@article{8737775,
  abstract     = {{Oxidative/carbonyl stress is elevated in lower-limb muscles of patients with chronic obstructive pulmonary disease (COPD). Carnosine is a skeletal muscle antioxidant particularly present in fast-twitch fibers. The aims of the present study were to compare muscle carnosine, oxidative/carbonyl stress, antioxidants, and fiber characteristics between patients with COPD and healthy controls (HCs) and between patients after stratification for airflow limitation (mild/moderate vs. severe/very severe), as well as to investigate correlates of carnosine in patients with COPD. A vastus lateralis muscle biopsy was obtained from 40 patients with stable COPD and 20 age- and sex-matched HCs. Carnosine, oxidative/carbonyl stress, antioxidants, fiber characteristics, quadriceps strength and endurance (QE), V̇o2peak (incremental cycle test), and physical activity (PA) were determined. Patients with COPD had a similar carnosine concentration [4.16 mmol/kg wet weight (WW; SD = 1.93)] to HCs [4.64 mmol/kg WW (SD = 1.71)] and significantly higher percentage of fast-twitch fibers and lower QE, V̇o2peak, and PA versus HCs. Patients with severe/very severe COPD had a 31% lower carnosine concentration [3.24 mmol/kg WW (SD = 1.79); n = 15] versus patients with mild/moderate COPD [4.71 mmol/kg WW (SD = 1.83); n = 25; P = 0.02] and significantly lower V̇o2peak and PA versus patients with mild/moderate COPD. Carnosine correlated significantly with QE (rs = 0.427), V̇o2peak (rs = 0.334), PA (rs = 0.379), and lung function parameters in patients with COPD. In conclusion, despite having the highest proportion of fast-twitch fibers, patients with severe/very severe COPD displayed a 31% lower muscle carnosine concentration compared with patients with mild/moderate COPD. As no other markers of oxidative/carbonyl stress or antioxidants were affected, the observed carnosine deficiency is thought to be a possible first sign of muscle redox balance abnormalities.NEW & NOTEWORTHY Carnosine, particularly present in fast-twitch fibers, was investigated in the quadriceps of patients with chronic obstructive pulmonary disease (COPD). Carnosine concentration was similar between patients with COPD and healthy controls but was 31% lower in patients with severe/very severe COPD, despite their high proportion of fast-twitch fibers, versus patients with mild/moderate COPD. As no other markers of oxidative/carbonyl stress or antioxidants were affected, the observed carnosine deficiency is thought to be a possible first sign of muscle redox balance abnormalities.}},
  author       = {{De Brandt, Jana and Burtin, C. and Pomiès, P. and Vandenabeele, F. and Verboven, K. and Aumann, J. and Blancquaert, Laura and Everaert, Inge and Van Ryckeghem, L. and Cops, J. and Hayot, M. and Spruit, M. A. and Derave, Wim}},
  issn         = {{8750-7587}},
  journal      = {{JOURNAL OF APPLIED PHYSIOLOGY}},
  keywords     = {{Physiology (medical),Physiology,carbonyl stress,carnosine,chronic obstructive pulmonary disease,oxidative stress,quadriceps,VASTUS LATERALIS MUSCLE,SKELETAL-MUSCLE,PROTEIN OXIDATION,PULMONARY,EXERCISE,SUPPLEMENTATION,DYSFUNCTION,MORTALITY,ENDURANCE,MODERATE}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1230--1240}},
  title        = {{Carnosine, oxidative and carbonyl stress, antioxidants, and muscle fiber characteristics of quadriceps muscle of patients with COPD}},
  url          = {{http://dx.doi.org/10.1152/japplphysiol.00200.2021}},
  volume       = {{131}},
  year         = {{2021}},
}

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