Viral manipulation of host cell necroptosis and pyroptosis
- Author
- Simon Verdonck (UGent) , Josephine Nemegeer (UGent) , Peter Vandenabeele (UGent) and Jonathan Maelfait (UGent)
- Organization
- Project
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- MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection
- Unraveling the in vivo role of RIPK1: Physiological and pathological consequences of kinase-dependent and kinase-independent functions
- Factors that determine RIPK1-dependent necroptosis
- Investigating the role of ferroptosis in acute liver injury and multiple sclerosis with newly developed chemical tool compounds
- Thymic reprogramming: The role of Death Receptor 3 (DR3)
- Cell death activity regulation in inflammation and cancer
- Study of Z-RNA in antiviral programmed cell death and immune dysregulation
- Investigating the immunoregulatory properties of ferroptosis in experimental cancer models
- Sensing of viral Z-RNA by ZBP1
- Abstract
- Cell death forms an essential component of the antiviral immune response. Viral infection elicits different forms of host cell death, including the lytic and inflammatory cell death modes necroptosis or pyroptosis. The induction of both types of cell death not only eliminates virus-infected cells but also contributes to the development of innate and adaptive immunity through the release of inflammatory mediators. The importance of necroptosis and pyroptosis in host defence is evident from the numerous viral evasion mechanisms that suppress these cell death pathways. Here, we review the emerging principles by which viruses antagonise host cell necroptosis and pyroptosis to promote their spread and block host immunity.
- Keywords
- Virology, Infectious Diseases, Microbiology (medical), Microbiology, PROGRAMMED NECROSIS, VIRUS ENCODES, COWPOX VIRUS, DEATH, PROTEIN, APOPTOSIS, CYTOMEGALOVIRUS, INFLAMMASOME, INHIBITION, VACCINIA
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8745102
- MLA
- Verdonck, Simon, et al. “Viral Manipulation of Host Cell Necroptosis and Pyroptosis.” TRENDS IN MICROBIOLOGY, vol. 30, no. 6, 2022, pp. 593–605, doi:10.1016/j.tim.2021.11.011.
- APA
- Verdonck, S., Nemegeer, J., Vandenabeele, P., & Maelfait, J. (2022). Viral manipulation of host cell necroptosis and pyroptosis. TRENDS IN MICROBIOLOGY, 30(6), 593–605. https://doi.org/10.1016/j.tim.2021.11.011
- Chicago author-date
- Verdonck, Simon, Josephine Nemegeer, Peter Vandenabeele, and Jonathan Maelfait. 2022. “Viral Manipulation of Host Cell Necroptosis and Pyroptosis.” TRENDS IN MICROBIOLOGY 30 (6): 593–605. https://doi.org/10.1016/j.tim.2021.11.011.
- Chicago author-date (all authors)
- Verdonck, Simon, Josephine Nemegeer, Peter Vandenabeele, and Jonathan Maelfait. 2022. “Viral Manipulation of Host Cell Necroptosis and Pyroptosis.” TRENDS IN MICROBIOLOGY 30 (6): 593–605. doi:10.1016/j.tim.2021.11.011.
- Vancouver
- 1.Verdonck S, Nemegeer J, Vandenabeele P, Maelfait J. Viral manipulation of host cell necroptosis and pyroptosis. TRENDS IN MICROBIOLOGY. 2022;30(6):593–605.
- IEEE
- [1]S. Verdonck, J. Nemegeer, P. Vandenabeele, and J. Maelfait, “Viral manipulation of host cell necroptosis and pyroptosis,” TRENDS IN MICROBIOLOGY, vol. 30, no. 6, pp. 593–605, 2022.
@article{8745102,
abstract = {{Cell death forms an essential component of the antiviral immune response. Viral infection elicits different forms of host cell death, including the lytic and inflammatory cell death modes necroptosis or pyroptosis. The induction of both types of cell death not only eliminates virus-infected cells but also contributes to the development of innate and adaptive immunity through the release of inflammatory mediators. The importance of necroptosis and pyroptosis in host defence is evident from the numerous viral evasion mechanisms that suppress these cell death pathways. Here, we review the emerging principles by which viruses antagonise host cell necroptosis and pyroptosis to promote their spread and block host immunity.}},
author = {{Verdonck, Simon and Nemegeer, Josephine and Vandenabeele, Peter and Maelfait, Jonathan}},
issn = {{0966-842X}},
journal = {{TRENDS IN MICROBIOLOGY}},
keywords = {{Virology,Infectious Diseases,Microbiology (medical),Microbiology,PROGRAMMED NECROSIS,VIRUS ENCODES,COWPOX VIRUS,DEATH,PROTEIN,APOPTOSIS,CYTOMEGALOVIRUS,INFLAMMASOME,INHIBITION,VACCINIA}},
language = {{eng}},
number = {{6}},
pages = {{593--605}},
title = {{Viral manipulation of host cell necroptosis and pyroptosis}},
url = {{http://doi.org/10.1016/j.tim.2021.11.011}},
volume = {{30}},
year = {{2022}},
}
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