Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer
- Author
- Steven Timmermans (UGent) , Jolien Vandewalle (UGent) and Claude Libert (UGent)
- Organization
- Project
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- Elucidating the details of the interaction between specific nutrients-microbiota-intestinal health and the consequences for inflammatory diseases
- STOP SEPSIS
- Developing a broadly protecting vaccine against polymicrobial sepsis.
- Investigation of the mechanism of the loss of function of HNF4a-PPARa axis in polymicrobial sepsis.
- Promoting intestinal health by modulating the Zinc-microbiome axis at the Paneth cell level (acronym: ZIPAM)
- STOP_SEPSIS: investigation into a new concept of sepsis, the greatest unmet medical need of our times.
- Abstract
- The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms, interacts with many proteins and has multiple functions. Numerous therapies are based on GRs' actions but the occurrence of side effects and reduced responses to glucocorticoids have motivated scientists to study GRs in great detail. The notion that GRs can perform functions as a monomeric protein, but also as a homodimer has raised questions about the underlying mechanisms, structural aspects of dimerization, influencing factors and biological functions. In this review paper, we are providing an overview of the current knowledge and insights about this important aspect of GR biology.
- Keywords
- glucocorticoids, glucocorticoid receptor, dimerization, sepsis, mutants, LIGAND-BINDING DOMAIN, RAY CRYSTAL-STRUCTURE, TUMOR-NECROSIS-FACTOR, DNA-BINDING, RESPONSE ELEMENTS, BETA-ISOFORM, SEPTIC SHOCK, HORMONE, DIMER, ACTIVATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8748264
- MLA
- Timmermans, Steven, et al. “Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)Physiology : A Primer.” CELLS, vol. 11, no. 4, 2022, doi:10.3390/cells11040683.
- APA
- Timmermans, S., Vandewalle, J., & Libert, C. (2022). Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer. CELLS, 11(4). https://doi.org/10.3390/cells11040683
- Chicago author-date
- Timmermans, Steven, Jolien Vandewalle, and Claude Libert. 2022. “Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)Physiology : A Primer.” CELLS 11 (4). https://doi.org/10.3390/cells11040683.
- Chicago author-date (all authors)
- Timmermans, Steven, Jolien Vandewalle, and Claude Libert. 2022. “Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)Physiology : A Primer.” CELLS 11 (4). doi:10.3390/cells11040683.
- Vancouver
- 1.Timmermans S, Vandewalle J, Libert C. Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer. CELLS. 2022;11(4).
- IEEE
- [1]S. Timmermans, J. Vandewalle, and C. Libert, “Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer,” CELLS, vol. 11, no. 4, 2022.
@article{8748264,
abstract = {{The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms, interacts with many proteins and has multiple functions. Numerous therapies are based on GRs' actions but the occurrence of side effects and reduced responses to glucocorticoids have motivated scientists to study GRs in great detail. The notion that GRs can perform functions as a monomeric protein, but also as a homodimer has raised questions about the underlying mechanisms, structural aspects of dimerization, influencing factors and biological functions. In this review paper, we are providing an overview of the current knowledge and insights about this important aspect of GR biology.}},
articleno = {{683}},
author = {{Timmermans, Steven and Vandewalle, Jolien and Libert, Claude}},
issn = {{2073-4409}},
journal = {{CELLS}},
keywords = {{glucocorticoids,glucocorticoid receptor,dimerization,sepsis,mutants,LIGAND-BINDING DOMAIN,RAY CRYSTAL-STRUCTURE,TUMOR-NECROSIS-FACTOR,DNA-BINDING,RESPONSE ELEMENTS,BETA-ISOFORM,SEPTIC SHOCK,HORMONE,DIMER,ACTIVATION}},
language = {{eng}},
number = {{4}},
pages = {{22}},
title = {{Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer}},
url = {{http://doi.org/10.3390/cells11040683}},
volume = {{11}},
year = {{2022}},
}
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