Effects of deoxynivalenol and fumonisins on broiler gut cytoprotective capacity
- Author
- Vasileios Paraskeuas, Eirini Griela, Dimitrios Bouziotis, Konstantinos Fegeros, Gunther Antonissen (UGent) and Konstantinos C. Mountzouris
- Organization
- Abstract
- Mycotoxins are a crucial problem for poultry production worldwide. Two of the most frequently found mycotoxins in feedstuffs are deoxynivalenol (DON) and fumonisins (FUM) which adversely affect gut health and poultry performance. The current knowledge on DON and FUM effects on broiler responses relevant for gut detoxification, antioxidant capacity, and health is still unclear. The aim of this study was to assess a range of selected molecular intestinal biomarkers for their responsiveness to the maximum allowable European Union dietary levels for DON (5 mg/kg) and FUM (20 mg/kg) in broilers. For the experimental purpose, a challenge diet was formulated, and biomarkers relevant for detoxification, antioxidant response, stress, inflammation, and integrity were profiled across the broiler intestine. The results reveal that DON significantly (p < 0.05) induced aryl hydrocarbon receptor (AhR) and cytochrome P450 enzyme (CYP) expression mainly at the duodenum. Moreover, DON and FUM had specific significant (p < 0.05) effects on the antioxidant response, stress, inflammation, and integrity depending on the intestinal segment. Consequently, broiler molecular responses to DON and FUM assessed via a powerful palette of biomarkers were shown to be mycotoxin and intestinal site specific. The study findings could be highly relevant for assessing various dietary bioactive components for protection against mycotoxins.
- Keywords
- ARYL-HYDROCARBON RECEPTOR, ANTIOXIDANT CAPACITY, OXIDATIVE STRESS, PHYTOGENIC INCLUSION, FUSARIUM-MYCOTOXINS, HEAT-STRESS, PERFORMANCE, IMPACT, MORPHOLOGY, PHYTOCHEMICALS, mycotoxins, broilers, gut health, antioxidant response, detoxification, inflammation
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8743822
- MLA
- Paraskeuas, Vasileios, et al. “Effects of Deoxynivalenol and Fumonisins on Broiler Gut Cytoprotective Capacity.” TOXINS, vol. 13, no. 10, 2021, doi:10.3390/toxins13100729.
- APA
- Paraskeuas, V., Griela, E., Bouziotis, D., Fegeros, K., Antonissen, G., & Mountzouris, K. C. (2021). Effects of deoxynivalenol and fumonisins on broiler gut cytoprotective capacity. TOXINS, 13(10). https://doi.org/10.3390/toxins13100729
- Chicago author-date
- Paraskeuas, Vasileios, Eirini Griela, Dimitrios Bouziotis, Konstantinos Fegeros, Gunther Antonissen, and Konstantinos C. Mountzouris. 2021. “Effects of Deoxynivalenol and Fumonisins on Broiler Gut Cytoprotective Capacity.” TOXINS 13 (10). https://doi.org/10.3390/toxins13100729.
- Chicago author-date (all authors)
- Paraskeuas, Vasileios, Eirini Griela, Dimitrios Bouziotis, Konstantinos Fegeros, Gunther Antonissen, and Konstantinos C. Mountzouris. 2021. “Effects of Deoxynivalenol and Fumonisins on Broiler Gut Cytoprotective Capacity.” TOXINS 13 (10). doi:10.3390/toxins13100729.
- Vancouver
- 1.Paraskeuas V, Griela E, Bouziotis D, Fegeros K, Antonissen G, Mountzouris KC. Effects of deoxynivalenol and fumonisins on broiler gut cytoprotective capacity. TOXINS. 2021;13(10).
- IEEE
- [1]V. Paraskeuas, E. Griela, D. Bouziotis, K. Fegeros, G. Antonissen, and K. C. Mountzouris, “Effects of deoxynivalenol and fumonisins on broiler gut cytoprotective capacity,” TOXINS, vol. 13, no. 10, 2021.
@article{8743822, abstract = {{Mycotoxins are a crucial problem for poultry production worldwide. Two of the most frequently found mycotoxins in feedstuffs are deoxynivalenol (DON) and fumonisins (FUM) which adversely affect gut health and poultry performance. The current knowledge on DON and FUM effects on broiler responses relevant for gut detoxification, antioxidant capacity, and health is still unclear. The aim of this study was to assess a range of selected molecular intestinal biomarkers for their responsiveness to the maximum allowable European Union dietary levels for DON (5 mg/kg) and FUM (20 mg/kg) in broilers. For the experimental purpose, a challenge diet was formulated, and biomarkers relevant for detoxification, antioxidant response, stress, inflammation, and integrity were profiled across the broiler intestine. The results reveal that DON significantly (p < 0.05) induced aryl hydrocarbon receptor (AhR) and cytochrome P450 enzyme (CYP) expression mainly at the duodenum. Moreover, DON and FUM had specific significant (p < 0.05) effects on the antioxidant response, stress, inflammation, and integrity depending on the intestinal segment. Consequently, broiler molecular responses to DON and FUM assessed via a powerful palette of biomarkers were shown to be mycotoxin and intestinal site specific. The study findings could be highly relevant for assessing various dietary bioactive components for protection against mycotoxins.}}, articleno = {{729}}, author = {{Paraskeuas, Vasileios and Griela, Eirini and Bouziotis, Dimitrios and Fegeros, Konstantinos and Antonissen, Gunther and Mountzouris, Konstantinos C.}}, issn = {{2072-6651}}, journal = {{TOXINS}}, keywords = {{ARYL-HYDROCARBON RECEPTOR,ANTIOXIDANT CAPACITY,OXIDATIVE STRESS,PHYTOGENIC INCLUSION,FUSARIUM-MYCOTOXINS,HEAT-STRESS,PERFORMANCE,IMPACT,MORPHOLOGY,PHYTOCHEMICALS,mycotoxins,broilers,gut health,antioxidant response,detoxification,inflammation}}, language = {{eng}}, number = {{10}}, pages = {{19}}, title = {{Effects of deoxynivalenol and fumonisins on broiler gut cytoprotective capacity}}, url = {{http://doi.org/10.3390/toxins13100729}}, volume = {{13}}, year = {{2021}}, }
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