@article{8743039,
  abstract     = {{Purpose The number of patients >= 80 years admitted into critical care is increasing. Coronavirus disease 2019 (COVID-19) added another challenge for clinical decisions for both admission and limitation of life-sustaining treatments (LLST). We aimed to compare the characteristics and mortality of very old critically ill patients with or without COVID-19 with a focus on LLST. Methods Patients 80 years or older with acute respiratory failure were recruited from the VIP2 and COVIP studies. Baseline patient characteristics, interventions in intensive care unit (ICU) and outcomes (30-day survival) were recorded. COVID patients were matched to non-COVID patients based on the following factors: age (+/- 2 years), Sequential Organ Failure Assessment (SOFA) score (+/- 2 points), clinical frailty scale (+/- 1 point), gender and region on a 1:2 ratio. Specific ICU procedures and LLST were compared between the cohorts by means of cumulative incidence curves taking into account the competing risk of discharge and death. Results 693 COVID patients were compared to 1393 non-COVID patients. COVID patients were younger, less frail, less severely ill with lower SOFA score, but were treated more often with invasive mechanical ventilation (MV) and had a lower 30-day survival. 404 COVID patients could be matched to 666 non-COVID patients. For COVID patients, withholding and withdrawing of LST were more frequent than for non-COVID and the 30-day survival was almost half compared to non-COVID patients. Conclusion Very old COVID patients have a different trajectory than non-COVID patients. Whether this finding is due to a decision policy with more active treatment limitation or to an inherent higher risk of death due to COVID-19 is unclear.}},
  author       = {{Guidet, Bertrand and Jung, Christian and Flaatten, Hans and Fjølner, Jesper and Artigas, Antonio and Pinto, Bernardo Bollen and Schefold, Joerg C. and Beil, Michael and Sigal, Sviri and van Heerden, Peter Vernon and Szczeklik, Wojciech and Joannidis, Michael and Oeyen, Sandra and Kondili, Eumorfia and Marsh, Brian and Andersen, Finn H. and Moreno, Rui and Cecconi, Maurizio and Leaver, Susannah and De Lange, Dylan W. and Boumendil, Ariane and Eller, Philipp and Joannidis, Michael and Mesotten, Dieter and Reper, Pascal and Swinnen, Walter and Brix, Helene and Brushoej, Jens and Villefrance, Maja and Nedergaard, Helene Korvenius and Bjerregaard, Anders Thais and Balleby, Ida Riise and Andersen, Kasper and Hansen, Maria Aagaard and Uhrenholt, Stine and Bundgaard, Helle and Fjølner, Jesper and Hussein, Aliae A. R. Mohamed and Salah, Rehab and Ali, Yasmin Khairy Nasr Eldin Mohamed and Wassim, Kyrillos and Elgazzar, Yumna A and Tharwat, Samar and Azzam, Ahmed Y. and Habib, Ayman Abdelmawgoad and Abosheaishaa, Hazem Maarouf and Azab, Mohammed A. and Leaver, Susannah and Galbois, Arnaud and Urbina, Tomas and Charron, Cyril and Guerot, Emmanuel and Besch, Guillaume and Rigaud, Jean-Philippe and Maizel, Julien and Djibré, Michel and Burtin, Philippe and Garcon, Pierre and Nseir, Saad and Valette, Xavier and Alexandru, Nica and Marin, Nathalie and Vaissiere, Marie and Plantefeve, Gaëtan and Vanderlinden, Thierry and Jurcisin, Igor and Megarbane, Buno and Caillard, Anais and Valent, Arnaud and Garnier, Marc and Besset, Sebastien and Oziel, Johanna and Raphalen, Jean-herlé and Dauger, Stéphane and Dumas, Guillaume and Goncalves, Bruno and Piton, Gaël and Barth, Eberhard and Goebel, Ulrich and Barth, Eberhard and Kunstein, Anselm and Schuster, Michael and Welte, Martin and Lutz, Matthias and Meybohm, Patrick and Steiner, Stephan and Poerner, Tudor and Haake, Hendrik and Schaller, Stefan and Schaller, Stefan and Schaller, Stefan and Kindgen-Milles, Detlef and Meyer, Christian and Kurt, Muhammed and Kuhn, Karl Friedrich and Randerath, Winfried and Wollborn, Jakob and Dindane, Zouhir and Kabitz, Hans-Joachim and Voigt, Ingo and Shala, Gonxhe and Faltlhauser, Andreas and Rovina, Nikoletta and Aidoni, Zoi and Chrisanthopoulou, Evangelia and Papadogoulas, Antonios and Gurjar, Mohan and Mahmoodpoor, Ata and Ahmed, Abdullah Khudhur and Marsh, Brian and Elsaka, Ahmed and Sviri, Sigal and Comellini, Vittoria and Rabha, Ahmed and Ahmed, Hazem and Namendys-Silva, Silvio A. and Ghannam, Abdelilah and Groenendijk, Martijn and Zegers, Marieke and de Lange, Dylan and Cornet, Alex and Evers, Mirjam and Haas, Lenneke and Dormans, Tom and Dieperink, Willem and Romundstad, Luis and Sjøbø, Britt and Andersen, Finn H. and Strietzel, Hans Frank and Olasveengen, Theresa and Hahn, Michael and Czuczwar, Miroslaw and Gawda, Ryszard and Klimkiewicz, Jakub and Santos, Maria de Lurdes Campos and Gordinho, André and Santos, Henrique and Assis, Rui and Oliveira, Ana Isabel Pinho and Badawy, Mohamed Raafat and Perez-Torres, David and Gomà, Gemma and Villamayor, Mercedes Ibarz and Mira, Angela Prado and Cubero, Patricia Jimeno and Rivera, Susana Arias and Tomasa, Teresa and Iglesias, David and Vázquez, Eric Mayor and Aldecoa, Cesar and Ferreira, Aida Fernández and Zalba-Etayo, Begoña and Canas-Perez, Isabel and Tamayo-Lomas, Luis and Diaz-Rodriguez, Cristina and Sancho, Susana and Priego, Jesús and Abualqumboz, Enas M. Y. and Hilles, Momin Majed Yousuf and Saleh, Mahmoud and Ben-Hamouda, Nawfel and Roberti, Andrea and Dullenkopf, Alexander and Fleury, Yvan and Pinto, Bernardo Bollen and Schefold, Joerg C. and Al-Sadaw, Mohammed and the VIP2 and COVIP study groups, [missing]}},
  issn         = {{0342-4642}},
  journal      = {{INTENSIVE CARE MEDICINE}},
  keywords     = {{Critical Care and Intensive Care Medicine,Old patients,COVID,Intensive care,Treatment limitation,Mortality,INTENSIVE-CARE UNITS,BED AVAILABILITY,ILL PATIENTS,FRAILTY,OUTCOMES}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{435--447}},
  title        = {{Increased 30-day mortality in very old ICU patients with COVID-19 compared to patients with respiratory failure without COVID-19}},
  url          = {{http://doi.org/10.1007/s00134-022-06642-z}},
  volume       = {{48}},
  year         = {{2022}},
}

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