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Shear wave elastography of lymph nodes in dogs with head and neck cancer : a pilot study

Sophie Favril (UGent) , Emmelie Stock (UGent) , Bart Broeckx (UGent) , Nausikaa Devriendt (UGent) , Hilde De Rooster (UGent) and Katrien Vanderperren (UGent)
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Abstract
Shear wave elastography (SWE) is a novel ultrasound imaging technique, used in human medicine to differentiate metastatic from non-metastatic lymph nodes (LNs) based on higher tissue stiffness. The objective of this pilot study was to evaluate whether canine metastatic LNs were stiffer compared to non-metastatic LNs. SWE of sentinel or regional LNs in dogs with head and neck cancer was performed. Ten elastograms of each LN were acquired. In each elastogram, mean, median, and maximum shear wave velocities (SWVs) were calculated in the most elastic region, the stiffest region, and the entire LN. The means of those SWVs for each region of each LN were subsequently calculated. Furthermore, a stepwise subsampling was performed to assess the effect of the number of acquired elastograms on the consistency of the classification of a LN as metastatic or not. Twenty-four LNs in 15 dogs with head and neck cancer were included, of which 10 LNs were metastatic. Metastatic medial retropharyngeal and mandibular LNs were successfully distinguished from non-metastatic LNs based on higher mean and median SWVs in the stiffest region and higher maximum SWVs in entire LNs. Furthermore, maximum SWVs in the stiffest region of mandibular LNs were higher in metastatic LNs compared to non-metastatic LNs. Downstream analyses demonstrated that at least eight elastograms were necessary to perform reliable analyses. This pilot trial demonstrated that SWE has potential to discriminate metastatic from non-metastatic LNs; however, LN status should be based on at least eight elastograms in future clinical trials.
Keywords
General Veterinary, dogs, lymph node, metastases, shear wave elastography, ultrasound, MAST-CELL TUMORS, METASTASIS, CANINE, LIVER

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Citation

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MLA
Favril, Sophie, et al. “Shear Wave Elastography of Lymph Nodes in Dogs with Head and Neck Cancer : A Pilot Study.” VETERINARY AND COMPARATIVE ONCOLOGY, vol. 20, no. 2, 2022, pp. 521–28, doi:10.1111/vco.12803.
APA
Favril, S., Stock, E., Broeckx, B., Devriendt, N., De Rooster, H., & Vanderperren, K. (2022). Shear wave elastography of lymph nodes in dogs with head and neck cancer : a pilot study. VETERINARY AND COMPARATIVE ONCOLOGY, 20(2), 521–528. https://doi.org/10.1111/vco.12803
Chicago author-date
Favril, Sophie, Emmelie Stock, Bart Broeckx, Nausikaa Devriendt, Hilde De Rooster, and Katrien Vanderperren. 2022. “Shear Wave Elastography of Lymph Nodes in Dogs with Head and Neck Cancer : A Pilot Study.” VETERINARY AND COMPARATIVE ONCOLOGY 20 (2): 521–28. https://doi.org/10.1111/vco.12803.
Chicago author-date (all authors)
Favril, Sophie, Emmelie Stock, Bart Broeckx, Nausikaa Devriendt, Hilde De Rooster, and Katrien Vanderperren. 2022. “Shear Wave Elastography of Lymph Nodes in Dogs with Head and Neck Cancer : A Pilot Study.” VETERINARY AND COMPARATIVE ONCOLOGY 20 (2): 521–528. doi:10.1111/vco.12803.
Vancouver
1.
Favril S, Stock E, Broeckx B, Devriendt N, De Rooster H, Vanderperren K. Shear wave elastography of lymph nodes in dogs with head and neck cancer : a pilot study. VETERINARY AND COMPARATIVE ONCOLOGY. 2022;20(2):521–8.
IEEE
[1]
S. Favril, E. Stock, B. Broeckx, N. Devriendt, H. De Rooster, and K. Vanderperren, “Shear wave elastography of lymph nodes in dogs with head and neck cancer : a pilot study,” VETERINARY AND COMPARATIVE ONCOLOGY, vol. 20, no. 2, pp. 521–528, 2022.
@article{8738181,
  abstract     = {{Shear wave elastography (SWE) is a novel ultrasound imaging technique, used in human medicine to differentiate metastatic from non-metastatic lymph nodes (LNs) based on higher tissue stiffness. The objective of this pilot study was to evaluate whether canine metastatic LNs were stiffer compared to non-metastatic LNs. SWE of sentinel or regional LNs in dogs with head and neck cancer was performed. Ten elastograms of each LN were acquired. In each elastogram, mean, median, and maximum shear wave velocities (SWVs) were calculated in the most elastic region, the stiffest region, and the entire LN. The means of those SWVs for each region of each LN were subsequently calculated. Furthermore, a stepwise subsampling was performed to assess the effect of the number of acquired elastograms on the consistency of the classification of a LN as metastatic or not. Twenty-four LNs in 15 dogs with head and neck cancer were included, of which 10 LNs were metastatic. Metastatic medial retropharyngeal and mandibular LNs were successfully distinguished from non-metastatic LNs based on higher mean and median SWVs in the stiffest region and higher maximum SWVs in entire LNs. Furthermore, maximum SWVs in the stiffest region of mandibular LNs were higher in metastatic LNs compared to non-metastatic LNs. Downstream analyses demonstrated that at least eight elastograms were necessary to perform reliable analyses. This pilot trial demonstrated that SWE has potential to discriminate metastatic from non-metastatic LNs; however, LN status should be based on at least eight elastograms in future clinical trials.}},
  author       = {{Favril, Sophie and Stock, Emmelie and Broeckx, Bart and Devriendt, Nausikaa and De Rooster, Hilde and Vanderperren, Katrien}},
  issn         = {{1476-5810}},
  journal      = {{VETERINARY AND COMPARATIVE ONCOLOGY}},
  keywords     = {{General Veterinary,dogs,lymph node,metastases,shear wave elastography,ultrasound,MAST-CELL TUMORS,METASTASIS,CANINE,LIVER}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{521--528}},
  title        = {{Shear wave elastography of lymph nodes in dogs with head and neck cancer : a pilot study}},
  url          = {{http://dx.doi.org/10.1111/vco.12803}},
  volume       = {{20}},
  year         = {{2022}},
}

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