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PIN auxin efflux carrier polarity is regulated by PINOID kinase-mediated recruitment into GNOM-independent trafficking in Arabidopsis

Jürgen Kleine-Vehn UGent, Fang Huang, Satoshi Naramoto UGent, Jing Zhang UGent, Marta Michniewicz, Remko Offringa and Jiri Friml UGent (2009) PLANT CELL. 21(12). p.3839-3849
abstract
The phytohormone auxin plays a major role in embryonic and postembryonic plant development. The temporal and spatial distribution of auxin largely depends on the subcellular polar localization of members of the PIN-FORMED (PIN) auxin efflux carrier family. The Ser/Thr protein kinase PINOID (PID) catalyzes PIN phosphorylation and crucially contributes to the regulation of apical-basal PIN polarity. The GTP exchange factor on ADP-ribosylation factors (ARF-GEF), GNOM preferentially mediates PIN recycling at the basal side of the cell. Interference with GNOM activity leads to dynamic PIN transcytosis between different sides of the cell. Our genetic, pharmacological, and cell biological approaches illustrate that PID and GNOM influence PIN polarity and plant development in an antagonistic manner and that the PID-dependent PIN phosphorylation results in GNOM-independent polar PIN targeting. The data suggest that PID and the protein phosphatase 2A not only regulate the static PIN polarity, but also act antagonistically on the rate of GNOM-dependent polar PIN transcytosis. We propose a model that includes PID-dependent PIN phosphorylation at the plasma membrane and the subsequent sorting of PIN proteins to a GNOM-independent pathway for polarity alterations during developmental processes, such as lateral root formation and leaf vasculature development.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CANALIZATION, PLANT DEVELOPMENT, GRADIENTS, LOCALIZATION, CELLS, TRANSPORT, ARF-GEF, PROTEIN, FLOW, TRANSCYTOSIS
journal title
PLANT CELL
Plant Cell
volume
21
issue
12
pages
3839 - 3849
Web of Science type
Article
Web of Science id
000274196000011
JCR category
PLANT SCIENCES
JCR impact factor
9.293 (2009)
JCR rank
5/172 (2009)
JCR quartile
1 (2009)
ISSN
1040-4651
DOI
10.1105/tpc.109.071639
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
873580
handle
http://hdl.handle.net/1854/LU-873580
date created
2010-02-22 14:57:37
date last changed
2012-12-18 13:40:13
@article{873580,
  abstract     = {The phytohormone auxin plays a major role in embryonic and postembryonic plant development. The temporal and spatial distribution of auxin largely depends on the subcellular polar localization of members of the PIN-FORMED (PIN) auxin efflux carrier family. The Ser/Thr protein kinase PINOID (PID) catalyzes PIN phosphorylation and crucially contributes to the regulation of apical-basal PIN polarity. The GTP exchange factor on ADP-ribosylation factors (ARF-GEF), GNOM preferentially mediates PIN recycling at the basal side of the cell. Interference with GNOM activity leads to dynamic PIN transcytosis between different sides of the cell. Our genetic, pharmacological, and cell biological approaches illustrate that PID and GNOM influence PIN polarity and plant development in an antagonistic manner and that the PID-dependent PIN phosphorylation results in GNOM-independent polar PIN targeting. The data suggest that PID and the protein phosphatase 2A not only regulate the static PIN polarity, but also act antagonistically on the rate of GNOM-dependent polar PIN transcytosis. We propose a model that includes PID-dependent PIN phosphorylation at the plasma membrane and the subsequent sorting of PIN proteins to a GNOM-independent pathway for polarity alterations during developmental processes, such as lateral root formation and leaf vasculature development.},
  author       = {Kleine-Vehn, J{\"u}rgen and Huang, Fang and Naramoto, Satoshi and Zhang, Jing and Michniewicz, Marta and Offringa, Remko and Friml, Jiri},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {CANALIZATION,PLANT DEVELOPMENT,GRADIENTS,LOCALIZATION,CELLS,TRANSPORT,ARF-GEF,PROTEIN,FLOW,TRANSCYTOSIS},
  language     = {eng},
  number       = {12},
  pages        = {3839--3849},
  title        = {PIN auxin efflux carrier polarity is regulated by PINOID kinase-mediated recruitment into GNOM-independent trafficking in Arabidopsis},
  url          = {http://dx.doi.org/10.1105/tpc.109.071639},
  volume       = {21},
  year         = {2009},
}

Chicago
Kleine-Vehn, Jürgen, Fang Huang, Satoshi Naramoto, Jing Zhang, Marta Michniewicz, Remko Offringa, and Jiri Friml. 2009. “PIN Auxin Efflux Carrier Polarity Is Regulated by PINOID Kinase-mediated Recruitment into GNOM-independent Trafficking in Arabidopsis.” Plant Cell 21 (12): 3839–3849.
APA
Kleine-Vehn, J., Huang, F., Naramoto, S., Zhang, J., Michniewicz, M., Offringa, R., & Friml, J. (2009). PIN auxin efflux carrier polarity is regulated by PINOID kinase-mediated recruitment into GNOM-independent trafficking in Arabidopsis. PLANT CELL, 21(12), 3839–3849.
Vancouver
1.
Kleine-Vehn J, Huang F, Naramoto S, Zhang J, Michniewicz M, Offringa R, et al. PIN auxin efflux carrier polarity is regulated by PINOID kinase-mediated recruitment into GNOM-independent trafficking in Arabidopsis. PLANT CELL. 2009;21(12):3839–49.
MLA
Kleine-Vehn, Jürgen, Fang Huang, Satoshi Naramoto, et al. “PIN Auxin Efflux Carrier Polarity Is Regulated by PINOID Kinase-mediated Recruitment into GNOM-independent Trafficking in Arabidopsis.” PLANT CELL 21.12 (2009): 3839–3849. Print.