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Health-related quality of life in older patients surviving ICU treatment for COVID-19 : results from an international observational study of patients older than 70 years

(2022) AGE AND AGEING. 51(2).
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Organization
Abstract
Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. Objective to quantify HRQoL in order to identify areas of interventions. Design prospective observation study. Setting admissions to European ICUs between March 2020 and February 2021. Subjects patients aged 70 years or older admitted with COVID-19 disease. Methods collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of >= 4 on any of Euro-QoL-5D-5L domains was considered unfavourable. Results in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71-1.87) for CFS 2 to OR 4.33 (95% CI: 1.57-11.9) for CFS >= 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months. Conclusions in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.
Keywords
Geriatrics and Gerontology, Aging, General Medicine, Intensive Care Unit (ICU), frailty, Quality of Life, Survival, Older people, COVID-19, INTENSIVE-CARE, SOCIETY

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MLA
Soliman, Ivo W., et al. “Health-Related Quality of Life in Older Patients Surviving ICU Treatment for COVID-19 : Results from an International Observational Study of Patients Older than 70 Years.” AGE AND AGEING, vol. 51, no. 2, 2022, doi:10.1093/ageing/afab278.
APA
Soliman, I. W., Leaver, S., Flaatten, H., Fjølner, J., Wernly, B., Bruno, R. R., … The COVIP-study group, [missing]. (2022). Health-related quality of life in older patients surviving ICU treatment for COVID-19 : results from an international observational study of patients older than 70 years. AGE AND AGEING, 51(2). https://doi.org/10.1093/ageing/afab278
Chicago author-date
Soliman, Ivo W, Susannah Leaver, Hans Flaatten, Jesper Fjølner, Bernhard Wernly, Raphael R Bruno, Antonio Artigas, et al. 2022. “Health-Related Quality of Life in Older Patients Surviving ICU Treatment for COVID-19 : Results from an International Observational Study of Patients Older than 70 Years.” AGE AND AGEING 51 (2). https://doi.org/10.1093/ageing/afab278.
Chicago author-date (all authors)
Soliman, Ivo W, Susannah Leaver, Hans Flaatten, Jesper Fjølner, Bernhard Wernly, Raphael R Bruno, Antonio Artigas, Bernardo Bollen Pinto, Joerg C Schefold, Michael Beil, Sigal Sviri, Peter Vernon van Heerden, Wojciech Szczeklik, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Jakob Wollborn, Maria Jose Arche Banzo, Kristina Fuest, Brian Marsh, Finn H Andersen, Rui Moreno, Ariane Boumendil, Bertrand Guidet, Christian Jung, Dylan W De Lange, Philipp Eller, Michael Joannidis, Dieter Mesotten, Pascal Reper, Walter Swinnen, Helene Brix, Jens Brushoej, Maja Villefrance, Helene Korvenius Nedergaard, Anders Thais Bjerregaard, Ida Riise Balleby, Kasper Andersen, Maria Aagaard Hansen, Stine Uhrenholt, Helle Bundgaard, Jesper Fjølner, Aliae Ar Hussein Mohamed, Rehab Salah, Yasmin Khairy NasrEldin Mohamed Ali, Kyrillos Wassim, Yumna A Elgazzar, Samar Tharwat, Ahmed Y Azzam, Ayman Abdelmawgoad Habib, Hazem Maarouf Abosheaishaa, Mohammed A Azab, Susannah Leaver, Arnaud Galbois, Bertrand Guidet, Cyril Charron, Emmanuel Guerot, Guillaume Besch, Jean-Philippe Rigaud, Julien Maizel, Michel Djibré, Philippe Burtin, Pierre Garcon, Saad Nseir, Xavier Valette, Nica Alexandru, Nathalie Marin, Marie Vaissiere, Gaëtan Plantefeve, Thierry Vanderlinden, Igor