Activation of fibroblasts in skin cancer
- Author
- Lisette Van Hove and Esther Hoste (UGent)
- Organization
- Project
- Abstract
- Fibroblasts have emerged as a dominant component of the tumor microenvironment, but despite the surging interest in the activation of fibroblasts and their role in cancer, they remain an elusive and complex cell type. In this perspective, we discuss the phenotypic plasticity of cancer-associated fibroblasts (CAFs) in melanoma and nonmelanoma skin cancer identified by genome-wide transcriptomic studies and focus on the molecular pathways underlying their activation. These studies reveal distinct fibroblast activation profiles depending on tumor type and stage. A better understanding of skin CAF heterogeneity in origin and function will guide novel therapeutic approaches targeting this cell type in clinical cancer care.
- Keywords
- Cell Biology, Dermatology, Molecular Biology, Biochemistry, TUMOR, EXPRESSION, MELANOMA, MATRIX, GROWTH, CELLS, HEAD, PROGRESSION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8744981
- MLA
- Van Hove, Lisette, and Esther Hoste. “Activation of Fibroblasts in Skin Cancer.” JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 142, no. 4, 2022, pp. 1026–31, doi:10.1016/j.jid.2021.09.010.
- APA
- Van Hove, L., & Hoste, E. (2022). Activation of fibroblasts in skin cancer. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 142(4), 1026–1031. https://doi.org/10.1016/j.jid.2021.09.010
- Chicago author-date
- Van Hove, Lisette, and Esther Hoste. 2022. “Activation of Fibroblasts in Skin Cancer.” JOURNAL OF INVESTIGATIVE DERMATOLOGY 142 (4): 1026–31. https://doi.org/10.1016/j.jid.2021.09.010.
- Chicago author-date (all authors)
- Van Hove, Lisette, and Esther Hoste. 2022. “Activation of Fibroblasts in Skin Cancer.” JOURNAL OF INVESTIGATIVE DERMATOLOGY 142 (4): 1026–1031. doi:10.1016/j.jid.2021.09.010.
- Vancouver
- 1.Van Hove L, Hoste E. Activation of fibroblasts in skin cancer. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(4):1026–31.
- IEEE
- [1]L. Van Hove and E. Hoste, “Activation of fibroblasts in skin cancer,” JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 142, no. 4, pp. 1026–1031, 2022.
@article{8744981,
abstract = {{Fibroblasts have emerged as a dominant component of the tumor microenvironment, but despite the surging
interest in the activation of fibroblasts and their role in cancer, they remain an elusive and complex cell type. In
this perspective, we discuss the phenotypic plasticity of cancer-associated fibroblasts (CAFs) in melanoma and
nonmelanoma skin cancer identified by genome-wide transcriptomic studies and focus on the molecular
pathways underlying their activation. These studies reveal distinct fibroblast activation profiles depending on
tumor type and stage. A better understanding of skin CAF heterogeneity in origin and function will guide novel
therapeutic approaches targeting this cell type in clinical cancer care.}},
author = {{Van Hove, Lisette and Hoste, Esther}},
issn = {{0022-202X}},
journal = {{JOURNAL OF INVESTIGATIVE DERMATOLOGY}},
keywords = {{Cell Biology,Dermatology,Molecular Biology,Biochemistry,TUMOR,EXPRESSION,MELANOMA,MATRIX,GROWTH,CELLS,HEAD,PROGRESSION}},
language = {{eng}},
number = {{4}},
pages = {{1026--1031}},
title = {{Activation of fibroblasts in skin cancer}},
url = {{http://doi.org/10.1016/j.jid.2021.09.010}},
volume = {{142}},
year = {{2022}},
}
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