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Positron emission tomography-based dose painting radiation therapy in a glioblastoma rat model using the small animal radiation research platform

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Abstract
A rat glioblastoma model to mimic chemo-radiation treatment of human glioblastoma in the clinic was previously established. Similar to the clinical treatment, computed tomography (CT) and magnetic resonance imaging (MRI) were combined during the treatment-planning process. Positron emission tomography (PET) imaging was subsequently added to implement sub-volume boosting using a micro-irradiation system. However, combining three imaging modalities (CT, MRI, and PET) using a micro-irradiation system proved to be labor-intensive because multimodal imaging, treatment planning, and dose delivery have to be completed sequentially in the preclinical setting. This also results in a workflow that is more prone to human error. Therefore, a user-friendly algorithm to further optimize preclinical multimodal imagingbased radiation treatment planning was implemented. This software tool was used to evaluate the accuracy and efficiency of dose painting radiation therapy with microirradiation by using an in silico study design. The new methodology for dose painting radiation therapy is superior to the previously described method in terms of accuracy, time efficiency, and intra- and inter-user variability. It is also an important step towards the implementation of inverse treatment planning on micro-irradiators, where forward planning is still commonly used, in contrast to clinical systems.
Keywords
General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Chemical Engineering, General Neuroscience, Article, RESOLUTION, INVERSE, SYSTEM, PET

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MLA
Donche, Sam, et al. “Positron Emission Tomography-Based Dose Painting Radiation Therapy in a Glioblastoma Rat Model Using the Small Animal Radiation Research Platform.” JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, vol. 181, 2022, doi:10.3791/62560.
APA
Donche, S., Verhoeven, J., Descamps, B., Bouckaert, C., Raedt, R., Vanhove, C., & Goethals, I. (2022). Positron emission tomography-based dose painting radiation therapy in a glioblastoma rat model using the small animal radiation research platform. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 181. https://doi.org/10.3791/62560
Chicago author-date
Donche, Sam, Jeroen Verhoeven, Benedicte Descamps, Charlotte Bouckaert, Robrecht Raedt, Christian Vanhove, and Ingeborg Goethals. 2022. “Positron Emission Tomography-Based Dose Painting Radiation Therapy in a Glioblastoma Rat Model Using the Small Animal Radiation Research Platform.” JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 181. https://doi.org/10.3791/62560.
Chicago author-date (all authors)
Donche, Sam, Jeroen Verhoeven, Benedicte Descamps, Charlotte Bouckaert, Robrecht Raedt, Christian Vanhove, and Ingeborg Goethals. 2022. “Positron Emission Tomography-Based Dose Painting Radiation Therapy in a Glioblastoma Rat Model Using the Small Animal Radiation Research Platform.” JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 181. doi:10.3791/62560.
Vancouver
1.
Donche S, Verhoeven J, Descamps B, Bouckaert C, Raedt R, Vanhove C, et al. Positron emission tomography-based dose painting radiation therapy in a glioblastoma rat model using the small animal radiation research platform. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2022;181.
IEEE
[1]
S. Donche et al., “Positron emission tomography-based dose painting radiation therapy in a glioblastoma rat model using the small animal radiation research platform,” JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, vol. 181, 2022.
@article{8747664,
  abstract     = {{A rat glioblastoma model to mimic chemo-radiation treatment of human glioblastoma in the clinic was previously established. Similar to the clinical treatment, computed tomography (CT) and magnetic resonance imaging (MRI) were combined during the treatment-planning process. Positron emission tomography (PET) imaging was subsequently added to implement sub-volume boosting using a micro-irradiation system. However, combining three imaging modalities (CT, MRI, and PET) using a micro-irradiation system proved to be labor-intensive because multimodal imaging, treatment planning, and dose delivery have to be completed sequentially in the preclinical setting. This also results in a workflow that is more prone to human error. Therefore, a user-friendly algorithm to further optimize preclinical multimodal imagingbased radiation treatment planning was implemented. This software tool was used to evaluate the accuracy and efficiency of dose painting radiation therapy with microirradiation by using an in silico study design. The new methodology for dose painting radiation therapy is superior to the previously described method in terms of accuracy, time efficiency, and intra- and inter-user variability. It is also an important step towards the implementation of inverse treatment planning on micro-irradiators, where forward planning is still commonly used, in contrast to clinical systems.}},
  articleno    = {{e62560}},
  author       = {{Donche, Sam and Verhoeven, Jeroen and Descamps, Benedicte and Bouckaert, Charlotte and Raedt, Robrecht and Vanhove, Christian and Goethals, Ingeborg}},
  issn         = {{1940-087X}},
  journal      = {{JOVE-JOURNAL OF VISUALIZED EXPERIMENTS}},
  keywords     = {{General Immunology and Microbiology,General Biochemistry,Genetics and Molecular Biology,General Chemical Engineering,General Neuroscience,Article,RESOLUTION,INVERSE,SYSTEM,PET}},
  language     = {{eng}},
  pages        = {{20}},
  title        = {{Positron emission tomography-based dose painting radiation therapy in a glioblastoma rat model using the small animal radiation research platform}},
  url          = {{http://doi.org/10.3791/62560}},
  volume       = {{181}},
  year         = {{2022}},
}

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