Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering
- Author
- Quinten Thijssen (UGent) , Kim Cornelis, Rand Alkaissy, Janis Locs, Lana Van Damme (UGent) , David Schaubroeck (UGent) , Robin Willaert, Sarah Snelling, Pierre-Alexis Mouthuy and Sandra Van Vlierberghe (UGent)
- Organization
- Project
- Abstract
- Acrylate-based photo-cross-linked poly(s-caprolactone) (PCL) tends to show low elongation and strength. Incorporation of osteo-inductive hydroxyapatite (HAp) further enhances this effect, which limits its applicability in bone tissue engineering. To overcome this, the thiol-ene click reaction is introduced for the first time in order to photo-cross-link PCL composites with 0, 10, 20, and 30 wt % HAp nanoparticles. It is demonstrated that the elongation at break and ultimate stren increase 10-and 2-fold, respectively, when the photopolymerization mechanism is shifted from a radical chain-growth (i.e., acrylate cross-linking) toward a radical step-growth polymerization (i.e., thiol-ene cross-linking). Additionally, it is illustrated that osteoblasts can attach to and proliferate on the surface of the photo-cross-linked PCL-HAp composites. Finally, the incorporation of HAp nanopartides is shown to reduce the ALP activity of osteoblasts. Overall, thiol-ene cross-linked PCL-HAp composites can be considered as promising potential materials for bone tissue engineering.
- Keywords
- Materials Chemistry, Polymers and Plastics, Biomaterials, Bioengineering, OSTEOBLAST-LIKE CELLS, SCAFFOLDS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8747784
- MLA
- Thijssen, Quinten, et al. “Tough Photo-Cross-Linked PCL-Hydroxyapatite Composites for Bone Tissue Engineering.” BIOMACROMOLECULES, vol. 23, no. 3, 2022, pp. 1366–75, doi:10.1021/acs.biomac.1c01584.
- APA
- Thijssen, Q., Cornelis, K., Alkaissy, R., Locs, J., Van Damme, L., Schaubroeck, D., … Van Vlierberghe, S. (2022). Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering. BIOMACROMOLECULES, 23(3), 1366–1375. https://doi.org/10.1021/acs.biomac.1c01584
- Chicago author-date
- Thijssen, Quinten, Kim Cornelis, Rand Alkaissy, Janis Locs, Lana Van Damme, David Schaubroeck, Robin Willaert, Sarah Snelling, Pierre-Alexis Mouthuy, and Sandra Van Vlierberghe. 2022. “Tough Photo-Cross-Linked PCL-Hydroxyapatite Composites for Bone Tissue Engineering.” BIOMACROMOLECULES 23 (3): 1366–75. https://doi.org/10.1021/acs.biomac.1c01584.
- Chicago author-date (all authors)
- Thijssen, Quinten, Kim Cornelis, Rand Alkaissy, Janis Locs, Lana Van Damme, David Schaubroeck, Robin Willaert, Sarah Snelling, Pierre-Alexis Mouthuy, and Sandra Van Vlierberghe. 2022. “Tough Photo-Cross-Linked PCL-Hydroxyapatite Composites for Bone Tissue Engineering.” BIOMACROMOLECULES 23 (3): 1366–1375. doi:10.1021/acs.biomac.1c01584.
- Vancouver
- 1.Thijssen Q, Cornelis K, Alkaissy R, Locs J, Van Damme L, Schaubroeck D, et al. Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering. BIOMACROMOLECULES. 2022;23(3):1366–75.
- IEEE
- [1]Q. Thijssen et al., “Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering,” BIOMACROMOLECULES, vol. 23, no. 3, pp. 1366–1375, 2022.
@article{8747784,
abstract = {{Acrylate-based photo-cross-linked poly(s-caprolactone) (PCL) tends to show low elongation and strength. Incorporation of osteo-inductive hydroxyapatite (HAp) further enhances this effect, which limits its applicability in bone tissue engineering. To overcome this, the thiol-ene click reaction is introduced for the first time in order to photo-cross-link PCL composites with 0, 10, 20, and 30 wt % HAp nanoparticles. It is demonstrated that the elongation at break and ultimate stren increase 10-and 2-fold, respectively, when the photopolymerization mechanism is shifted from a radical chain-growth (i.e., acrylate cross-linking) toward a radical step-growth polymerization (i.e., thiol-ene cross-linking). Additionally, it is illustrated that osteoblasts can attach to and proliferate on the surface of the photo-cross-linked PCL-HAp composites. Finally, the incorporation of HAp nanopartides is shown to reduce the ALP activity of osteoblasts. Overall, thiol-ene cross-linked PCL-HAp composites can be considered as promising potential materials for bone tissue engineering.}},
author = {{Thijssen, Quinten and Cornelis, Kim and Alkaissy, Rand and Locs, Janis and Van Damme, Lana and Schaubroeck, David and Willaert, Robin and Snelling, Sarah and Mouthuy, Pierre-Alexis and Van Vlierberghe, Sandra}},
issn = {{1525-7797}},
journal = {{BIOMACROMOLECULES}},
keywords = {{Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,OSTEOBLAST-LIKE CELLS,SCAFFOLDS}},
language = {{eng}},
number = {{3}},
pages = {{1366--1375}},
title = {{Tough photo-cross-linked PCL-hydroxyapatite composites for bone tissue engineering}},
url = {{http://doi.org/10.1021/acs.biomac.1c01584}},
volume = {{23}},
year = {{2022}},
}
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