Advanced search
1 file | 1.44 MB Add to list

Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position

Pieter Deseyne (UGent) , Bruno Speleers (UGent) , Leen Paelinck (UGent) , Werner De Gersem (UGent) , Wilfried De Neve (UGent) , Max Schoepen (UGent) , Annick Van Greveling (UGent) , Hans Van Hulle, Vincent Vakaet (UGent) , Giselle Post (UGent) , et al.
Author
Organization
Abstract
In whole breast and regional nodal irradiation (WB + RNI), breathhold increases organ at risk (OAR) sparing. WB + RNI is usually performed in supine position, because positioning materials obstruct beam paths in prone position. Recent advancements allow prone WB + RNI (pWB + RNI) with increased sparing of OARs compared to supine WB + RNI. We evaluate positional and dosimetrical impact of repeated breathhold (RBH) and failure to breathhold (FTBH) in pWB + RNI. Twenty left-sided breast cancer patients were scanned twice in breathhold (baseline and RBH) and once free breathing (i.e. FTBH). Positional impact was evaluated using overlap index (OI) and Dice similarity coefficient (DSC). Dosimetrical impact was assessed by beam transposition from the baseline plan. Mean OI and DSC ranges were 0.01-0.98 and 0.01-0.92 for FTBH, and 0.73-1 and 0.69-1 for RBH. Dosimetric impact of RBH was negligible. FTBH significantly decreased minimal dose to CTV WBI, level II and the internal mammary nodes, with adequate mean doses. FTBH significantly increased heart, LAD, left lung and esophagus dose. OI and DSC for RBH and FTBH show reproducible large ROI positions. Small ROIs show poor overlap. FTBH maintained adequate target coverage but increased heart, LAD, ipsilateral lung and esophagus dose. RBH is a robust technique in pWB + RNI. (Clinicaltrials.gov: NCT05179161, registered 05/01/2022).
Keywords
Multidisciplinary, ELECTIVE RADIATION-THERAPY, ESTRO CONSENSUS GUIDELINE, TARGET VOLUME DELINEATION, LYMPH-NODES, CANCER, HOLD, HEART, RADIOTHERAPY, MULTICENTER, VALIDATION

Downloads

  • published.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 1.44 MB

Citation

Please use this url to cite or link to this publication:

MLA
Deseyne, Pieter, et al. “Reproducibility of Repeated Breathhold and Impact of Breathhold Failure in Whole Breast and Regional Nodal Irradiation in Prone Crawl Position.” SCIENTIFIC REPORTS, vol. 12, no. 1, 2022, doi:10.1038/s41598-022-05957-7.
APA
Deseyne, P., Speleers, B., Paelinck, L., De Gersem, W., De Neve, W., Schoepen, M., … Veldeman, L. (2022). Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position. SCIENTIFIC REPORTS, 12(1). https://doi.org/10.1038/s41598-022-05957-7
Chicago author-date
Deseyne, Pieter, Bruno Speleers, Leen Paelinck, Werner De Gersem, Wilfried De Neve, Max Schoepen, Annick Van Greveling, et al. 2022. “Reproducibility of Repeated Breathhold and Impact of Breathhold Failure in Whole Breast and Regional Nodal Irradiation in Prone Crawl Position.” SCIENTIFIC REPORTS 12 (1). https://doi.org/10.1038/s41598-022-05957-7.
Chicago author-date (all authors)
Deseyne, Pieter, Bruno Speleers, Leen Paelinck, Werner De Gersem, Wilfried De Neve, Max Schoepen, Annick Van Greveling, Hans Van Hulle, Vincent Vakaet, Giselle Post, Christel Monten, Herman Depypere, and Liv Veldeman. 2022. “Reproducibility of Repeated Breathhold and Impact of Breathhold Failure in Whole Breast and Regional Nodal Irradiation in Prone Crawl Position.” SCIENTIFIC REPORTS 12 (1). doi:10.1038/s41598-022-05957-7.
Vancouver
1.
Deseyne P, Speleers B, Paelinck L, De Gersem W, De Neve W, Schoepen M, et al. Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position. SCIENTIFIC REPORTS. 2022;12(1).
IEEE
[1]
P. Deseyne et al., “Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position,” SCIENTIFIC REPORTS, vol. 12, no. 1, 2022.
@article{8746092,
  abstract     = {{In whole breast and regional nodal irradiation (WB + RNI), breathhold increases organ at risk (OAR) sparing. WB + RNI is usually performed in supine position, because positioning materials obstruct beam paths in prone position. Recent advancements allow prone WB + RNI (pWB + RNI) with increased sparing of OARs compared to supine WB + RNI. We evaluate positional and dosimetrical impact of repeated breathhold (RBH) and failure to breathhold (FTBH) in pWB + RNI. Twenty left-sided breast cancer patients were scanned twice in breathhold (baseline and RBH) and once free breathing (i.e. FTBH). Positional impact was evaluated using overlap index (OI) and Dice similarity coefficient (DSC). Dosimetrical impact was assessed by beam transposition from the baseline plan. Mean OI and DSC ranges were 0.01-0.98 and 0.01-0.92 for FTBH, and 0.73-1 and 0.69-1 for RBH. Dosimetric impact of RBH was negligible. FTBH significantly decreased minimal dose to CTV WBI, level II and the internal mammary nodes, with adequate mean doses. FTBH significantly increased heart, LAD, left lung and esophagus dose. OI and DSC for RBH and FTBH show reproducible large ROI positions. Small ROIs show poor overlap. FTBH maintained adequate target coverage but increased heart, LAD, ipsilateral lung and esophagus dose. RBH is a robust technique in pWB + RNI. (Clinicaltrials.gov: NCT05179161, registered 05/01/2022).}},
  articleno    = {{1887}},
  author       = {{Deseyne, Pieter and Speleers, Bruno and Paelinck, Leen and De Gersem, Werner and De Neve, Wilfried and Schoepen, Max and Van Greveling, Annick and Van Hulle, Hans and Vakaet, Vincent and Post, Giselle and Monten, Christel and Depypere, Herman and Veldeman, Liv}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{Multidisciplinary,ELECTIVE RADIATION-THERAPY,ESTRO CONSENSUS GUIDELINE,TARGET VOLUME DELINEATION,LYMPH-NODES,CANCER,HOLD,HEART,RADIOTHERAPY,MULTICENTER,VALIDATION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{Reproducibility of repeated breathhold and impact of breathhold failure in whole breast and regional nodal irradiation in prone crawl position}},
  url          = {{http://doi.org/10.1038/s41598-022-05957-7}},
  volume       = {{12}},
  year         = {{2022}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: