Advanced search
1 file | 345.30 KB Add to list

Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV

(2022) JOURNAL OF INFECTIOUS DISEASES. 225(8). p.1339-1347
Author
Organization
Abstract
The prevalence of clonal hematopoiesis mutations adjusted for age was increased and clone size was larger in people with HIV compared to uninfected controls. These mutations were associated with low CD4 nadir, increased residual HIV-1 transcriptional activity, and coagulation factors. Clonal hematopoiesis, a common age-related phenomenon marked by expansion of cells with clonal hematopoiesis driver mutations, has been associated with all-cause mortality, cancer, and cardiovascular disease. People with HIV (PWH) are at risk for non-AIDS-related comorbidities such as atherosclerotic cardiovascular disease and cancer. In a cross-sectional cohort study, we compared clonal hematopoiesis prevalence in PWH on stable antiretroviral therapy with prevalence in a cohort of overweight individuals and a cohort of age- and sex-matched population controls. The prevalence of clonal hematopoiesis adjusted for age was increased and clone size was larger in PWH compared to population controls. Clonal hematopoiesis is associated with low CD4 nadir, increased residual HIV-1 transcriptional activity, and coagulation factors in PWH. Future studies on the effect of clonal hematopoiesis on the HIV reservoir and non-AIDS-related comorbidities are warranted.
Keywords
MUTATIONS, HIV, clonal hematopoiesis, cART toxicity, coagulation, inflammation

Downloads

  • jiab419.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 345.30 KB

Citation

Please use this url to cite or link to this publication:

MLA
van der Heijden, Wouter A., et al. “Clonal Hematopoiesis Is Associated with Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals with HIV.” JOURNAL OF INFECTIOUS DISEASES, vol. 225, no. 8, 2022, pp. 1339–47, doi:10.1093/infdis/jiab419.
APA
van der Heijden, W. A., van Deuren, R. C., van de Wijer, L., van den Munckhof, I. C. L., Steehouwer, M., Riksen, N. P., … Hoischen, A. (2022). Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV. JOURNAL OF INFECTIOUS DISEASES, 225(8), 1339–1347. https://doi.org/10.1093/infdis/jiab419
Chicago author-date
Heijden, Wouter A. van der, Rosanne C. van Deuren, Lisa van de Wijer, Inge C. L. van den Munckhof, Marloes Steehouwer, Niels P. Riksen, Mihai G. Netea, et al. 2022. “Clonal Hematopoiesis Is Associated with Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals with HIV.” JOURNAL OF INFECTIOUS DISEASES 225 (8): 1339–47. https://doi.org/10.1093/infdis/jiab419.
Chicago author-date (all authors)
van der Heijden, Wouter A., Rosanne C. van Deuren, Lisa van de Wijer, Inge C. L. van den Munckhof, Marloes Steehouwer, Niels P. Riksen, Mihai G. Netea, Quirijn de Mast, Linos Vandekerckhove, Richarda M. de Voer, Andre J. van der Ven, and Alexander Hoischen. 2022. “Clonal Hematopoiesis Is Associated with Low CD4 Nadir and Increased Residual HIV Transcriptional Activity in Virally Suppressed Individuals with HIV.” JOURNAL OF INFECTIOUS DISEASES 225 (8): 1339–1347. doi:10.1093/infdis/jiab419.
Vancouver
1.
van der Heijden WA, van Deuren RC, van de Wijer L, van den Munckhof ICL, Steehouwer M, Riksen NP, et al. Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV. JOURNAL OF INFECTIOUS DISEASES. 2022;225(8):1339–47.
IEEE
[1]
W. A. van der Heijden et al., “Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV,” JOURNAL OF INFECTIOUS DISEASES, vol. 225, no. 8, pp. 1339–1347, 2022.
@article{8747190,
  abstract     = {{The prevalence of clonal hematopoiesis mutations adjusted for age was increased and clone size was larger in people with HIV compared to uninfected controls. These mutations were associated with low CD4 nadir, increased residual HIV-1 transcriptional activity, and coagulation factors. Clonal hematopoiesis, a common age-related phenomenon marked by expansion of cells with clonal hematopoiesis driver mutations, has been associated with all-cause mortality, cancer, and cardiovascular disease. People with HIV (PWH) are at risk for non-AIDS-related comorbidities such as atherosclerotic cardiovascular disease and cancer. In a cross-sectional cohort study, we compared clonal hematopoiesis prevalence in PWH on stable antiretroviral therapy with prevalence in a cohort of overweight individuals and a cohort of age- and sex-matched population controls. The prevalence of clonal hematopoiesis adjusted for age was increased and clone size was larger in PWH compared to population controls. Clonal hematopoiesis is associated with low CD4 nadir, increased residual HIV-1 transcriptional activity, and coagulation factors in PWH. Future studies on the effect of clonal hematopoiesis on the HIV reservoir and non-AIDS-related comorbidities are warranted.}},
  author       = {{van der Heijden, Wouter A. and van Deuren, Rosanne C. and van de Wijer, Lisa and van den Munckhof, Inge C. L. and Steehouwer, Marloes and Riksen, Niels P. and Netea, Mihai G. and de Mast, Quirijn and Vandekerckhove, Linos and de Voer, Richarda M. and van der Ven, Andre J. and Hoischen, Alexander}},
  issn         = {{0022-1899}},
  journal      = {{JOURNAL OF INFECTIOUS DISEASES}},
  keywords     = {{MUTATIONS,HIV,clonal hematopoiesis,cART toxicity,coagulation,inflammation}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1339--1347}},
  title        = {{Clonal hematopoiesis is associated with low CD4 nadir and increased residual HIV transcriptional activity in virally suppressed individuals with HIV}},
  url          = {{http://doi.org/10.1093/infdis/jiab419}},
  volume       = {{225}},
  year         = {{2022}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: