Clinical relevance of serum Kyn/Trp ratio and basal and IFN gamma-upregulated IDO1 expression in peripheral monocytes in early stage melanoma
- Author
- Annabel Meireson, Liesbeth Ferdinande (UGent) , Marc Haspeslagh (UGent) , Benjamin Hennart, Delphine Allorge, Piet Ost (UGent) , Nora Sundahl, Mathieu Spaas (UGent) , Annelies Demeyer (UGent) and Lieve Brochez (UGent)
- Organization
- Abstract
- Immune escape is an early phenomenon in cancer development/progression. Indoleamine 2,3-dioxygenase 1 (IDO1) is a normal endogenous mechanism of acquired peripheral immune tolerance and may therefore be tumor-promoting. This study investigated the clinical relevance of IDO1 expression by immune cells in the lymph nodes and blood and of the serum kynurenine/tryptophan (Kyn/Trp) ratio in 65 systemic treatment naive stage I-III melanoma patients. Blood samples were collected within the first year of diagnosis. Patients had a median follow-up of 61 months. High basal IDO1 expression in peripheral monocytes and low IFN gamma-induced IDO1 upregulation correlated with worse outcome independent from disease stage. Interestingly studied factors were not interrelated. During follow-up, the risk of relapse was 9% (2/22) in the subgroup with high IFN gamma-induced IDO1 upregulation in monocytes. In contrast, if IDO1 upregulation was low, relapse occurred in 30% (3/10) of patients with low basal IDO1 expression in monocytes and in 61.5% (8/13) in the subgroup with high basal IDO1 expression in monocytes (Log-Rank test, p=0.008). This study reveals some immune features in the blood of early stage melanoma that may be of relevance for disease outcome. These may offer a target for sub-stratification and early intervention.
- Keywords
- INDOLEAMINE 2, 3-DIOXYGENASE ACTIVITY, TUMOR-INFILTRATING LYMPHOCYTES, KYNURENINE PATHWAY, THIN MELANOMAS, PAIRED PRIMARY, IMMUNE CELLS, TRYPTOPHAN, INHIBITION, MACROPHAGES, METABOLISM, early stage melanoma, biomarker, IDO1, Kyn, Trp, tryptophan metabolism, monocytes, immune cells, liquid biopsy
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8735979
- MLA
- Meireson, Annabel, et al. “Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFN Gamma-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma.” FRONTIERS IN IMMUNOLOGY, vol. 12, 2021, doi:10.3389/fimmu.2021.736498.
- APA
- Meireson, A., Ferdinande, L., Haspeslagh, M., Hennart, B., Allorge, D., Ost, P., … Brochez, L. (2021). Clinical relevance of serum Kyn/Trp ratio and basal and IFN gamma-upregulated IDO1 expression in peripheral monocytes in early stage melanoma. FRONTIERS IN IMMUNOLOGY, 12. https://doi.org/10.3389/fimmu.2021.736498
- Chicago author-date
- Meireson, Annabel, Liesbeth Ferdinande, Marc Haspeslagh, Benjamin Hennart, Delphine Allorge, Piet Ost, Nora Sundahl, Mathieu Spaas, Annelies Demeyer, and Lieve Brochez. 2021. “Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFN Gamma-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma.” FRONTIERS IN IMMUNOLOGY 12. https://doi.org/10.3389/fimmu.2021.736498.
- Chicago author-date (all authors)
- Meireson, Annabel, Liesbeth Ferdinande, Marc Haspeslagh, Benjamin Hennart, Delphine Allorge, Piet Ost, Nora Sundahl, Mathieu Spaas, Annelies Demeyer, and Lieve Brochez. 2021. “Clinical Relevance of Serum Kyn/Trp Ratio and Basal and IFN Gamma-Upregulated IDO1 Expression in Peripheral Monocytes in Early Stage Melanoma.” FRONTIERS IN IMMUNOLOGY 12. doi:10.3389/fimmu.2021.736498.
- Vancouver
- 1.Meireson A, Ferdinande L, Haspeslagh M, Hennart B, Allorge D, Ost P, et al. Clinical relevance of serum Kyn/Trp ratio and basal and IFN gamma-upregulated IDO1 expression in peripheral monocytes in early stage melanoma. FRONTIERS IN IMMUNOLOGY. 2021;12.
- IEEE
- [1]A. Meireson et al., “Clinical relevance of serum Kyn/Trp ratio and basal and IFN gamma-upregulated IDO1 expression in peripheral monocytes in early stage melanoma,” FRONTIERS IN IMMUNOLOGY, vol. 12, 2021.
@article{8735979, abstract = {{Immune escape is an early phenomenon in cancer development/progression. Indoleamine 2,3-dioxygenase 1 (IDO1) is a normal endogenous mechanism of acquired peripheral immune tolerance and may therefore be tumor-promoting. This study investigated the clinical relevance of IDO1 expression by immune cells in the lymph nodes and blood and of the serum kynurenine/tryptophan (Kyn/Trp) ratio in 65 systemic treatment naive stage I-III melanoma patients. Blood samples were collected within the first year of diagnosis. Patients had a median follow-up of 61 months. High basal IDO1 expression in peripheral monocytes and low IFN gamma-induced IDO1 upregulation correlated with worse outcome independent from disease stage. Interestingly studied factors were not interrelated. During follow-up, the risk of relapse was 9% (2/22) in the subgroup with high IFN gamma-induced IDO1 upregulation in monocytes. In contrast, if IDO1 upregulation was low, relapse occurred in 30% (3/10) of patients with low basal IDO1 expression in monocytes and in 61.5% (8/13) in the subgroup with high basal IDO1 expression in monocytes (Log-Rank test, p=0.008). This study reveals some immune features in the blood of early stage melanoma that may be of relevance for disease outcome. These may offer a target for sub-stratification and early intervention.}}, articleno = {{736498}}, author = {{Meireson, Annabel and Ferdinande, Liesbeth and Haspeslagh, Marc and Hennart, Benjamin and Allorge, Delphine and Ost, Piet and Sundahl, Nora and Spaas, Mathieu and Demeyer, Annelies and Brochez, Lieve}}, issn = {{1664-3224}}, journal = {{FRONTIERS IN IMMUNOLOGY}}, keywords = {{INDOLEAMINE 2,3-DIOXYGENASE ACTIVITY,TUMOR-INFILTRATING LYMPHOCYTES,KYNURENINE PATHWAY,THIN MELANOMAS,PAIRED PRIMARY,IMMUNE CELLS,TRYPTOPHAN,INHIBITION,MACROPHAGES,METABOLISM,early stage melanoma,biomarker,IDO1,Kyn,Trp,tryptophan metabolism,monocytes,immune cells,liquid biopsy}}, language = {{eng}}, pages = {{12}}, title = {{Clinical relevance of serum Kyn/Trp ratio and basal and IFN gamma-upregulated IDO1 expression in peripheral monocytes in early stage melanoma}}, url = {{http://doi.org/10.3389/fimmu.2021.736498}}, volume = {{12}}, year = {{2021}}, }
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