Photo‐crosslinked gelatin‐based hydrogel films to support wound healing
- Author
- Birgit Stubbe, Arn Mignon (UGent) , Lana Van Damme (UGent) , Karel Claes (UGent) , Henk Hoeksema, Stan Monstrey (UGent) , Sandra Van Vlierberghe (UGent) and Peter Dubruel (UGent)
- Organization
- Project
-
- Exploiting polymersomes to create 'smart' wound dressings with diagnostic and antimicrobial capabilities
- Design of solid-state crosslinkable gelatins for biomedical applications
- Development of Polymer-Based Systems for Wound treatment
- Co-extrusion electrospinning as novel tool for the next generation wound dressings: taking ultimate control over the dressing mechanical and release properties.
- Abstract
- Gelatin is used widely in the biomedical field, among other for wound healing. Given its upper critical solution temperature, crosslinking is required. To this end, gelatin is chemically modified with different photo-crosslinkable moieties with low (32-34%) and high (63-65%) degree of substitution (DS): gelatin-methacrylamide (gel-MA) and gelatin-acrylamide (gel-AA) and gelatin-pentenamide (gel-PE). Next to the more researched gel-MA, it is especially interesting and novel to compare with other gelatin-derived compounds for the application of wound healing. An additional comparison is made with commercial dressings. The DS is directly proportional to the mechanical characteristics and inversely proportional to the swelling capacity. Gel-PE shows weaker mechanical properties (G ' < 15 kPa) than gel-AA and gel-MA (G ' < 39 and 45 kPa, respectively). All derivatives are predominantly elastic (recovery indices of 89-94%). Gel-AA and gel-MA show excellent biocompatibility, whereas gel-PE shows a significantly lower initial biocompatibility, evolving positively toward day 7. Overall, gel-MA shows to have the most potential to be applied as wound dressing. Future blending with gel-AA to improve the curing kinetics can lead to dressings able to compete with current commercial dressings.
- Keywords
- Materials Chemistry, Polymers and Plastics, Biomaterials, Bioengineering, Biotechnology, gelatin-(meth)acrylamide, gelatin-pentenamide, in vitro, mechanical characterization, photo-induced crosslinking, wound healing, TEXTURE PROFILE ANALYSIS, ALDER CLICK CHEMISTRY, FUNCTIONALIZED GELATIN, MECHANICAL-PROPERTIES, LINKING, POLYMER, PHOTOPOLYMERIZATIONS, CRYOGELS, ACRYLATE, SKIN
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8736661
- MLA
- Stubbe, Birgit, et al. “Photo‐crosslinked Gelatin‐based Hydrogel Films to Support Wound Healing.” MACROMOLECULAR BIOSCIENCE, vol. 21, no. 12, 2021, doi:10.1002/mabi.202100246.
- APA
- Stubbe, B., Mignon, A., Van Damme, L., Claes, K., Hoeksema, H., Monstrey, S., … Dubruel, P. (2021). Photo‐crosslinked gelatin‐based hydrogel films to support wound healing. MACROMOLECULAR BIOSCIENCE, 21(12). https://doi.org/10.1002/mabi.202100246
- Chicago author-date
- Stubbe, Birgit, Arn Mignon, Lana Van Damme, Karel Claes, Henk Hoeksema, Stan Monstrey, Sandra Van Vlierberghe, and Peter Dubruel. 2021. “Photo‐crosslinked Gelatin‐based Hydrogel Films to Support Wound Healing.” MACROMOLECULAR BIOSCIENCE 21 (12). https://doi.org/10.1002/mabi.202100246.
- Chicago author-date (all authors)
- Stubbe, Birgit, Arn Mignon, Lana Van Damme, Karel Claes, Henk Hoeksema, Stan Monstrey, Sandra Van Vlierberghe, and Peter Dubruel. 2021. “Photo‐crosslinked Gelatin‐based Hydrogel Films to Support Wound Healing.” MACROMOLECULAR BIOSCIENCE 21 (12). doi:10.1002/mabi.202100246.
- Vancouver
- 1.Stubbe B, Mignon A, Van Damme L, Claes K, Hoeksema H, Monstrey S, et al. Photo‐crosslinked gelatin‐based hydrogel films to support wound healing. MACROMOLECULAR BIOSCIENCE. 2021;21(12).
- IEEE
- [1]B. Stubbe et al., “Photo‐crosslinked gelatin‐based hydrogel films to support wound healing,” MACROMOLECULAR BIOSCIENCE, vol. 21, no. 12, 2021.
@article{8736661,
abstract = {{Gelatin is used widely in the biomedical field, among other for wound healing. Given its upper critical solution temperature, crosslinking is required. To this end, gelatin is chemically modified with different photo-crosslinkable moieties with low (32-34%) and high (63-65%) degree of substitution (DS): gelatin-methacrylamide (gel-MA) and gelatin-acrylamide (gel-AA) and gelatin-pentenamide (gel-PE). Next to the more researched gel-MA, it is especially interesting and novel to compare with other gelatin-derived compounds for the application of wound healing. An additional comparison is made with commercial dressings. The DS is directly proportional to the mechanical characteristics and inversely proportional to the swelling capacity. Gel-PE shows weaker mechanical properties (G ' < 15 kPa) than gel-AA and gel-MA (G ' < 39 and 45 kPa, respectively). All derivatives are predominantly elastic (recovery indices of 89-94%). Gel-AA and gel-MA show excellent biocompatibility, whereas gel-PE shows a significantly lower initial biocompatibility, evolving positively toward day 7. Overall, gel-MA shows to have the most potential to be applied as wound dressing. Future blending with gel-AA to improve the curing kinetics can lead to dressings able to compete with current commercial dressings.}},
articleno = {{2100246}},
author = {{Stubbe, Birgit and Mignon, Arn and Van Damme, Lana and Claes, Karel and Hoeksema, Henk and Monstrey, Stan and Van Vlierberghe, Sandra and Dubruel, Peter}},
issn = {{1616-5187}},
journal = {{MACROMOLECULAR BIOSCIENCE}},
keywords = {{Materials Chemistry,Polymers and Plastics,Biomaterials,Bioengineering,Biotechnology,gelatin-(meth)acrylamide,gelatin-pentenamide,in vitro,mechanical characterization,photo-induced crosslinking,wound healing,TEXTURE PROFILE ANALYSIS,ALDER CLICK CHEMISTRY,FUNCTIONALIZED GELATIN,MECHANICAL-PROPERTIES,LINKING,POLYMER,PHOTOPOLYMERIZATIONS,CRYOGELS,ACRYLATE,SKIN}},
language = {{eng}},
number = {{12}},
pages = {{15}},
title = {{Photo‐crosslinked gelatin‐based hydrogel films to support wound healing}},
url = {{http://doi.org/10.1002/mabi.202100246}},
volume = {{21}},
year = {{2021}},
}
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