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Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients : prospective observational study in European intensive care units

Kamil Polok, Jakub Fronczek, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjølner, Susannah Leaver, Michael Beil, Sigal Sviri, et al.
(2022) BRITISH JOURNAL OF ANAESTHESIA. 128(3). p.482-490
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Abstract
Background: Tracheostomy is performed in patients expected to require prolonged mechanical ventilation, but to date optimal timing of tracheostomy has not been established. The evidence concerning tracheostomy in COVID-19 patients is particularly scarce. We aimed to describe the relationship between early tracheostomy (<= 10 days since intubation) and outcomes for patients with COVID-19. Methods: This was a prospective cohort study performed in 152 centres across 16 European countries from February to December 2020. We included patients aged >= 70 yr with confirmed COVID-19 infection admitted to an intensive care unit, requiring invasive mechanical ventilation. Multivariable analyses were performed to evaluate the association between early tracheostomy and clinical outcomes including 3-month mortality, intensive care length of stay, and duration of mechanical ventilation. Results: The final analysis included 1740 patients with a mean age of 74 yr. Tracheostomy was performed in 461 (26.5%) patients. The tracheostomy rate varied across countries, from 8.3% to 52.9%. Early tracheostomy was performed in 135 (29.3%) patients. There was no difference in 3-month mortality between early and late tracheostomy in either our primary analysis (hazard ratio [HR]=0.96; 95% confidence interval [CI], 0.70-1.33) or a secondary landmark analysis (HR=0.78; 95% CI, 0.57-1.06). Conclusions: There is a wide variation across Europe in the timing of tracheostomy for critically ill patients with COVID-19. However, we found no evidence that early tracheostomy is associated with any effect on survival amongst older critically ill patients with COVID-19.
Keywords
Anesthesiology and Pain Medicine, COVID-19, healthcare, intensive care units, mechanical ventilation, outcome assessment, tracheostomy

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MLA
Polok, Kamil, et al. “Association between Tracheostomy Timing and Outcomes for Older Critically Ill COVID-19 Patients : Prospective Observational Study in European Intensive Care Units.” BRITISH JOURNAL OF ANAESTHESIA, vol. 128, no. 3, 2022, pp. 482–90, doi:10.1016/j.bja.2021.11.027.
APA
Polok, K., Fronczek, J., van Heerden, P. V., Flaatten, H., Guidet, B., De Lange, D. W., … Szczeklik, W. (2022). Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients : prospective observational study in European intensive care units. BRITISH JOURNAL OF ANAESTHESIA, 128(3), 482–490. https://doi.org/10.1016/j.bja.2021.11.027
Chicago author-date
Polok, Kamil, Jakub Fronczek, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjølner, et al. 2022. “Association between Tracheostomy Timing and Outcomes for Older Critically Ill COVID-19 Patients : Prospective Observational Study in European Intensive Care Units.” BRITISH JOURNAL OF ANAESTHESIA 128 (3): 482–90. https://doi.org/10.1016/j.bja.2021.11.027.
Chicago author-date (all authors)
Polok, Kamil, Jakub Fronczek, Peter Vernon van Heerden, Hans Flaatten, Bertrand Guidet, Dylan W. De Lange, Jesper Fjølner, Susannah Leaver, Michael Beil, Sigal Sviri, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Dorota Studzińska, Michael Joannidis, Sandra Oeyen, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Christian Jung, and Wojciech Szczeklik. 2022. “Association between Tracheostomy Timing and Outcomes for Older Critically Ill COVID-19 Patients : Prospective Observational Study in European Intensive Care Units.” BRITISH JOURNAL OF ANAESTHESIA 128 (3): 482–490. doi:10.1016/j.bja.2021.11.027.
Vancouver
1.
Polok K, Fronczek J, van Heerden PV, Flaatten H, Guidet B, De Lange DW, et al. Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients : prospective observational study in European intensive care units. BRITISH JOURNAL OF ANAESTHESIA. 2022;128(3):482–90.
IEEE
[1]
K. Polok et al., “Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients : prospective observational study in European intensive care units,” BRITISH JOURNAL OF ANAESTHESIA, vol. 128, no. 3, pp. 482–490, 2022.
@article{8739891,
  abstract     = {{Background: Tracheostomy is performed in patients expected to require prolonged mechanical ventilation, but to date optimal timing of tracheostomy has not been established. The evidence concerning tracheostomy in COVID-19 patients is particularly scarce. We aimed to describe the relationship between early tracheostomy (<= 10 days since intubation) and outcomes for patients with COVID-19.

Methods: This was a prospective cohort study performed in 152 centres across 16 European countries from February to December 2020. We included patients aged >= 70 yr with confirmed COVID-19 infection admitted to an intensive care unit, requiring invasive mechanical ventilation. Multivariable analyses were performed to evaluate the association between early tracheostomy and clinical outcomes including 3-month mortality, intensive care length of stay, and duration of mechanical ventilation.

Results: The final analysis included 1740 patients with a mean age of 74 yr. Tracheostomy was performed in 461 (26.5%) patients. The tracheostomy rate varied across countries, from 8.3% to 52.9%. Early tracheostomy was performed in 135 (29.3%) patients. There was no difference in 3-month mortality between early and late tracheostomy in either our primary analysis (hazard ratio [HR]=0.96; 95% confidence interval [CI], 0.70-1.33) or a secondary landmark analysis (HR=0.78; 95% CI, 0.57-1.06).

Conclusions: There is a wide variation across Europe in the timing of tracheostomy for critically ill patients with COVID-19. However, we found no evidence that early tracheostomy is associated with any effect on survival amongst older critically ill patients with COVID-19.}},
  author       = {{Polok, Kamil and Fronczek, Jakub and van Heerden, Peter Vernon and Flaatten, Hans and Guidet, Bertrand and De Lange, Dylan W. and Fjølner, Jesper and Leaver, Susannah and Beil, Michael and Sviri, Sigal and Bruno, Raphael Romano and Wernly, Bernhard and Artigas, Antonio and Pinto, Bernardo Bollen and Schefold, Joerg C. and Studzińska, Dorota and Joannidis, Michael and Oeyen, Sandra and Marsh, Brian and Andersen, Finn H. and Moreno, Rui and Cecconi, Maurizio and Jung, Christian and Szczeklik, Wojciech}},
  issn         = {{0007-0912}},
  journal      = {{BRITISH JOURNAL OF ANAESTHESIA}},
  keywords     = {{Anesthesiology and Pain Medicine,COVID-19,healthcare,intensive care units,mechanical ventilation,outcome assessment,tracheostomy}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{482--490}},
  title        = {{Association between tracheostomy timing and outcomes for older critically ill COVID-19 patients : prospective observational study in European intensive care units}},
  url          = {{http://doi.org/10.1016/j.bja.2021.11.027}},
  volume       = {{128}},
  year         = {{2022}},
}
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