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The PIN-FORMED (PIN) protein family of auxin transporters

Pavel Krecek, Petr Skupa, Jiri Libus, Satoshi Naramoto UGent, Ricardo Tejos Ulloa UGent, Jiri Friml UGent and Eva Zazimalova (2009) GENOME BIOLOGY. 10(12).
abstract
The PIN-FORMED (PIN) proteins are secondary transporters acting in the efflux of the plant signal molecule auxin from cells. They are asymmetrically localized within cells and their polarity determines the directionality of intercellular auxin flow. PIN genes are found exclusively in the genomes of multicellular plants and play an important role in regulating asymmetric auxin distribution in multiple developmental processes, including embryogenesis, organogenesis, tissue differentiation and tropic responses. All PIN proteins have a similar structure with amino- and carboxy-terminal hydrophobic, membrane-spanning domains separated by a central hydrophilic domain. The structure of the hydrophobic domains is well conserved. The hydrophilic domain is more divergent and it determines eight groups within the protein family. The activity of PIN proteins is regulated at multiple levels, including transcription, protein stability, subcellular localization and transport activity. Different endogenous and environmental signals can modulate PIN activity and thus modulate auxin-distribution-dependent development. A large group of PIN proteins, including the most ancient members known from mosses, localize to the endoplasmic reticulum and they regulate the subcellular compartmentalization of auxin and thus auxin metabolism. Further work is needed to establish the physiological importance of this unexpected mode of auxin homeostasis regulation. Furthermore, the evolution of PIN-based transport, PIN protein structure and more detailed biochemical characterization of the transport function are important topics for further studies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
ARABIDOPSIS-THALIANA, PLANT DEVELOPMENT, EFFLUX CARRIER, ROOT GRAVITROPISM, POLAR TRANSPORT, EXPRESSION, GENE, BIOSYNTHESIS, MERISTEM, GRADIENTS
journal title
GENOME BIOLOGY
Genome Biol.
volume
10
issue
12
pages
11 pages
publisher
BIOMED CENTRAL LTD
place of publication
LONDON
Web of Science type
Review
Web of Science id
000274289000004
JCR category
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
JCR impact factor
6.626 (2009)
JCR rank
10/150 (2009)
JCR quartile
1 (2009)
ISSN
1474-760X
DOI
10.1186/gb-2009-10-12-249
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
873570
handle
http://hdl.handle.net/1854/LU-873570
date created
2010-02-22 14:57:11
date last changed
2010-03-04 14:21:43
@article{873570,
  abstract     = {The PIN-FORMED (PIN) proteins are secondary transporters acting in the efflux of the plant signal molecule auxin from cells. They are asymmetrically localized within cells and their polarity determines the directionality of intercellular auxin flow. PIN genes are found exclusively in the genomes of multicellular plants and play an important role in regulating asymmetric auxin distribution in multiple developmental processes, including embryogenesis, organogenesis, tissue differentiation and tropic responses. All PIN proteins have a similar structure with amino- and carboxy-terminal hydrophobic, membrane-spanning domains separated by a central hydrophilic domain. The structure of the hydrophobic domains is well conserved. The hydrophilic domain is more divergent and it determines eight groups within the protein family. The activity of PIN proteins is regulated at multiple levels, including transcription, protein stability, subcellular localization and transport activity. Different endogenous and environmental signals can modulate PIN activity and thus modulate auxin-distribution-dependent development. A large group of PIN proteins, including the most ancient members known from mosses, localize to the endoplasmic reticulum and they regulate the subcellular compartmentalization of auxin and thus auxin metabolism. Further work is needed to establish the physiological importance of this unexpected mode of auxin homeostasis regulation. Furthermore, the evolution of PIN-based transport, PIN protein structure and more detailed biochemical characterization of the transport function are important topics for further studies.},
  author       = {Krecek, Pavel and Skupa, Petr and Libus, Jiri and Naramoto, Satoshi and Tejos Ulloa, Ricardo and Friml, Jiri and Zazimalova, Eva},
  issn         = {1474-760X},
  journal      = {GENOME BIOLOGY},
  keyword      = {ARABIDOPSIS-THALIANA,PLANT DEVELOPMENT,EFFLUX CARRIER,ROOT GRAVITROPISM,POLAR TRANSPORT,EXPRESSION,GENE,BIOSYNTHESIS,MERISTEM,GRADIENTS},
  language     = {eng},
  number       = {12},
  pages        = {11},
  publisher    = {BIOMED CENTRAL LTD},
  title        = {The PIN-FORMED (PIN) protein family of auxin transporters},
  url          = {http://dx.doi.org/10.1186/gb-2009-10-12-249},
  volume       = {10},
  year         = {2009},
}

Chicago
Krecek, Pavel, Petr Skupa, Jiri Libus, Satoshi Naramoto, Ricardo Tejos Ulloa, Jiri Friml, and Eva Zazimalova. 2009. “The PIN-FORMED (PIN) Protein Family of Auxin Transporters.” Genome Biology 10 (12).
APA
Krecek, P., Skupa, P., Libus, J., Naramoto, S., Tejos Ulloa, R., Friml, J., & Zazimalova, E. (2009). The PIN-FORMED (PIN) protein family of auxin transporters. GENOME BIOLOGY, 10(12).
Vancouver
1.
Krecek P, Skupa P, Libus J, Naramoto S, Tejos Ulloa R, Friml J, et al. The PIN-FORMED (PIN) protein family of auxin transporters. GENOME BIOLOGY. LONDON: BIOMED CENTRAL LTD; 2009;10(12).
MLA
Krecek, Pavel, Petr Skupa, Jiri Libus, et al. “The PIN-FORMED (PIN) Protein Family of Auxin Transporters.” GENOME BIOLOGY 10.12 (2009): n. pag. Print.