Jurcisin, Bruno Megarbane, Anais Caillard, Arnaud Valent, Marc Garnier, Sebastien Besset, Johanna Oziel, Jean-Herlé Raphaelen, Stéphane Dauger, Guillaume Dumas, Bruno Goncalves, Gaël Piton, Christian Jung, Raphael Romano Bruno, Malte Kelm, Georg Wolff, Eberhard Barth, Ulrich Goebel, Eberhard Barth, Anselm Kunstein, Michael Schuster, Martin Welte, Matthias Lutz, Patrick Meybohm, Stephan Steiner, Tudor Poerner, Hendrik Haake, Stefan Schaller, Detlef Kindgen-Milles, Christian Meyer, Muhammed Kurt, Karl Friedrich Kuhn, Winfried Randerath, Jakob Wollborn, Zouhir Dindane, Hans-Joachim Kabitz, Ingo Voigt, Gonxhe Shala, Andreas Faltlhauser, Nikoletta Rovina, Zoi Aidoni, Evangelia Chrisanthopoulou, Antonios Papadogoulas, Mohan Gurjar, Ata Mahmoodpoor, Abdullah Khudhur Ahmed, Brian Marsh, Ahmed Elsaka, Sigal Sviri, Vittoria Comellini, Ahmed Rabha, Hazem Ahmed, Silvio A Namendys-Silva, Abdelilah Ghannam, Martijn Groenendijk, Marieke Zegers, Dylan de Lange, Alex Cornet, Mirjam Evers, Lenneke Haas, Tom Dormans, Willem Dieperink, Luis Romundstad, Britt Sjøbø, Finn H Andersen, Hans Frank Strietzel, Theresa Olasveengen, Michael Hahn, Miroslaw Czuczwar, Ryszard Gawda, Jakub Klimkiewicz, Maria Campos de LurdesSantos, André Gordinho, Henrique Santos, Rui Assis, Ana Isabel Pinho Oliveira, Mohamed Raafat Badawy, David Perez-Torres, Gemma Gomà, Mercedes Ibarz Villamayor, Angela Prado Mira, Patricia Jimeno Cubero, Susana Arias Rivera, Teresa Tomasa, David Iglesias, Eric Mayor Vázquez, Cesar Aldecoa, Aida Fernández Ferreira, Begoña Zalba-Etayo, Isabel Canas-Perez, Luis Tamayo-Lomas, Cristina Diaz-Rodriguez, Susana Sancho, Jesús Priego, Enas M Y Abualqumboz, Momin Majed Yousuf Hilles, Mahmoud Saleh, Nawfel Ben-HAmouda, Andrea Roberti, Alexander Dullenkopf, Yvan Fleury, Bernardo Bollen Pinto, Joerg C Schefold, Mohammed Al-Sadawi, Nicolas Serck, Elisabeth Dewaele, Pritpal Kumar, Camilla Bundesen, Richard Innes, James Gooch, Lenka Cagova, Elizabeth Potter, Michael Reay, Miriam Davey, Sally Humphreys, Caroline Hauw Berlemont, Benjamin Glenn Chousterman, François Dépret, Alexis Ferre, Lucie Vettoretti, Didier Thevenin, Andreas Faltlhauser, Milena Milovanovic, Philipp Simon, Marco Lorenz, Sandra Emily Stoll, Simon Dubler, Kristina Fuest, Francesk Mulita, Eumorifa Kondili, Ioannis Andrianopoulos, Iwan Meynaar, Alexander Daniel Cornet, Britt Sjøbøe, Anna Kluzik, Paweł Zatorski, Tomasz Drygalski, Wojciech Szczeklik, Joanna Solek-Pastuszka, Dariusz Onichimowski, Jan Stefaniak, Karina Stefanska-Wronka, Ewa Zabul, Filipe Sousa Cardoso, Maria José Arche Banzo, Teresa Maria Tomasa-Irriguible, Ángela Prado Mira, Susana Arias-Rivera, Fernando Frutos-Vivar, Sonia Lopez-Cuenca, Pablo Ruiz de Gopegui, Nour Abidi, Ivan Chau, Richard Pugh, Sara Smuts, and [missing] The COVIP-study group. 2022. “Health-Related Quality of Life in Older Patients Surviving ICU Treatment for COVID-19 : Results from an International Observational Study of Patients Older than 70 Years.” AGE AND AGEING 51 (2). doi:10.1093/ageing/afab278.
Vancouver
1.
Soliman IW, Leaver S, Flaatten H, Fjølner J, Wernly B, Bruno RR, et al. Health-related quality of life in older patients surviving ICU treatment for COVID-19 : results from an international observational study of patients older than 70 years. AGE AND AGEING. 2022;51(2).
IEEE
[1]
I. W. Soliman et al., “Health-related quality of life in older patients surviving ICU treatment for COVID-19 : results from an international observational study of patients older than 70 years,” AGE AND AGEING, vol. 51, no. 2, 2022.
