Analytical characterization of 'etonitazepyne', a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online
- Author
- Peter Blanckaert, Margot Balcaen, Céline Vanhee, Martijn Risseeuw (UGent) , Michaël Canfyn, Bart Desmedt, Serge Van Calenbergh (UGent) and Eric Deconinck
- Organization
- Abstract
- This paper reports on the identification and full chemical characterization of the substance colloquially called "etonitazepyne" or "N-pyrrolidino etonitazene" (2-(4-ethoxybenzyl)-5-nitro-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazole), a potent NPS opioid of the 5-nitrobenzimidazole class. Identification of etonitazepyne was performed, on a sample purchased during routine monitoring of the drug market, using GC-MS, HRAM LC-MS/MS, H-1 NMR, and FTIR. The chromatographic data, together with the FTIR data, indicated the presence of a highly pure compound and already indicated a benzimidazole structure. The specific benzimidazole regio-isomer was confirmed using H-1 NMR spectroscopy, resulting in the unambiguous identification of etonitazepyne.
- Keywords
- Spectroscopy, Pharmaceutical Science, Environmental Chemistry, Analytical Chemistry, benzimidazoles, etonitazene, new psychoactive substances, opioid NPS, pyrrolidine analogue, UND VERWANDTE HETEROCYCLEN, SUBSTANCES
Downloads
-
(...).pdf
- full text (Published version)
- |
- UGent only
- |
- |
- 7.82 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8737722
- MLA
- Blanckaert, Peter, et al. “Analytical Characterization of ‘Etonitazepyne’, a New Pyrrolidinyl‐containing 2‐benzylbenzimidazole Opioid Sold Online.” DRUG TESTING AND ANALYSIS, vol. 13, no. 9, 2021, pp. 1627–34, doi:10.1002/dta.3113.
- APA
- Blanckaert, P., Balcaen, M., Vanhee, C., Risseeuw, M., Canfyn, M., Desmedt, B., … Deconinck, E. (2021). Analytical characterization of “etonitazepyne”, a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online. DRUG TESTING AND ANALYSIS, 13(9), 1627–1634. https://doi.org/10.1002/dta.3113
- Chicago author-date
- Blanckaert, Peter, Margot Balcaen, Céline Vanhee, Martijn Risseeuw, Michaël Canfyn, Bart Desmedt, Serge Van Calenbergh, and Eric Deconinck. 2021. “Analytical Characterization of ‘Etonitazepyne’, a New Pyrrolidinyl‐containing 2‐benzylbenzimidazole Opioid Sold Online.” DRUG TESTING AND ANALYSIS 13 (9): 1627–34. https://doi.org/10.1002/dta.3113.
- Chicago author-date (all authors)
- Blanckaert, Peter, Margot Balcaen, Céline Vanhee, Martijn Risseeuw, Michaël Canfyn, Bart Desmedt, Serge Van Calenbergh, and Eric Deconinck. 2021. “Analytical Characterization of ‘Etonitazepyne’, a New Pyrrolidinyl‐containing 2‐benzylbenzimidazole Opioid Sold Online.” DRUG TESTING AND ANALYSIS 13 (9): 1627–1634. doi:10.1002/dta.3113.
- Vancouver
- 1.Blanckaert P, Balcaen M, Vanhee C, Risseeuw M, Canfyn M, Desmedt B, et al. Analytical characterization of “etonitazepyne”, a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online. DRUG TESTING AND ANALYSIS. 2021;13(9):1627–34.
- IEEE
- [1]P. Blanckaert et al., “Analytical characterization of ‘etonitazepyne’, a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online,” DRUG TESTING AND ANALYSIS, vol. 13, no. 9, pp. 1627–1634, 2021.
@article{8737722,
abstract = {{This paper reports on the identification and full chemical characterization of the substance colloquially called "etonitazepyne" or "N-pyrrolidino etonitazene" (2-(4-ethoxybenzyl)-5-nitro-1-(2-(pyrrolidin-1-yl)ethyl)-1H-benzo[d]imidazole), a potent NPS opioid of the 5-nitrobenzimidazole class. Identification of etonitazepyne was performed, on a sample purchased during routine monitoring of the drug market, using GC-MS, HRAM LC-MS/MS, H-1 NMR, and FTIR. The chromatographic data, together with the FTIR data, indicated the presence of a highly pure compound and already indicated a benzimidazole structure. The specific benzimidazole regio-isomer was confirmed using H-1 NMR spectroscopy, resulting in the unambiguous identification of etonitazepyne.}},
author = {{Blanckaert, Peter and Balcaen, Margot and Vanhee, Céline and Risseeuw, Martijn and Canfyn, Michaël and Desmedt, Bart and Van Calenbergh, Serge and Deconinck, Eric}},
issn = {{1942-7603}},
journal = {{DRUG TESTING AND ANALYSIS}},
keywords = {{Spectroscopy,Pharmaceutical Science,Environmental Chemistry,Analytical Chemistry,benzimidazoles,etonitazene,new psychoactive substances,opioid NPS,pyrrolidine analogue,UND VERWANDTE HETEROCYCLEN,SUBSTANCES}},
language = {{eng}},
number = {{9}},
pages = {{1627--1634}},
title = {{Analytical characterization of 'etonitazepyne', a new pyrrolidinyl‐containing 2‐benzylbenzimidazole opioid sold online}},
url = {{http://doi.org/10.1002/dta.3113}},
volume = {{13}},
year = {{2021}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: