Malignant pleural mesothelioma with an EML4-ALK fusion : expect the unexpected!
- Author
- Fleur Cordier (UGent) , Joni Van der Meulen (UGent) , Nadine Van Roy (UGent) , Jilke De Wilde (UGent) , Herwig van Dijck, Filip Vanhoenacker (UGent) , Marc Lambrechts, Valentin Noyez, Koen Van de Vijver (UGent) , Liesbeth Ferdinande (UGent) , Amélie Dendooven (UGent) , Jo Van Dorpe (UGent) and David Creytens (UGent)
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- Abstract
- Case report of malignant pleural mesothelioma with an ALK gene rearrangement, detected by FISH and confirmed by RNA-based next-generation sequencing. The co-occurrence of ALK gene fusions with the more common genetic alterations in CDKN2A, NF2 and BAP1 has, to our best knowledge, not yet been described in malignant mesothelioma. Furthermore, this unexpected finding could suggest a potential target for therapy in this subset of malignant mesotheliomas.
- Keywords
- Cell Biology, Pathology and Forensic Medicine, Pleural mesothelioma, ALK fusion, Immunohistochemistry, Molecular techniques, Copy-number variation sequencing, Next-generation sequencing, PERITONEAL MESOTHELIOMA, ALK REARRANGEMENTS, METHYLATION, EXPRESSION, TUMORS, DNA, CHILDREN, CANCER, RARE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8734965
- MLA
- Cordier, Fleur, et al. “Malignant Pleural Mesothelioma with an EML4-ALK Fusion : Expect the Unexpected!” PATHOLOGY RESEARCH AND PRACTICE, vol. 231, 2022, doi:10.1016/j.prp.2022.153772.
- APA
- Cordier, F., Van der Meulen, J., Van Roy, N., De Wilde, J., van Dijck, H., Vanhoenacker, F., … Creytens, D. (2022). Malignant pleural mesothelioma with an EML4-ALK fusion : expect the unexpected! PATHOLOGY RESEARCH AND PRACTICE, 231. https://doi.org/10.1016/j.prp.2022.153772
- Chicago author-date
- Cordier, Fleur, Joni Van der Meulen, Nadine Van Roy, Jilke De Wilde, Herwig van Dijck, Filip Vanhoenacker, Marc Lambrechts, et al. 2022. “Malignant Pleural Mesothelioma with an EML4-ALK Fusion : Expect the Unexpected!” PATHOLOGY RESEARCH AND PRACTICE 231. https://doi.org/10.1016/j.prp.2022.153772.
- Chicago author-date (all authors)
- Cordier, Fleur, Joni Van der Meulen, Nadine Van Roy, Jilke De Wilde, Herwig van Dijck, Filip Vanhoenacker, Marc Lambrechts, Valentin Noyez, Koen Van de Vijver, Liesbeth Ferdinande, Amélie Dendooven, Jo Van Dorpe, and David Creytens. 2022. “Malignant Pleural Mesothelioma with an EML4-ALK Fusion : Expect the Unexpected!” PATHOLOGY RESEARCH AND PRACTICE 231. doi:10.1016/j.prp.2022.153772.
- Vancouver
- 1.Cordier F, Van der Meulen J, Van Roy N, De Wilde J, van Dijck H, Vanhoenacker F, et al. Malignant pleural mesothelioma with an EML4-ALK fusion : expect the unexpected! PATHOLOGY RESEARCH AND PRACTICE. 2022;231.
- IEEE
- [1]F. Cordier et al., “Malignant pleural mesothelioma with an EML4-ALK fusion : expect the unexpected!,” PATHOLOGY RESEARCH AND PRACTICE, vol. 231, 2022.
@article{8734965,
abstract = {{Case report of malignant pleural mesothelioma with an ALK gene rearrangement, detected by FISH and confirmed by RNA-based next-generation sequencing. The co-occurrence of ALK gene fusions with the more common genetic alterations in CDKN2A, NF2 and BAP1 has, to our best knowledge, not yet been described in malignant mesothelioma. Furthermore, this unexpected finding could suggest a potential target for therapy in this subset of malignant mesotheliomas.}},
articleno = {{153772}},
author = {{Cordier, Fleur and Van der Meulen, Joni and Van Roy, Nadine and De Wilde, Jilke and van Dijck, Herwig and Vanhoenacker, Filip and Lambrechts, Marc and Noyez, Valentin and Van de Vijver, Koen and Ferdinande, Liesbeth and Dendooven, Amélie and Van Dorpe, Jo and Creytens, David}},
issn = {{0344-0338}},
journal = {{PATHOLOGY RESEARCH AND PRACTICE}},
keywords = {{Cell Biology,Pathology and Forensic Medicine,Pleural mesothelioma,ALK fusion,Immunohistochemistry,Molecular techniques,Copy-number variation sequencing,Next-generation sequencing,PERITONEAL MESOTHELIOMA,ALK REARRANGEMENTS,METHYLATION,EXPRESSION,TUMORS,DNA,CHILDREN,CANCER,RARE}},
language = {{eng}},
pages = {{6}},
title = {{Malignant pleural mesothelioma with an EML4-ALK fusion : expect the unexpected!}},
url = {{http://doi.org/10.1016/j.prp.2022.153772}},
volume = {{231}},
year = {{2022}},
}
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