@article{8741641,
  abstract     = {{Background health-related quality of life (HRQoL) is an important patient-centred outcome in patients surviving ICU admission for COVID-19. It is currently not clear which domains of the HRQoL are most affected. Objective to quantify HRQoL in order to identify areas of interventions. Design prospective observation study. Setting admissions to European ICUs between March 2020 and February 2021. Subjects patients aged 70 years or older admitted with COVID-19 disease. Methods collected determinants include SOFA-score, Clinical Frailty Scale (CFS), number and timing of ICU procedures and limitation of care, Katz Activities of Daily Living (ADL) dependence score. HRQoL was assessed at 3 months after ICU admission with the Euro-QoL-5D-5L questionnaire. An outcome of >= 4 on any of Euro-QoL-5D-5L domains was considered unfavourable. Results in total 3,140 patients from 14 European countries were included in this study. Three months after inclusion, 1,224 patients (39.0%) were alive and the EQ-5D-5L from was obtained. The CFS was associated with an increased odds ratio for an unfavourable HRQoL outcome after 3 months; OR 1.15 (95% confidence interval (CI): 0.71-1.87) for CFS 2 to OR 4.33 (95% CI: 1.57-11.9) for CFS >= 7. The Katz ADL was not statistically significantly associated with HRQoL after 3 months. Conclusions in critically ill old intensive care patients suffering from COVID-19, the CFS is associated with the subjectively perceived quality of life. The CFS on admission can be used to inform patients and relatives on the risk of an unfavourable qualitative outcome if such patients survive.}},
  articleno    = {{afab278}},
  author       = {{Soliman, Ivo W and Leaver, Susannah and Flaatten, Hans and Fjølner, Jesper and Wernly, Bernhard and Bruno, Raphael R and Artigas, Antonio and Bollen Pinto, Bernardo and Schefold, Joerg C and Beil, Michael and Sviri, Sigal and van Heerden, Peter Vernon and Szczeklik, Wojciech and Elhadi, Muhammed and Joannidis, Michael and Oeyen, Sandra and Zafeiridis, Tilemachos and Wollborn, Jakob and Banzo, Maria Jose Arche and Fuest, Kristina and Marsh, Brian and Andersen, Finn H and Moreno, Rui and Boumendil, Ariane and Guidet, Bertrand and Jung, Christian and De Lange, Dylan W and Eller, Philipp and Joannidis, Michael and Mesotten, Dieter and Reper, Pascal and Swinnen, Walter and Brix, Helene and Brushoej, Jens and Villefrance, Maja and Nedergaard, Helene Korvenius and Bjerregaard, Anders Thais and Balleby, Ida Riise and Andersen, Kasper and Hansen, Maria Aagaard and Uhrenholt, Stine and Bundgaard, Helle and Fjølner, Jesper and Mohamed, Aliae Ar Hussein and Salah, Rehab and Ali, Yasmin Khairy NasrEldin Mohamed and Wassim, Kyrillos and Elgazzar, Yumna A and Tharwat, Samar and Azzam, Ahmed Y and Habib, Ayman Abdelmawgoad and Abosheaishaa, Hazem Maarouf and Azab, Mohammed A and Leaver, Susannah and Galbois, Arnaud and Guidet, Bertrand and Charron, Cyril and Guerot, Emmanuel and Besch, Guillaume and Rigaud, Jean-Philippe and Maizel, Julien and Djibré, Michel and Burtin, Philippe and Garcon, Pierre and Nseir, Saad and Valette, Xavier and Alexandru, Nica and Marin, Nathalie and Vaissiere, Marie and Plantefeve, Gaëtan and Vanderlinden, Thierry and Jurcisin, Igor and Megarbane, Bruno and Caillard, Anais and Valent, Arnaud and Garnier, Marc and Besset, Sebastien and Oziel, Johanna and Raphaelen, Jean-Herlé and Dauger, Stéphane and Dumas, Guillaume and Goncalves, Bruno and Piton, Gaël and Jung, Christian and Bruno, Raphael Romano and Kelm, Malte and Wolff, Georg and Barth, Eberhard and Goebel, Ulrich and Barth, Eberhard and Kunstein, Anselm and