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Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1

Nico Dissmeyer, Annika K Weimer, Stefan Pusch, Kristof De Schutter UGent, Claire Lessa Alvim Kamei UGent, Moritz Nowack UGent, Bela Novak, Gui-Lan Duan, Yong-Guan Zhu and Lieven De Veylder UGent, et al. (2009) PLANT CELL. 21(11). p.3641-3654
abstract
Entry into mitosis is universally controlled by cyclin-dependent kinases (CDKs). A key regulatory event in metazoans and fission yeast is CDK activation by the removal of inhibitory phosphate groups in the ATP binding pocket catalyzed by Cdc25 phosphatases. In contrast with other multicellular organisms, we show here that in the flowering plant Arabidopsis thaliana, cell cycle control does not depend on sudden changes in the phosphorylation pattern of the PSTAIRE-containing Cdk1 homolog CDKA;1. Consistently, we found that neither mutants in a previously identified CDC25 candidate gene nor plants in which it is overexpressed display cell cycle defects. Inhibitory phosphorylation of CDKs is also the key event in metazoans to arrest cell cycle progression upon DNA damage. However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1. These observations reveal a surprising degree of divergence in the circuitry of highly conserved core cell cycle regulators in multicellular organisms. Based on biomathematical simulations, we propose a plant-specific model of how progression through the cell cycle could be wired in Arabidopsis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
THALIANA, TYROSINE PHOSPHORYLATION, CYCLIN-DEPENDENT-KINASE, PROTEIN-KINASE, FISSION YEAST, SACCHAROMYCES-CEREVISIAE, BUDDING YEAST, MORPHOGENESIS CHECKPOINT, PLANT DEVELOPMENT, WEE1
journal title
PLANT CELL
Plant Cell
volume
21
issue
11
pages
3641 - 3654
Web of Science type
Article
Web of Science id
000273235600020
JCR category
PLANT SCIENCES
JCR impact factor
9.293 (2009)
JCR rank
5/172 (2009)
JCR quartile
1 (2009)
ISSN
1040-4651
DOI
10.1105/tpc.109.070417
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
873542
handle
http://hdl.handle.net/1854/LU-873542
date created
2010-02-22 14:56:58
date last changed
2012-12-18 13:36:01
@article{873542,
  abstract     = {Entry into mitosis is universally controlled by cyclin-dependent kinases (CDKs). A key regulatory event in metazoans and fission yeast is CDK activation by the removal of inhibitory phosphate groups in the ATP binding pocket catalyzed by Cdc25 phosphatases. In contrast with other multicellular organisms, we show here that in the flowering plant Arabidopsis thaliana, cell cycle control does not depend on sudden changes in the phosphorylation pattern of the PSTAIRE-containing Cdk1 homolog CDKA;1. Consistently, we found that neither mutants in a previously identified CDC25 candidate gene nor plants in which it is overexpressed display cell cycle defects. Inhibitory phosphorylation of CDKs is also the key event in metazoans to arrest cell cycle progression upon DNA damage. However, we show here that the DNA damage checkpoint in Arabidopsis can also operate independently of the phosphorylation of CDKA;1. These observations reveal a surprising degree of divergence in the circuitry of highly conserved core cell cycle regulators in multicellular organisms. Based on biomathematical simulations, we propose a plant-specific model of how progression through the cell cycle could be wired in Arabidopsis.},
  author       = {Dissmeyer, Nico and Weimer, Annika K and Pusch, Stefan and De Schutter, Kristof and Lessa Alvim Kamei, Claire and Nowack, Moritz and Novak, Bela and Duan, Gui-Lan and Zhu, Yong-Guan and De Veylder, Lieven and Schnittger, Arp},
  issn         = {1040-4651},
  journal      = {PLANT CELL},
  keyword      = {THALIANA,TYROSINE PHOSPHORYLATION,CYCLIN-DEPENDENT-KINASE,PROTEIN-KINASE,FISSION YEAST,SACCHAROMYCES-CEREVISIAE,BUDDING YEAST,MORPHOGENESIS CHECKPOINT,PLANT DEVELOPMENT,WEE1},
  language     = {eng},
  number       = {11},
  pages        = {3641--3654},
  title        = {Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1},
  url          = {http://dx.doi.org/10.1105/tpc.109.070417},
  volume       = {21},
  year         = {2009},
}

Chicago
Dissmeyer, Nico, Annika K Weimer, Stefan Pusch, Kristof De Schutter, Claire Lessa Alvim Kamei, Moritz Nowack, Bela Novak, et al. 2009. “Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1.” Plant Cell 21 (11): 3641–3654.
APA
Dissmeyer, N., Weimer, A. K., Pusch, S., De Schutter, K., Lessa Alvim Kamei, C., Nowack, M., Novak, B., et al. (2009). Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1. PLANT CELL, 21(11), 3641–3654.
Vancouver
1.
Dissmeyer N, Weimer AK, Pusch S, De Schutter K, Lessa Alvim Kamei C, Nowack M, et al. Control of cell proliferation, organ growth, and DNA damage response operate independently of dephosphorylation of the Arabidopsis Cdk1 homolog CDKA;1. PLANT CELL. 2009;21(11):3641–54.
MLA
Dissmeyer, Nico, Annika K Weimer, Stefan Pusch, et al. “Control of Cell Proliferation, Organ Growth, and DNA Damage Response Operate Independently of Dephosphorylation of the Arabidopsis Cdk1 Homolog CDKA;1.” PLANT CELL 21.11 (2009): 3641–3654. Print.