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Electrospinning of poly(decamethylene terephthalate) to support vascular graft applications

Babs Van de Voorde, Berna Şensu, Lobke De Vos (UGent) , Robin Colenbier, Havva Başkan, Jozefien Geltmeyer (UGent) , Laurens Parmentier (UGent) , Lenny Van Daele (UGent) , Ruslan Dmitriev (UGent) , Lincy Pyl, et al.
(2022) EUROPEAN POLYMER JOURNAL. 165.
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Abstract
Recently, poly(nonamethylene terephthalate) (PAT((n=9))) and poly(decamethylene terephthalate) (PAT((n=10))) gained increasing interest since it was reported to exhibit enhanced endothelial cell adhesion and viability compared to other poly(alkylene terephthalate) (PAT) analogues. Enhanced endothelial cell interactivity is of particular interest when targeting cardiovascular applications, more specifically, for creating synthetic vascular bypass grafts. In this study, the potential of PAT((n=10)) to be applied as synthetic bypass graft has been further investigated. After a thorough physico-chemical characterization of the synthesized PAT((n=10)), microsized fibers were processed via electrospinning. In a first part, the polymer-related parameters were investigated and optimized to obtain uniform beadless fibers. By changing the solution composition and device set-up, various fiber morphologies (i.e. random, aligned and porous fibers) were obtained and subjected to an in vitro biological evaluation with Human Umbilical Vein Endothelial Cells (HUVECs), while exploiting a clinically used synthetic graft (i.e. Dacron (R)) as benchmark. It was shown that the cells seeded onto all PAT((n=10)) fibers exhibited a superior metabolic activity compared to Dacron after 7 days of culture, while aligned and porous fibers had a beneficial effect on the survival of HUVECs. This study is a first step towards the application of PATs as novel cardiovascular bypass graft, fabricated via electrospinning.
Keywords
Organic Chemistry, Polymers and Plastics, General Physics and Astronomy, Materials Chemistry, Poly(decamethylene terephthalate), Electrospinning, Human Umbilical Vein Endothelial Cells, Live, dead staining, MOLECULAR-WEIGHT, POLYMER NANOFIBERS, SCAFFOLDS, BIOCOMPATIBILITY, DEGRADATION, BEHAVIOR, DENSITY

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MLA
Van de Voorde, Babs, et al. “Electrospinning of Poly(Decamethylene Terephthalate) to Support Vascular Graft Applications.” EUROPEAN POLYMER JOURNAL, vol. 165, 2022, doi:10.1016/j.eurpolymj.2022.111003.
APA
Van de Voorde, B., Şensu, B., De Vos, L., Colenbier, R., Başkan, H., Geltmeyer, J., … Van Vlierberghe, S. (2022). Electrospinning of poly(decamethylene terephthalate) to support vascular graft applications. EUROPEAN POLYMER JOURNAL, 165. https://doi.org/10.1016/j.eurpolymj.2022.111003
Chicago author-date
Van de Voorde, Babs, Berna Şensu, Lobke De Vos, Robin Colenbier, Havva Başkan, Jozefien Geltmeyer, Laurens Parmentier, et al. 2022. “Electrospinning of Poly(Decamethylene Terephthalate) to Support Vascular Graft Applications.” EUROPEAN POLYMER JOURNAL 165. https://doi.org/10.1016/j.eurpolymj.2022.111003.
Chicago author-date (all authors)
Van de Voorde, Babs, Berna Şensu, Lobke De Vos, Robin Colenbier, Havva Başkan, Jozefien Geltmeyer, Laurens Parmentier, Lenny Van Daele, Ruslan Dmitriev, Lincy Pyl, Karen De Clerck, and Sandra Van Vlierberghe. 2022. “Electrospinning of Poly(Decamethylene Terephthalate) to Support Vascular Graft Applications.” EUROPEAN POLYMER JOURNAL 165. doi:10.1016/j.eurpolymj.2022.111003.
Vancouver
1.
Van de Voorde B, Şensu B, De Vos L, Colenbier R, Başkan H, Geltmeyer J, et al. Electrospinning of poly(decamethylene terephthalate) to support vascular graft applications. EUROPEAN POLYMER JOURNAL. 2022;165.
IEEE
[1]
B. Van de Voorde et al., “Electrospinning of poly(decamethylene terephthalate) to support vascular graft applications,” EUROPEAN POLYMER JOURNAL, vol. 165, 2022.
@article{8735806,
  abstract     = {{Recently, poly(nonamethylene terephthalate) (PAT((n=9))) and poly(decamethylene terephthalate) (PAT((n=10))) gained increasing interest since it was reported to exhibit enhanced endothelial cell adhesion and viability compared to other poly(alkylene terephthalate) (PAT) analogues. Enhanced endothelial cell interactivity is of particular interest when targeting cardiovascular applications, more specifically, for creating synthetic vascular bypass grafts. In this study, the potential of PAT((n=10)) to be applied as synthetic bypass graft has been further investigated. After a thorough physico-chemical characterization of the synthesized PAT((n=10)), microsized fibers were processed via electrospinning. In a first part, the polymer-related parameters were investigated and optimized to obtain uniform beadless fibers. By changing the solution composition and device set-up, various fiber morphologies (i.e. random, aligned and porous fibers) were obtained and subjected to an in vitro biological evaluation with Human Umbilical Vein Endothelial Cells (HUVECs), while exploiting a clinically used synthetic graft (i.e. Dacron (R)) as benchmark. It was shown that the cells seeded onto all PAT((n=10)) fibers exhibited a superior metabolic activity compared to Dacron after 7 days of culture, while aligned and porous fibers had a beneficial effect on the survival of HUVECs. This study is a first step towards the application of PATs as novel cardiovascular bypass graft, fabricated via electrospinning.}},
  articleno    = {{111003}},
  author       = {{Van de Voorde, Babs and Şensu, Berna and De Vos, Lobke and Colenbier, Robin and Başkan, Havva and Geltmeyer, Jozefien and Parmentier, Laurens and Van Daele, Lenny and Dmitriev, Ruslan and Pyl, Lincy and De Clerck, Karen and Van Vlierberghe, Sandra}},
  issn         = {{0014-3057}},
  journal      = {{EUROPEAN POLYMER JOURNAL}},
  keywords     = {{Organic Chemistry,Polymers and Plastics,General Physics and Astronomy,Materials Chemistry,Poly(decamethylene terephthalate),Electrospinning,Human Umbilical Vein Endothelial Cells,Live,dead staining,MOLECULAR-WEIGHT,POLYMER NANOFIBERS,SCAFFOLDS,BIOCOMPATIBILITY,DEGRADATION,BEHAVIOR,DENSITY}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{Electrospinning of poly(decamethylene terephthalate) to support vascular graft applications}},
  url          = {{http://doi.org/10.1016/j.eurpolymj.2022.111003}},
  volume       = {{165}},
  year         = {{2022}},
}
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