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Clinical performance of seven prescreening tools for osteoporosis in Iranian postmenopausal women

(2015) RHEUMATOLOGY INTERNATIONAL. 35(12). p.1995-2004
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Abstract
This study was designed to evaluate seven prescreening osteoporosis models in postmenopausal Iranian women. This study was performed on 8644 postmenopausal women who have been referred for bone mineral densitometry (BMD) in BMD center of Shariati hospital in Tehran between 2001 and 2011. Diagnostic properties of seven prescreening instruments were evaluated. With regard to area under curve (AUC), these models have low accuracy (AUC a parts per thousand currency sign 0.65). Considering only femoral neck or total femur area, these models had low accuracy but were more sensitive. Except for three models with sensitivities of a parts per thousand currency sign65 % in both osteoporosis and fracture threshold, other models were around 70 % sensitive. However, these models were not considered clinically useful regarding their positive predictive values (PPV) especially in BMDs a parts per thousand currency sign02.5. With regard to different measures of diagnostic property, none of these models were good screening tools for osteoporosis or fracture threshold. Although some of them are sensitive, considering other measures such as PPV indicates that they are not completely useful for clinical use. Attempts should be made for developing newer prescreening methods and calibration of the existing models with regard to the studied population.
Keywords
Immunology, Immunology and Allergy, Rheumatology, Osteoporosis, Prescreening tools, Model performance, Diagnostic property, BONE-MINERAL DENSITY, RISK-ASSESSMENT TOOLS, SELF-ASSESSMENT TOOL, DECISION RULES, FACILITATE SELECTION, VALIDATION, INTERVENTION, IDENTIFICATION, DENSITOMETRY, ALENDRONATE

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MLA
Keshtkar, Abbas, et al. “Clinical Performance of Seven Prescreening Tools for Osteoporosis in Iranian Postmenopausal Women.” RHEUMATOLOGY INTERNATIONAL, vol. 35, no. 12, 2015, pp. 1995–2004, doi:10.1007/s00296-015-3286-1.
APA
Keshtkar, A., Tabatabaie, O., Matin, N., Mohammadi, Z., Ebrahimi, M., Khashayar, P., & Asadi, M. (2015). Clinical performance of seven prescreening tools for osteoporosis in Iranian postmenopausal women. RHEUMATOLOGY INTERNATIONAL, 35(12), 1995–2004. https://doi.org/10.1007/s00296-015-3286-1
Chicago author-date
Keshtkar, Abbas, Omidreza Tabatabaie, Nassim Matin, Zahra Mohammadi, Mehdi Ebrahimi, Patricia Khashayar, and Mojgan Asadi. 2015. “Clinical Performance of Seven Prescreening Tools for Osteoporosis in Iranian Postmenopausal Women.” RHEUMATOLOGY INTERNATIONAL 35 (12): 1995–2004. https://doi.org/10.1007/s00296-015-3286-1.
Chicago author-date (all authors)
Keshtkar, Abbas, Omidreza Tabatabaie, Nassim Matin, Zahra Mohammadi, Mehdi Ebrahimi, Patricia Khashayar, and Mojgan Asadi. 2015. “Clinical Performance of Seven Prescreening Tools for Osteoporosis in Iranian Postmenopausal Women.” RHEUMATOLOGY INTERNATIONAL 35 (12): 1995–2004. doi:10.1007/s00296-015-3286-1.
Vancouver
1.
Keshtkar A, Tabatabaie O, Matin N, Mohammadi Z, Ebrahimi M, Khashayar P, et al. Clinical performance of seven prescreening tools for osteoporosis in Iranian postmenopausal women. RHEUMATOLOGY INTERNATIONAL. 2015;35(12):1995–2004.
IEEE
[1]
A. Keshtkar et al., “Clinical performance of seven prescreening tools for osteoporosis in Iranian postmenopausal women,” RHEUMATOLOGY INTERNATIONAL, vol. 35, no. 12, pp. 1995–2004, 2015.
@article{8735326,
  abstract     = {{This study was designed to evaluate seven prescreening osteoporosis models in postmenopausal Iranian women. This study was performed on 8644 postmenopausal women who have been referred for bone mineral densitometry (BMD) in BMD center of Shariati hospital in Tehran between 2001 and 2011. Diagnostic properties of seven prescreening instruments were evaluated. With regard to area under curve (AUC), these models have low accuracy (AUC a parts per thousand currency sign 0.65). Considering only femoral neck or total femur area, these models had low accuracy but were more sensitive. Except for three models with sensitivities of a parts per thousand currency sign65 % in both osteoporosis and fracture threshold, other models were around 70 % sensitive. However, these models were not considered clinically useful regarding their positive predictive values (PPV) especially in BMDs a parts per thousand currency sign02.5. With regard to different measures of diagnostic property, none of these models were good screening tools for osteoporosis or fracture threshold. Although some of them are sensitive, considering other measures such as PPV indicates that they are not completely useful for clinical use. Attempts should be made for developing newer prescreening methods and calibration of the existing models with regard to the studied population.}},
  author       = {{Keshtkar, Abbas and Tabatabaie, Omidreza and Matin, Nassim and Mohammadi, Zahra and Ebrahimi, Mehdi and Khashayar, Patricia and Asadi, Mojgan}},
  issn         = {{0172-8172}},
  journal      = {{RHEUMATOLOGY INTERNATIONAL}},
  keywords     = {{Immunology,Immunology and Allergy,Rheumatology,Osteoporosis,Prescreening tools,Model performance,Diagnostic property,BONE-MINERAL DENSITY,RISK-ASSESSMENT TOOLS,SELF-ASSESSMENT TOOL,DECISION RULES,FACILITATE SELECTION,VALIDATION,INTERVENTION,IDENTIFICATION,DENSITOMETRY,ALENDRONATE}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1995--2004}},
  title        = {{Clinical performance of seven prescreening tools for osteoporosis in Iranian postmenopausal women}},
  url          = {{http://dx.doi.org/10.1007/s00296-015-3286-1}},
  volume       = {{35}},
  year         = {{2015}},
}

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