Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer
- Author
- Steven Timmermans (UGent) , Jolien Vandewalle (UGent) and Claude Libert (UGent)
- Organization
- Abstract
- The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms, interacts with many proteins and has multiple functions. Numerous therapies are based on GRs' actions but the occurrence of side effects and reduced responses to glucocorticoids have motivated scientists to study GRs in great detail. The notion that GRs can perform functions as a monomeric protein, but also as a homodimer has raised questions about the underlying mechanisms, structural aspects of dimerization, influencing factors and biological functions. In this review paper, we are providing an overview of the current knowledge and insights about this important aspect of GR biology.
- Keywords
- glucocorticoids, glucocorticoid receptor, dimerization, sepsis, mutants, LIGAND-BINDING DOMAIN, RAY CRYSTAL-STRUCTURE, TUMOR-NECROSIS-FACTOR, DNA-BINDING, RESPONSE ELEMENTS, BETA-ISOFORM, SEPTIC SHOCK, HORMONE, DIMER, ACTIVATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8748264
- MLA
- Timmermans, Steven, et al. “Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)Physiology : A Primer.” CELLS, vol. 11, no. 4, 2022, doi:10.3390/cells11040683.
- APA
- Timmermans, S., Vandewalle, J., & Libert, C. (2022). Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer. CELLS, 11(4). https://doi.org/10.3390/cells11040683
- Chicago author-date
- Timmermans, Steven, Jolien Vandewalle, and Claude Libert. 2022. “Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)Physiology : A Primer.” CELLS 11 (4). https://doi.org/10.3390/cells11040683.
- Chicago author-date (all authors)
- Timmermans, Steven, Jolien Vandewalle, and Claude Libert. 2022. “Dimerization of the Glucocorticoid Receptor and Its Importance in (Patho)Physiology : A Primer.” CELLS 11 (4). doi:10.3390/cells11040683.
- Vancouver
- 1.Timmermans S, Vandewalle J, Libert C. Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer. CELLS. 2022;11(4).
- IEEE
- [1]S. Timmermans, J. Vandewalle, and C. Libert, “Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer,” CELLS, vol. 11, no. 4, 2022.
@article{8748264,
abstract = {{The glucocorticoid receptor (GR) is a very versatile protein that comes in several forms, interacts with many proteins and has multiple functions. Numerous therapies are based on GRs' actions but the occurrence of side effects and reduced responses to glucocorticoids have motivated scientists to study GRs in great detail. The notion that GRs can perform functions as a monomeric protein, but also as a homodimer has raised questions about the underlying mechanisms, structural aspects of dimerization, influencing factors and biological functions. In this review paper, we are providing an overview of the current knowledge and insights about this important aspect of GR biology.}},
articleno = {{683}},
author = {{Timmermans, Steven and Vandewalle, Jolien and Libert, Claude}},
issn = {{2073-4409}},
journal = {{CELLS}},
keywords = {{glucocorticoids,glucocorticoid receptor,dimerization,sepsis,mutants,LIGAND-BINDING DOMAIN,RAY CRYSTAL-STRUCTURE,TUMOR-NECROSIS-FACTOR,DNA-BINDING,RESPONSE ELEMENTS,BETA-ISOFORM,SEPTIC SHOCK,HORMONE,DIMER,ACTIVATION}},
language = {{eng}},
number = {{4}},
pages = {{22}},
title = {{Dimerization of the glucocorticoid receptor and its importance in (patho)physiology : a primer}},
url = {{http://dx.doi.org/10.3390/cells11040683}},
volume = {{11}},
year = {{2022}},
}
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