Schuster, Michael and Welte, Martin and Lutz, Matthias and Meybohm, Patrick and Steiner, Stephan and Poerner, Tudor and Haake, Hendrik and Schaller, Stefan and Kindgen-Milles, Detlef and Meyer, Christian and Kurt, Muhammed and Kuhn, Karl Friedrich and Randerath, Winfried and Wollborn, Jakob and Dindane, Zouhir and Kabitz, Hans-Joachim and Voigt, Ingo and Shala, Gonxhe and Faltlhauser, Andreas and Rovina, Nikoletta and Aidoni, Zoi and Chrisanthopoulou, Evangelia and Papadogoulas, Antonios and Gurjar, Mohan and Mahmoodpoor, Ata and Ahmed, Abdullah Khudhur and Marsh, Brian and Elsaka, Ahmed and Sviri, Sigal and Comellini, Vittoria and Rabha, Ahmed and Ahmed, Hazem and Namendys-Silva, Silvio A and Ghannam, Abdelilah and Groenendijk, Martijn and Zegers, Marieke and de Lange, Dylan and Cornet, Alex and Evers, Mirjam and Haas, Lenneke and Dormans, Tom and Dieperink, Willem and Romundstad, Luis and Sjøbø, Britt and Andersen, Finn H and Strietzel, Hans Frank and Olasveengen, Theresa and Hahn, Michael and Czuczwar, Miroslaw and Gawda, Ryszard and Klimkiewicz, Jakub and de LurdesSantos, Maria Campos and Gordinho, André and Santos, Henrique and Assis, Rui and Oliveira, Ana Isabel Pinho and Badawy, Mohamed Raafat and Perez-Torres, David and Gomà, Gemma and Villamayor, Mercedes Ibarz and Mira, Angela Prado and Cubero, Patricia Jimeno and Rivera, Susana Arias and Tomasa, Teresa and Iglesias, David and Vázquez, Eric Mayor and Aldecoa, Cesar and Ferreira, Aida Fernández and Zalba-Etayo, Begoña and Canas-Perez, Isabel and Tamayo-Lomas, Luis and Diaz-Rodriguez, Cristina and Sancho, Susana and Priego, Jesús and Abualqumboz, Enas M Y and Hilles, Momin Majed Yousuf and Saleh, Mahmoud and Ben-HAmouda, Nawfel and Roberti, Andrea and Dullenkopf, Alexander and Fleury, Yvan and Pinto, Bernardo Bollen and Schefold, Joerg C and Al-Sadawi, Mohammed and Serck, Nicolas and Dewaele, Elisabeth and Kumar, Pritpal and Bundesen, Camilla and Innes, Richard and Gooch, James and Cagova, Lenka and Potter, Elizabeth and Reay, Michael and Davey, Miriam and Humphreys, Sally and Berlemont, Caroline Hauw and Chousterman, Benjamin Glenn and Dépret, François and Ferre, Alexis and Vettoretti, Lucie and Thevenin, Didier and Faltlhauser, Andreas and Milovanovic, Milena and Simon, Philipp and Lorenz, Marco and Stoll, Sandra Emily and Dubler, Simon and Fuest, Kristina and Mulita, Francesk and Kondili, Eumorifa and Andrianopoulos, Ioannis and Meynaar, Iwan and Cornet, Alexander Daniel and Sjøbøe, Britt and Kluzik, Anna and Zatorski, Paweł and Drygalski, Tomasz and Szczeklik, Wojciech and Solek-Pastuszka, Joanna and Onichimowski, Dariusz and Stefaniak, Jan and Stefanska-Wronka, Karina and Zabul, Ewa and Cardoso, Filipe Sousa and Banzo, Maria José Arche and Tomasa-Irriguible, Teresa Maria and Mira, Ángela Prado and Arias-Rivera, Susana and Frutos-Vivar, Fernando and Lopez-Cuenca, Sonia and de Gopegui, Pablo Ruiz and Abidi, Nour and Chau, Ivan and Pugh, Richard and Smuts, Sara and The COVIP-study group, [missing]}},
  issn         = {{0002-0729}},
  journal      = {{AGE AND AGEING}},
  keywords     = {{Geriatrics and Gerontology,Aging,General Medicine,Intensive Care Unit (ICU),frailty,Quality of Life,Survival,Older people,COVID-19,INTENSIVE-CARE,SOCIETY}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{10}},
  title        = {{Health-related quality of life in older patients surviving ICU treatment for COVID-19 : results from an international observational study of patients older than 70 years}},
  url          = {{http://doi.org/10.1093/ageing/afab278}},
  volume       = {{51}},
  year         = {{2022}},
}

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