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Oral administration of β-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM

Edith Stuyven UGent, F Verdonck, Ingrid van Hoek UGent, Sylvie Daminet UGent, Luc Duchateau UGent, Jean Paul Remon UGent, Bruno Goddeeris UGent and Eric Cox UGent (2010) CLINICAL AND VACCINE IMMUNOLOGY. 17(2). p.281-285
abstract
The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.
Please use this url to cite or link to this publication:
author
organization
alternative title
Oral administration of beta-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM
year
type
journalArticle (original)
publication status
published
subject
keyword
INFECTION, ADJUVANT, IMMUNOGLOBULIN-A, BETA-GLUCAN RECEPTOR, IMMUNE-RESPONSE, IN-VIVO, DECTIN-1, YEAST, RESISTANCE, MACROPHAGES
journal title
CLINICAL AND VACCINE IMMUNOLOGY
Clin. Vaccine Immunol.
volume
17
issue
2
pages
5 pages
Web of Science type
Article
Web of Science id
000274085200012
JCR category
MICROBIOLOGY
JCR impact factor
2.471 (2010)
JCR rank
48/103 (2010)
JCR quartile
2 (2010)
ISSN
1556-6811
DOI
10.1128/CVI.00344-09
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
873724
handle
http://hdl.handle.net/1854/LU-873724
date created
2010-02-22 15:16:03
date last changed
2010-03-29 15:03:03
@article{873724,
  abstract     = {The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.},
  author       = {Stuyven, Edith and Verdonck, F and van Hoek, Ingrid and Daminet, Sylvie and Duchateau, Luc and Remon, Jean Paul and Goddeeris, Bruno and Cox, Eric},
  issn         = {1556-6811},
  journal      = {CLINICAL AND VACCINE IMMUNOLOGY},
  keyword      = {INFECTION,ADJUVANT,IMMUNOGLOBULIN-A,BETA-GLUCAN RECEPTOR,IMMUNE-RESPONSE,IN-VIVO,DECTIN-1,YEAST,RESISTANCE,MACROPHAGES},
  language     = {eng},
  number       = {2},
  pages        = {281--285},
  title        = {Oral administration of \ensuremath{\beta}-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM},
  url          = {http://dx.doi.org/10.1128/CVI.00344-09},
  volume       = {17},
  year         = {2010},
}

Chicago
Stuyven, Edith, F Verdonck, Ingrid van Hoek, Sylvie Daminet, Luc Duchateau, Jean Paul Remon, Bruno Goddeeris, and Eric Cox. 2010. “Oral Administration of Β-1,3/1,6-glucan to Dogs Temporally Changes Total and Antigen-specific IgA and IgM.” Clinical and Vaccine Immunology 17 (2): 281–285.
APA
Stuyven, Edith, Verdonck, F., van Hoek, I., Daminet, S., Duchateau, L., Remon, J. P., Goddeeris, B., et al. (2010). Oral administration of β-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM. CLINICAL AND VACCINE IMMUNOLOGY, 17(2), 281–285.
Vancouver
1.
Stuyven E, Verdonck F, van Hoek I, Daminet S, Duchateau L, Remon JP, et al. Oral administration of β-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM. CLINICAL AND VACCINE IMMUNOLOGY. 2010;17(2):281–5.
MLA
Stuyven, Edith, F Verdonck, Ingrid van Hoek, et al. “Oral Administration of Β-1,3/1,6-glucan to Dogs Temporally Changes Total and Antigen-specific IgA and IgM.” CLINICAL AND VACCINE IMMUNOLOGY 17.2 (2010): 281–285. Print.