Molecular correlates of hypothalamic development in songbird ontogeny in comparison with the telencephalon
- Author
- Gaurav Majumdar, Garima Yadav, Julie Hamaide, Louis Coussement (UGent) , Tim De Meyer (UGent) , Marleen Verhoye, Wim Vanden Berghe, Annemie Van der Linden and Jacques Balthazart
- Organization
- Abstract
- Development of the songbird brain provides an excellent experimental model for understanding the regulation of sex differences in ontogeny. Considering the regulatory role of the hypothalamus in endocrine, in particular reproductive, physiology, we measured the structural (volume) and molecular correlates of hypothalamic development during ontogeny of male and female zebra finches. We quantified by relative quantitative polymerase chain reaction (rqPCR) the expression of 14 genes related to thyroid and steroid hormones actions as well as 12 genes related to brain plasticity at four specific time points during ontogeny and compared these expression patterns with the expression of the same genes as detected by transcriptomics in the telencephalon. These two different methodological approaches detected specific changes with age and demonstrated that in a substantial number of cases changes observed in both brain regions are nearly identical. Other genes however had a tissue-specific developmental pattern. Sex differences or interactions of sex by age were detected in the expression of a subset of genes, more in hypothalamus than telencephalon. These results correlate with multiple known aspects of the developmental and reproductive physiology but also raise a number of new functional questions.
- Keywords
- hormones, hypothalamus, ontogeny, sexual dimorphism, telencephalon, zebra finch, TESTOSTERONE-METABOLIZING ENZYMES, RECEPTOR MESSENGER-RNA, FEMALE ZEBRA FINCHES, SEXUAL-DIFFERENTIATION, THYROID-HORMONE, GENE-EXPRESSION, BRAIN NUCLEI, AROMATASE, BEHAVIOR, ORGANIZATION
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8741115
- MLA
- Majumdar, Gaurav, et al. “Molecular Correlates of Hypothalamic Development in Songbird Ontogeny in Comparison with the Telencephalon.” FASEB JOURNAL, vol. 34, no. 4, 2020, pp. 4997–5015, doi:10.1096/fj.201902477R.
- APA
- Majumdar, G., Yadav, G., Hamaide, J., Coussement, L., De Meyer, T., Verhoye, M., … Balthazart, J. (2020). Molecular correlates of hypothalamic development in songbird ontogeny in comparison with the telencephalon. FASEB JOURNAL, 34(4), 4997–5015. https://doi.org/10.1096/fj.201902477R
- Chicago author-date
- Majumdar, Gaurav, Garima Yadav, Julie Hamaide, Louis Coussement, Tim De Meyer, Marleen Verhoye, Wim Vanden Berghe, Annemie Van der Linden, and Jacques Balthazart. 2020. “Molecular Correlates of Hypothalamic Development in Songbird Ontogeny in Comparison with the Telencephalon.” FASEB JOURNAL 34 (4): 4997–5015. https://doi.org/10.1096/fj.201902477R.
- Chicago author-date (all authors)
- Majumdar, Gaurav, Garima Yadav, Julie Hamaide, Louis Coussement, Tim De Meyer, Marleen Verhoye, Wim Vanden Berghe, Annemie Van der Linden, and Jacques Balthazart. 2020. “Molecular Correlates of Hypothalamic Development in Songbird Ontogeny in Comparison with the Telencephalon.” FASEB JOURNAL 34 (4): 4997–5015. doi:10.1096/fj.201902477R.
- Vancouver
- 1.Majumdar G, Yadav G, Hamaide J, Coussement L, De Meyer T, Verhoye M, et al. Molecular correlates of hypothalamic development in songbird ontogeny in comparison with the telencephalon. FASEB JOURNAL. 2020;34(4):4997–5015.
- IEEE
- [1]G. Majumdar et al., “Molecular correlates of hypothalamic development in songbird ontogeny in comparison with the telencephalon,” FASEB JOURNAL, vol. 34, no. 4, pp. 4997–5015, 2020.
@article{8741115,
abstract = {{Development of the songbird brain provides an excellent experimental model for understanding the regulation of sex differences in ontogeny. Considering the regulatory role of the hypothalamus in endocrine, in particular reproductive, physiology, we measured the structural (volume) and molecular correlates of hypothalamic development during ontogeny of male and female zebra finches. We quantified by relative quantitative polymerase chain reaction (rqPCR) the expression of 14 genes related to thyroid and steroid hormones actions as well as 12 genes related to brain plasticity at four specific time points during ontogeny and compared these expression patterns with the expression of the same genes as detected by transcriptomics in the telencephalon. These two different methodological approaches detected specific changes with age and demonstrated that in a substantial number of cases changes observed in both brain regions are nearly identical. Other genes however had a tissue-specific developmental pattern. Sex differences or interactions of sex by age were detected in the expression of a subset of genes, more in hypothalamus than telencephalon. These results correlate with multiple known aspects of the developmental and reproductive physiology but also raise a number of new functional questions.}},
author = {{Majumdar, Gaurav and Yadav, Garima and Hamaide, Julie and Coussement, Louis and De Meyer, Tim and Verhoye, Marleen and Vanden Berghe, Wim and Van der Linden, Annemie and Balthazart, Jacques}},
issn = {{0892-6638}},
journal = {{FASEB JOURNAL}},
keywords = {{hormones,hypothalamus,ontogeny,sexual dimorphism,telencephalon,zebra finch,TESTOSTERONE-METABOLIZING ENZYMES,RECEPTOR MESSENGER-RNA,FEMALE ZEBRA FINCHES,SEXUAL-DIFFERENTIATION,THYROID-HORMONE,GENE-EXPRESSION,BRAIN NUCLEI,AROMATASE,BEHAVIOR,ORGANIZATION}},
language = {{eng}},
number = {{4}},
pages = {{4997--5015}},
title = {{Molecular correlates of hypothalamic development in songbird ontogeny in comparison with the telencephalon}},
url = {{http://doi.org/10.1096/fj.201902477R}},
volume = {{34}},
year = {{2020}},
}
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