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Sepsis : a failing starvation response

Jolien Vandewalle (UGent) and Claude Libert (UGent)
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Abstract
Sepsis is involved in similar to 20% of annual global deaths. Despite decades of research, the current management of sepsis remains supportive rather than curative. Clinical trials in sepsis have mainly been focused on targeting the inflammatory pathway, but without success. Recent data indicate that metabolic dysregulation takes place in sepsis, and targeting metabolic pathways might hold much promise for the management of sepsis. Sepsis yields a strong starvation response, including the release of high-energy metabolites such as lactate and free fatty acids. However, the activity of two major transcription factors, GR and PPAR alpha, is downregulated in hepatocytes, leading to the accumulation and toxicity of metabolites that, moreover, fail to be transformed into useful molecules such as glucose and ketones. We review the literature and suggest mechanisms and potential therapeutic targets that might prevent or revert the fatal metabolic dysregulation in sepsis.

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Citation

Please use this url to cite or link to this publication:

MLA
Vandewalle, Jolien, and Claude Libert. “Sepsis : A Failing Starvation Response.” TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 33, no. 4, 2022, pp. 292–304, doi:10.1016/j.tem.2022.01.006.
APA
Vandewalle, J., & Libert, C. (2022). Sepsis : a failing starvation response. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 33(4), 292–304. https://doi.org/10.1016/j.tem.2022.01.006
Chicago author-date
Vandewalle, Jolien, and Claude Libert. 2022. “Sepsis : A Failing Starvation Response.” TRENDS IN ENDOCRINOLOGY AND METABOLISM 33 (4): 292–304. https://doi.org/10.1016/j.tem.2022.01.006.
Chicago author-date (all authors)
Vandewalle, Jolien, and Claude Libert. 2022. “Sepsis : A Failing Starvation Response.” TRENDS IN ENDOCRINOLOGY AND METABOLISM 33 (4): 292–304. doi:10.1016/j.tem.2022.01.006.
Vancouver
1.
Vandewalle J, Libert C. Sepsis : a failing starvation response. TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2022;33(4):292–304.
IEEE
[1]
J. Vandewalle and C. Libert, “Sepsis : a failing starvation response,” TRENDS IN ENDOCRINOLOGY AND METABOLISM, vol. 33, no. 4, pp. 292–304, 2022.
@article{8748824,
  abstract     = {{Sepsis is involved in similar to 20% of annual global deaths. Despite decades of research, the current management of sepsis remains supportive rather than curative. Clinical trials in sepsis have mainly been focused on targeting the inflammatory pathway, but without success. Recent data indicate that metabolic dysregulation takes place in sepsis, and targeting metabolic pathways might hold much promise for the management of sepsis. Sepsis yields a strong starvation response, including the release of high-energy metabolites such as lactate and free fatty acids. However, the activity of two major transcription factors, GR and PPAR alpha, is downregulated in hepatocytes, leading to the accumulation and toxicity of metabolites that, moreover, fail to be transformed into useful molecules such as glucose and ketones. We review the literature and suggest mechanisms and potential therapeutic targets that might prevent or revert the fatal metabolic dysregulation in sepsis.}},
  author       = {{Vandewalle, Jolien and Libert, Claude}},
  issn         = {{1043-2760}},
  journal      = {{TRENDS IN ENDOCRINOLOGY AND METABOLISM}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{292--304}},
  title        = {{Sepsis : a failing starvation response}},
  url          = {{http://doi.org/10.1016/j.tem.2022.01.006}},
  volume       = {{33}},
  year         = {{2022}},
}

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