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Oral administration of β-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM

Edith Stuyven (UGent) , F Verdonck, Ingrid van Hoek (UGent) , Sylvie Daminet (UGent) , Luc Duchateau (UGent) , Jean Paul Remon (UGent) , Bruno Goddeeris (UGent) and Eric Cox (UGent)
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Abstract
The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.
Keywords
INFECTION, ADJUVANT, IMMUNOGLOBULIN-A, BETA-GLUCAN RECEPTOR, IMMUNE-RESPONSE, IN-VIVO, DECTIN-1, YEAST, RESISTANCE, MACROPHAGES

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Chicago
Stuyven, Edith, F Verdonck, Ingrid van Hoek, Sylvie Daminet, Luc Duchateau, Jean Paul Remon, Bruno Goddeeris, and Eric Cox. 2010. “Oral Administration of Β-1,3/1,6-glucan to Dogs Temporally Changes Total and Antigen-specific IgA and IgM.” Clinical and Vaccine Immunology 17 (2): 281–285.
APA
Stuyven, Edith, Verdonck, F., van Hoek, I., Daminet, S., Duchateau, L., Remon, J. P., Goddeeris, B., et al. (2010). Oral administration of β-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM. CLINICAL AND VACCINE IMMUNOLOGY, 17(2), 281–285.
Vancouver
1.
Stuyven E, Verdonck F, van Hoek I, Daminet S, Duchateau L, Remon JP, et al. Oral administration of β-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM. CLINICAL AND VACCINE IMMUNOLOGY. 2010;17(2):281–5.
MLA
Stuyven, Edith, F Verdonck, Ingrid van Hoek, et al. “Oral Administration of Β-1,3/1,6-glucan to Dogs Temporally Changes Total and Antigen-specific IgA and IgM.” CLINICAL AND VACCINE IMMUNOLOGY 17.2 (2010): 281–285. Print.
@article{873724,
  abstract     = {The effect of oral administration of beta-1,3/1,6-glucans from Saccharomyces cerevisiae on humoral immunity in domestic dogs is not known. In this study, 15 beagle dogs were orally given MacroGard tablets, which contain 150 mg of this beta-glucan, daily for 4 weeks. At the end of this period, the total serum immunoglobulin A (IgA) level decreased significantly in the group treated with the glucan compared to that in the control group as well as compared to the concentrations before supplementation. In contrast, the total serum IgM level rose significantly, whereas no effect on the IgG level occurred. Similar changes were seen in Bordetella-specific IgA and IgM titers following vaccination during the supplementation period. The IgA concentration also became significantly lower in the saliva and tears of the glucan group than in the placebo group. The effects disappeared 1 week after the cessation of the supplementation. In conclusion, the results showed a temporary change in the isotype profile during glucan supplementation.},
  author       = {Stuyven, Edith and Verdonck, F and van Hoek, Ingrid and Daminet, Sylvie and Duchateau, Luc and Remon, Jean Paul and Goddeeris, Bruno and Cox, Eric},
  issn         = {1556-6811},
  journal      = {CLINICAL AND VACCINE IMMUNOLOGY},
  keyword      = {INFECTION,ADJUVANT,IMMUNOGLOBULIN-A,BETA-GLUCAN RECEPTOR,IMMUNE-RESPONSE,IN-VIVO,DECTIN-1,YEAST,RESISTANCE,MACROPHAGES},
  language     = {eng},
  number       = {2},
  pages        = {281--285},
  title        = {Oral administration of \ensuremath{\beta}-1,3/1,6-glucan to dogs temporally changes total and antigen-specific IgA and IgM},
  url          = {http://dx.doi.org/10.1128/CVI.00344-09},
  volume       = {17},
  year         = {2010},
}

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