@article{8746094,
  abstract     = {{Background: Consensus about the definition and treatment of oligometastatic oesophagogastric cancer is lacking.

Objective: To assess the definition and treatment of oligometastatic oesophagogastric cancer across multidisciplinary tumour boards (MDTs) in Europe.

Material and methods: European expert centers (n Z 49) were requested to discuss 15 real-life cases in their MDT with at least a medical, surgical, and radiation oncologist present. The cases varied in terms of location and number of metastases, histology, timing of detection (i.e. synchronous versus metachronous), primary tumour treatment status, and response to systemic therapy. The primary outcome was the agreement in the definition of oligometastatic disease at diagnosis and after systemic therapy. The secondary outcome was the agreement in treatment strategies. Treatment strategies for oligometastatic disease were categorised into up -front local treatment (i.e. metastasectomy or stereotactic radiotherapy), systemic therapy followed by restaging to consider local treatment or systemic therapy alone. The agreement across MDTs was scored to be either absent/poor (< 50%), fair (50%-75%), or consensus (>= 75%).

Results: A total of 47 MDTs across 16 countries fully discussed the cases (96%). Oligometastatic disease was considered in patients with 1-2 metastases in either the liver, lung, retroperitoneal lymph nodes, adrenal gland, soft tissue or bone (consensus). At follow-up, oligometastatic disease was considered after a median of 18 weeks of systemic therapy when no progression or progression in size only of the oligometastatic lesion(s) was seen (consensus). If at restaging after a median of 18 weeks of systemic therapy the number of lesions progressed, this was not considered as oligometastatic disease (fair agreement). There was no consensus on treatment strategies for oligometastatic disease.

Conclusion: A broad consensus on definitions of oligometastatic oesophagogastric cancer was found among MDTs of oesophagogastric cancer expert centres in Europe. However, high practice variability in treatment strategies exists. (C) 2022 The Authors. Published by Elsevier Ltd.}},
  author       = {{Kroese, Tiuri E. and van Hillegersberg, Richard and Schoppmann, Sebastian and Deseyne, Pieter and Nafteux, Philippe and Obermannova, Radka and Nordsmark, Marianne and Pfeiffer, Per and Hawkins, Maria A. and Smyth, Elizabeth and Markar, Sheraz and Hanna, George B. and Cheong, Edward and Chaudry, Asif and Elme, Anneli and Adenis, Antoine and Piessen, Guillaume and Gani, Cihan and Bruns, Christiane J. and Moehler, Markus and Liakakos, Theodore and Reynolds, John and Morganti, Alessio and Rosati, Riccardo and Castoro, Carlo and D'Ugo, Domenico and Roviello, Franco and Bencivenga, Maria and de Manzoni, Giovanni and Jeene, Paul and van Sandick, Johanna W. and Muijs, Christel and Slingerland, Marije and Nieuwenhuijzen, Grard and Wijnhoven, Bas and Beerepoot, Laurens V. and Kolodziejczyk, Piotr and Polkowski, Wojciech P. and Alsina, Maria and Pera, Manuel and Kanonnikoff, Tania F. and Nilsson, Magnus and Guckenberger, Matthias and Monig, Stefan and Wagner, Dorethea and Wyrwicz, Lucjan and Berbee, Maaike and Gockel, Ines and Lordick, Florian and Griffiths, Ewen A. and Verheij, Marcel and van Rossum, Peter S.N. and van Laarhoven, Hanneke W.M. and Rosman, Camiel and Rütten, Heide and Gootjes, Elske C. and Vonken, Francine E.M. and van Dieren, Jolanda M. and Vollebergh, Marieke A. and van der Sangen, Maurice and Creemers, Geert-Jan and Zander, Thomas and Schlößer, Hans and Cascinu, Stefano and Mazza, Elena and Nicoletti, Roberto and Damascelli, Anna and Slim, Najla and Passoni, Paolo and Cossu, Andrea and Puccetti, Francesco and Barbieri, Lavinia and Fanti, Lorella and Azzolini, Francesco and Ventoruzzo, Federico and Szczepanik, Antoni and Visa, Laura and Reig, Anna and Roques, Tom and Harrison, Mark and Ciseł, Bogumiła and Pikuła, Agnieszka and Skórzewska, Magdalena and Vanommeslaeghe, Hanne and Van Daele, Elke and Pattyn, Piet and Geboes, Karen and Callebout, Eduard and Moura Ribeiro, Suzane and van Duijvendijk, Peter and Tromp, Cathrien and Sosef, Meindert and Warmerdam, Fabienne and Heisterkamp, Joos and Heisterkamp, Joos and Vera, Almudena and Jordá, Esther and López-Mozos, Fernando and Fernandez-Moreno, Maria C. and Barrios-Carvajal, Maria and Huerta, Marisol and de Steur, Wobbe and Lips, Irene and Diez, Marc and Castro, Sandra and O'Neill, Robert and Holyoake, Daniel and Hacker, Ulrich and Denecke, Timm and Kuhnt, Thomas and Hoffmeister, Albrecht and Kluge, Regine and Bostel, Tilman and Grimminger, Peter and Jedlička, Václav and Křístek, Jan and Pospíšil, Petr and Mourregot, Anne and Maurin, Clotilde and Starling, Naureen and Chong, Irene}},
  issn         = {{0959-8049}},
  journal      = {{EUROPEAN JOURNAL OF CANCER}},
  keywords     = {{Cancer Research,Oncology,Oesophageal neoplasm,Gastric neoplasm,Neoplasm metastasis,Metastasectomy,Radiosurgery,Oligometastasis,SURGICAL RESECTION,SURVIVAL,CHEMOTHERAPY,JUNCTION}},
  language     = {{eng}},
  pages        = {{18--29}},
  title        = {{Definitions and treatment of oligometastatic oesophagogastric cancer according to multidisciplinary tumour boards in Europe}},
  url          = {{http://doi.org/10.1016/j.ejca.2021.11.032}},
  volume       = {{164}},
  year         = {{2022}},
}

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