Van Van Damme, Laurence Dedeken, Marie-Françoise Dresse, Jutte van der Werff ten Bosch, Mattias Hofmans, Jan Philippé, Barbara De Moerloose, and Tim Lammens. 2022. “Deciphering the Non-Coding RNA Landscape of Pediatric Acute Myeloid Leukemia.” CANCERS 14 (9). doi:10.3390/cancers14092098.
Vancouver
1.
Vanhooren J, Van Camp L, Depreter B, de Jong M, Uyttebroeck A, Van Damme AV, et al. Deciphering the non-coding RNA landscape of pediatric acute myeloid leukemia. CANCERS. 2022;14(9).
IEEE
[1]
J. Vanhooren et al., “Deciphering the non-coding RNA landscape of pediatric acute myeloid leukemia,” CANCERS, vol. 14, no. 9, 2022.
@article{8750554,
  abstract     = {{Pediatric acute myeloid leukemia (pedAML) is a heterogeneous blood cancer that affects children. Although survival rates have significantly improved over the past few decades, 20–30% of children will succumb due to treatment-related toxicity or relapse. The molecular characterization of the leukemic stem cell, shown to be responsible for relapse, is needed to improve treatment options and survival. Recently, it has become clear that non-coding RNAs, including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play a role in the development of human diseases, including pediatric cancer. Nevertheless, non-coding RNA expression data in pedAML are scarce. Here, we explored lncRNA (n = 30168) and miRNA (n = 627) expression in pedAML subpopulations (leukemic stem cells (LSCs) and leukemic blasts (L-blasts)) and their normal counterparts (hematopoietic stem cells and control myeloblasts). The potential regulatory activity of differentially expressed lncRNAs in LSCs (unique or shared with the L-blast comparison) on miRNAs was assessed. Moreover, pre-ranked gene set enrichment analyses of (anti-) correlated protein-coding genes were performed to predict the functional relevance of the differentially upregulated lncRNAs in LSCs (unique or shared with the L-blast comparison). In conclusion, this study provides a catalog of non-coding RNAs with a potential role in the pathogenesis of pedAML, paving the way for further translational research studies.}},
  articleno    = {{2098}},
  author       = {{Vanhooren, Jolien and Van Camp, Laurens and Depreter, Barbara and de Jong, Martijn and Uyttebroeck, Anne and Van Damme, An Van and Dedeken, Laurence and Dresse, Marie-Françoise and van der Werff ten Bosch, Jutte and Hofmans, Mattias and Philippé, Jan and De Moerloose, Barbara and Lammens, Tim}},
  issn         = {{2072-6694}},
  journal      = {{CANCERS}},
  keywords     = {{Cancer Research,Oncology,pediatric AML,non-coding RNA,cellular subpopulations,STEM-CELLS,PROGRESSION,EXPRESSION,CANCER,PROLIFERATION,SUPPRESSES,APOPTOSIS,GENE}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{15}},
  title        = {{Deciphering the non-coding RNA landscape of pediatric acute myeloid leukemia}},
  url          = {{http://doi.org/10.3390/cancers14092098}},
  volume       = {{14}},
  year         = {{2022}},
}

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