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Biomaterials for manufacturing scaffolds : a compromise between resolution, size and biocompatibility

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Abstract
Materials play a key role in tissue engineering for the construction of 3-dimensional scaffolds that support the formation of a new extracellular matrix. They should be biocompatible, and for the fabrication of functional scaffolds, they should be mechanically robust, provide high resolution and printability factors to use in one-photon polymerization micro-stereolithography (OPP mu-SLA) technologies. Furthermore, applications where those materials are used, such as tissue regeneration or tissue substitutes, require fabrication approaches that allow the scalability of 3D scaffold for their clinical use. Therefore, both materials and technology need to be optimized and improved. We tackle two research tracks, one to provide high resolution and biocompatible materials that can be used in OPP- mu-SLA, and a second one to obtain a new mu-SLA configuration that can boost large-size scaffold fabrication for tissue engineering applications. In this work, we report our progress towards the formulation of a hydrogel based on the prototype resin X HYDRORES INX X100 from XPECT INX and we describe the configuration based on the beam shaping of a laser source to print centimeter scale scaffolds while conserving micro-scale features. We printed scaffolds with a commercial ABS resin and the bio-inert hydrogel from XPECT INX that allow us to compare resolution, printability, and mechanical stability. Our results evidence structures with voxel widths up to 20 mu m and lengths up to 23 mm by using uniform light sheets illumination patterns. This work set new alternatives for the material and the fabrication aspects of additive manufacturing for 3D biofabrication.
Keywords
biofabrication, 3D scaffolds, hydrogels, tissue engineering, wound, dressing, micro-stereolithography, one photon polymerization

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MLA
Madrid-Sanchez, Alejandro, et al. “Biomaterials for Manufacturing Scaffolds : A Compromise between Resolution, Size and Biocompatibility.” OPTICAL METHODS FOR INSPECTION, CHARACTERIZATION, AND IMAGING OF BIOMATERIALS V, edited by P. Ferraro et al., vol. 11786, SPIE, 2021, doi:10.1117/12.2593342.
APA
Madrid-Sanchez, A., Van Hoorick, J., Nie, Y., Duerr, F., Van Vlierberghe, S., Dubruel, P., … Ottevaere, H. (2021). Biomaterials for manufacturing scaffolds : a compromise between resolution, size and biocompatibility. In P. Ferraro, S. Grilli, M. RitschMarte, & C. K. Hitzenberger (Eds.), OPTICAL METHODS FOR INSPECTION, CHARACTERIZATION, AND IMAGING OF BIOMATERIALS V (Vol. 11786). https://doi.org/10.1117/12.2593342
Chicago author-date
Madrid-Sanchez, Alejandro, Jasper Van Hoorick, Yunfeng Nie, Fabian Duerr, Sandra Van Vlierberghe, Peter Dubruel, Hugo Thienpont, and Heidi Ottevaere. 2021. “Biomaterials for Manufacturing Scaffolds : A Compromise between Resolution, Size and Biocompatibility.” In OPTICAL METHODS FOR INSPECTION, CHARACTERIZATION, AND IMAGING OF BIOMATERIALS V, edited by P. Ferraro, S. Grilli, M. RitschMarte, and C. K. Hitzenberger. Vol. 11786. Bellingham: SPIE. https://doi.org/10.1117/12.2593342.
Chicago author-date (all authors)
Madrid-Sanchez, Alejandro, Jasper Van Hoorick, Yunfeng Nie, Fabian Duerr, Sandra Van Vlierberghe, Peter Dubruel, Hugo Thienpont, and Heidi Ottevaere. 2021. “Biomaterials for Manufacturing Scaffolds : A Compromise between Resolution, Size and Biocompatibility.” In OPTICAL METHODS FOR INSPECTION, CHARACTERIZATION, AND IMAGING OF BIOMATERIALS V, ed by. P. Ferraro, S. Grilli, M. RitschMarte, and C. K. Hitzenberger. Vol. 11786. Bellingham: SPIE. doi:10.1117/12.2593342.
Vancouver
1.
Madrid-Sanchez A, Van Hoorick J, Nie Y, Duerr F, Van Vlierberghe S, Dubruel P, et al. Biomaterials for manufacturing scaffolds : a compromise between resolution, size and biocompatibility. In: Ferraro P, Grilli S, RitschMarte M, Hitzenberger CK, editors. OPTICAL METHODS FOR INSPECTION, CHARACTERIZATION, AND IMAGING OF BIOMATERIALS V. Bellingham: SPIE; 2021.
IEEE
[1]
A. Madrid-Sanchez et al., “Biomaterials for manufacturing scaffolds : a compromise between resolution, size and biocompatibility,” in OPTICAL METHODS FOR INSPECTION, CHARACTERIZATION, AND IMAGING OF BIOMATERIALS V, Online, 2021, vol. 11786.
@inproceedings{8747721,
  abstract     = {{Materials play a key role in tissue engineering for the construction of 3-dimensional scaffolds that support the formation of a new extracellular matrix. They should be biocompatible, and for the fabrication of functional scaffolds, they should be mechanically robust, provide high resolution and printability factors to use in one-photon polymerization micro-stereolithography (OPP mu-SLA) technologies. Furthermore, applications where those materials are used, such as tissue regeneration or tissue substitutes, require fabrication approaches that allow the scalability of 3D scaffold for their clinical use. Therefore, both materials and technology need to be optimized and improved. We tackle two research tracks, one to provide high resolution and biocompatible materials that can be used in OPP- mu-SLA, and a second one to obtain a new mu-SLA configuration that can boost large-size scaffold fabrication for tissue engineering applications. In this work, we report our progress towards the formulation of a hydrogel based on the prototype resin X HYDRORES INX X100 from XPECT INX and we describe the configuration based on the beam shaping of a laser source to print centimeter scale scaffolds while conserving micro-scale features. We printed scaffolds with a commercial ABS resin and the bio-inert hydrogel from XPECT INX that allow us to compare resolution, printability, and mechanical stability. Our results evidence structures with voxel widths up to 20 mu m and lengths up to 23 mm by using uniform light sheets illumination patterns. This work set new alternatives for the material and the fabrication aspects of additive manufacturing for 3D biofabrication.}},
  articleno    = {{117860Y}},
  author       = {{Madrid-Sanchez, Alejandro and Van Hoorick, Jasper and Nie, Yunfeng and Duerr, Fabian and Van Vlierberghe, Sandra and Dubruel, Peter and Thienpont, Hugo and Ottevaere, Heidi}},
  booktitle    = {{OPTICAL METHODS FOR INSPECTION, CHARACTERIZATION, AND IMAGING OF BIOMATERIALS V}},
  editor       = {{Ferraro, P. and Grilli, S. and RitschMarte, M. and Hitzenberger, C. K.}},
  isbn         = {{9781510644069}},
  issn         = {{0277-786X}},
  keywords     = {{biofabrication,3D scaffolds,hydrogels,tissue engineering,wound,dressing,micro-stereolithography,one photon polymerization}},
  language     = {{eng}},
  location     = {{Online}},
  pages        = {{7}},
  publisher    = {{SPIE}},
  title        = {{Biomaterials for manufacturing scaffolds : a compromise between resolution, size and biocompatibility}},
  url          = {{http://dx.doi.org/10.1117/12.2593342}},
  volume       = {{11786}},
  year         = {{2021}},
}

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