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Physicians' and pharmacists' views and experiences regarding use of direct oral anticoagulants in clinical practice

Andreas Capiau (UGent) , Els Mehuys (UGent) , Eline Dhondt, Tine De Backer (UGent) and Koen Boussery (UGent)
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Organization
Abstract
Aim Direct oral anticoagulants (DOACs) are increasingly used compared to vitamin K antagonists (VKAs). Guidelines advocate a structured multidisciplinary approach in the management of patients treated with DOACs. The aim of this study was to assess the views and experiences of physicians and pharmacists regarding DOAC use in clinical practice. Methods An online questionnaire was sent to both primary (general practitioners [GPs], community pharmacists) and secondary healthcare professionals (cardiologists, residents in internal medicine and hospital pharmacists) between March and July 2020. The questionnaire covered four topics: (i) current practice, (ii) prescribing behaviour (only for physicians), (iii) self-perceived knowledge about DOACs and (iv) views and opinions about DOACs versus VKAs. Results In total, 110 physicians and 111 pharmacists completed the survey. Healthcare professionals in secondary care had more experience with DOACs and felt more confident with higher self-perceived knowledge about DOACs compared to their colleagues in primary care. Healthcare professionals' self-perceived knowledge was more or less complementary, for example physicians felt less confident in managing drug-drug interactions (DDIs) where pharmacists reported being more confident in this topic. Physicians reported uncertainties on the potential impact of risk factors - such as older age, lower body weight and DDIs - on appropriate DOAC dosing. Conclusion Complementarity in physicians' and pharmacists' self-perceived knowledge levels of DOACs may facilitate and necessitate future multidisciplinary collaboration initiatives for the management and follow-up of DOAC patients.
Keywords
ATRIAL-FIBRILLATION, ANTITHROMBOTIC THERAPY, CHEST GUIDELINE, WARFARIN, ADHERENCE, CARE, drug information, drug utilization, prescribing, quality use of, medicines

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MLA
Capiau, Andreas, et al. “Physicians’ and Pharmacists’ Views and Experiences Regarding Use of Direct Oral Anticoagulants in Clinical Practice.” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 88, no. 4, 2022, pp. 1856–65, doi:10.1111/bcp.15106.
APA
Capiau, A., Mehuys, E., Dhondt, E., De Backer, T., & Boussery, K. (2022). Physicians’ and pharmacists’ views and experiences regarding use of direct oral anticoagulants in clinical practice. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 88(4), 1856–1865. https://doi.org/10.1111/bcp.15106
Chicago author-date
Capiau, Andreas, Els Mehuys, Eline Dhondt, Tine De Backer, and Koen Boussery. 2022. “Physicians’ and Pharmacists’ Views and Experiences Regarding Use of Direct Oral Anticoagulants in Clinical Practice.” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 88 (4): 1856–65. https://doi.org/10.1111/bcp.15106.
Chicago author-date (all authors)
Capiau, Andreas, Els Mehuys, Eline Dhondt, Tine De Backer, and Koen Boussery. 2022. “Physicians’ and Pharmacists’ Views and Experiences Regarding Use of Direct Oral Anticoagulants in Clinical Practice.” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 88 (4): 1856–1865. doi:10.1111/bcp.15106.
Vancouver
1.
Capiau A, Mehuys E, Dhondt E, De Backer T, Boussery K. Physicians’ and pharmacists’ views and experiences regarding use of direct oral anticoagulants in clinical practice. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2022;88(4):1856–65.
IEEE
[1]
A. Capiau, E. Mehuys, E. Dhondt, T. De Backer, and K. Boussery, “Physicians’ and pharmacists’ views and experiences regarding use of direct oral anticoagulants in clinical practice,” BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, vol. 88, no. 4, pp. 1856–1865, 2022.
@article{8748188,
  abstract     = {{Aim Direct oral anticoagulants (DOACs) are increasingly used compared to vitamin K antagonists (VKAs). Guidelines advocate a structured multidisciplinary approach in the management of patients treated with DOACs. The aim of this study was to assess the views and experiences of physicians and pharmacists regarding DOAC use in clinical practice. Methods An online questionnaire was sent to both primary (general practitioners [GPs], community pharmacists) and secondary healthcare professionals (cardiologists, residents in internal medicine and hospital pharmacists) between March and July 2020. The questionnaire covered four topics: (i) current practice, (ii) prescribing behaviour (only for physicians), (iii) self-perceived knowledge about DOACs and (iv) views and opinions about DOACs versus VKAs. Results In total, 110 physicians and 111 pharmacists completed the survey. Healthcare professionals in secondary care had more experience with DOACs and felt more confident with higher self-perceived knowledge about DOACs compared to their colleagues in primary care. Healthcare professionals' self-perceived knowledge was more or less complementary, for example physicians felt less confident in managing drug-drug interactions (DDIs) where pharmacists reported being more confident in this topic. Physicians reported uncertainties on the potential impact of risk factors - such as older age, lower body weight and DDIs - on appropriate DOAC dosing. Conclusion Complementarity in physicians' and pharmacists' self-perceived knowledge levels of DOACs may facilitate and necessitate future multidisciplinary collaboration initiatives for the management and follow-up of DOAC patients.}},
  author       = {{Capiau, Andreas and Mehuys, Els and Dhondt, Eline and De Backer, Tine and Boussery, Koen}},
  issn         = {{0306-5251}},
  journal      = {{BRITISH JOURNAL OF CLINICAL PHARMACOLOGY}},
  keywords     = {{ATRIAL-FIBRILLATION,ANTITHROMBOTIC THERAPY,CHEST GUIDELINE,WARFARIN,ADHERENCE,CARE,drug information,drug utilization,prescribing,quality use of,medicines}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1856--1865}},
  title        = {{Physicians' and pharmacists' views and experiences regarding use of direct oral anticoagulants in clinical practice}},
  url          = {{http://doi.org/10.1111/bcp.15106}},
  volume       = {{88}},
  year         = {{2022}},
}

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