Advanced search
1 file | 2.10 MB Add to list

In vitro microbial metabolism of (+)-catechin reveals fast and slow converters with individual-specific microbial and metabolite markers

Author
Organization
Abstract
ABSTRACT: The bioavailability of catechin highly relies on gut microbiota which may determine its metabolic profile, resulting in different health outcomes. Here, we investigated in vitro (+)-catechin metabolism by human microbial communities. There were substantial interindividual differences in the metabolic profiles of (+)-catechin, with 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone being the major contributor. Furthermore, the microbial metabolic rate of catechin enabled stratification of 12 participants (fast, medium, and slow converters), despite the interference from the strong intrinsic interindividual variability in fecal microbiota. Correlations were established between this stratified population and microbiota features, such as ecosystem diversity. Additionally, fast converters had significantly higher prevalences of amplicon sequence variants (ASVs) with potential capacity of C-ring cleavage (ASV233_ Eggerthella and ASV402_Eubacterium), B-ring dihydroxylation (ASV402_Eubacterium), and short-chain fatty acid (SCFA)producing ASVs. In conclusion, metabolic-capability-based stratification allows us to uncover differences in microbial composition between fast and slow converters, which could help to elucidate interindividual variabilities in the health benefits of catechins.
Keywords
catechins, microbial metabolism, metabolites, microbiota, interindividual variability, phenyl, phenyl-&gamma, -valerolactones, (-)-EPICATECHIN, DEHYDROXYLATION, BIOAVAILABILITY, COLONIZATION, POLYPHENOLS, CATECHINS, BUTYRATE, RING

Downloads

  • (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 2.10 MB

Citation

Please use this url to cite or link to this publication:

MLA
Li, Qiqiong, et al. “In Vitro Microbial Metabolism of (+)-Catechin Reveals Fast and Slow Converters with Individual-Specific Microbial and Metabolite Markers.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 70, no. 34, 2022, pp. 10405–16, doi:10.1021/acs.jafc.2c00551.
APA
Li, Q., Van Herreweghen, F., Onyango, S. O., De Mey, M., & Van de Wiele, T. (2022). In vitro microbial metabolism of (+)-catechin reveals fast and slow converters with individual-specific microbial and metabolite markers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 70(34), 10405–10416. https://doi.org/10.1021/acs.jafc.2c00551
Chicago author-date
Li, Qiqiong, Florence Van Herreweghen, Stanley Omondi Onyango, Marjan De Mey, and Tom Van de Wiele. 2022. “In Vitro Microbial Metabolism of (+)-Catechin Reveals Fast and Slow Converters with Individual-Specific Microbial and Metabolite Markers.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70 (34): 10405–16. https://doi.org/10.1021/acs.jafc.2c00551.
Chicago author-date (all authors)
Li, Qiqiong, Florence Van Herreweghen, Stanley Omondi Onyango, Marjan De Mey, and Tom Van de Wiele. 2022. “In Vitro Microbial Metabolism of (+)-Catechin Reveals Fast and Slow Converters with Individual-Specific Microbial and Metabolite Markers.” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70 (34): 10405–10416. doi:10.1021/acs.jafc.2c00551.
Vancouver
1.
Li Q, Van Herreweghen F, Onyango SO, De Mey M, Van de Wiele T. In vitro microbial metabolism of (+)-catechin reveals fast and slow converters with individual-specific microbial and metabolite markers. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2022;70(34):10405–16.
IEEE
[1]
Q. Li, F. Van Herreweghen, S. O. Onyango, M. De Mey, and T. Van de Wiele, “In vitro microbial metabolism of (+)-catechin reveals fast and slow converters with individual-specific microbial and metabolite markers,” JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, vol. 70, no. 34, pp. 10405–10416, 2022.
@article{8749756,
  abstract     = {{ABSTRACT: The bioavailability of catechin highly relies on gut microbiota which may determine its metabolic profile, resulting in different health outcomes. Here, we investigated in vitro (+)-catechin metabolism by human microbial communities. There were substantial interindividual differences in the metabolic profiles of (+)-catechin, with 5-(3 ',4 '-dihydroxyphenyl)-gamma-valerolactone being the major contributor. Furthermore, the microbial metabolic rate of catechin enabled stratification of 12 participants (fast, medium, and slow converters), despite the interference from the strong intrinsic interindividual variability in fecal microbiota. Correlations were established between this stratified population and microbiota features, such as ecosystem diversity. Additionally, fast converters had significantly higher prevalences of amplicon sequence variants (ASVs) with potential capacity of C-ring cleavage (ASV233_ Eggerthella and ASV402_Eubacterium), B-ring dihydroxylation (ASV402_Eubacterium), and short-chain fatty acid (SCFA)producing ASVs. In conclusion, metabolic-capability-based stratification allows us to uncover differences in microbial composition between fast and slow converters, which could help to elucidate interindividual variabilities in the health benefits of catechins.}},
  author       = {{Li, Qiqiong and Van Herreweghen, Florence and Onyango, Stanley Omondi and De Mey, Marjan and Van de Wiele, Tom}},
  issn         = {{0021-8561}},
  journal      = {{JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY}},
  keywords     = {{catechins,microbial metabolism,metabolites,microbiota,interindividual variability,phenyl,phenyl-&gamma,-valerolactones,(-)-EPICATECHIN,DEHYDROXYLATION,BIOAVAILABILITY,COLONIZATION,POLYPHENOLS,CATECHINS,BUTYRATE,RING}},
  language     = {{eng}},
  number       = {{34}},
  pages        = {{10405--10416}},
  title        = {{In vitro microbial metabolism of (+)-catechin reveals fast and slow converters with individual-specific microbial and metabolite markers}},
  url          = {{http://doi.org/10.1021/acs.jafc.2c00551}},
  volume       = {{70}},
  year         = {{2022}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: