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The donor-dependent and colon-region-dependent metabolism of (+)-catechin by colonic microbiota in the simulator of the human intestinal microbial ecosystem

Qiqiong Li, Florence Van Herreweghen (UGent) , Marjan De Mey (UGent) , Geert Goeminne (UGent) and Tom Van de Wiele (UGent)
(2022) MOLECULES. 27(1).
Author
Organization
Abstract
The intestinal absorption of dietary catechins is quite low, resulting in most of them being metabolized by gut microbiota in the colon. It has been hypothesized that microbiota-derived metabolites may be partly responsible for the association between catechin consumption and beneficial cardiometabolic effects. Given the profound differences in gut microbiota composition and microbial load between individuals and across different colon regions, this study examined how microbial (+)-catechin metabolite profiles differ between colon regions and individuals. Batch exploration of the interindividual variability in (+)-catechin microbial metabolism resulted in a stratification based on metabolic efficiency: from the 12 tested donor microbiota, we identified a fast- and a slow-converting microbiota that was subsequently inoculated to SHIME, a dynamic model of the human gut. Monitoring of microbial (+)-catechin metabolites from proximal and distal colon compartments with UHPLC-MS and UPLC-IMS-Q-TOF-MS revealed profound donor-dependent and colon-region-dependent metabolite profiles with 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone being the largest contributor to differences between the fast- and slow-converting microbiota and the distal colon being a more important region for (+)-catechin metabolism than the proximal colon. Our findings may contribute to further understanding the role of the gut microbiota as a determinant of interindividual variation in pharmacokinetics upon (+)-catechin ingestion.
Keywords
Chemistry (miscellaneous), Analytical Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Molecular Medicine, Drug Discovery, Pharmaceutical Science, catechins, metabolites, identification and quantification, metabolic pathway, gut microbiota, SHIME system, TEA POLYPHENOLS, GREEN TEA, C-RING, (-)-EPICATECHIN, FLAVAN-3-OLS, BIOTRANSFORMATION, CATABOLISM, CATECHINS, PROFILE

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Citation

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MLA
Li, Qiqiong, et al. “The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem.” MOLECULES, vol. 27, no. 1, 2022, doi:10.3390/molecules27010073.
APA
Li, Q., Van Herreweghen, F., De Mey, M., Goeminne, G., & Van de Wiele, T. (2022). The donor-dependent and colon-region-dependent metabolism of (+)-catechin by colonic microbiota in the simulator of the human intestinal microbial ecosystem. MOLECULES, 27(1). https://doi.org/10.3390/molecules27010073
Chicago author-date
Li, Qiqiong, Florence Van Herreweghen, Marjan De Mey, Geert Goeminne, and Tom Van de Wiele. 2022. “The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem.” MOLECULES 27 (1). https://doi.org/10.3390/molecules27010073.
Chicago author-date (all authors)
Li, Qiqiong, Florence Van Herreweghen, Marjan De Mey, Geert Goeminne, and Tom Van de Wiele. 2022. “The Donor-Dependent and Colon-Region-Dependent Metabolism of (+)-Catechin by Colonic Microbiota in the Simulator of the Human Intestinal Microbial Ecosystem.” MOLECULES 27 (1). doi:10.3390/molecules27010073.
Vancouver
1.
Li Q, Van Herreweghen F, De Mey M, Goeminne G, Van de Wiele T. The donor-dependent and colon-region-dependent metabolism of (+)-catechin by colonic microbiota in the simulator of the human intestinal microbial ecosystem. MOLECULES. 2022;27(1).
IEEE
[1]
Q. Li, F. Van Herreweghen, M. De Mey, G. Goeminne, and T. Van de Wiele, “The donor-dependent and colon-region-dependent metabolism of (+)-catechin by colonic microbiota in the simulator of the human intestinal microbial ecosystem,” MOLECULES, vol. 27, no. 1, 2022.
@article{8733411,
  abstract     = {{The intestinal absorption of dietary catechins is quite low, resulting in most of them being metabolized by gut microbiota in the colon. It has been hypothesized that microbiota-derived metabolites may be partly responsible for the association between catechin consumption and beneficial cardiometabolic effects. Given the profound differences in gut microbiota composition and microbial load between individuals and across different colon regions, this study examined how microbial (+)-catechin metabolite profiles differ between colon regions and individuals. Batch exploration of the interindividual variability in (+)-catechin microbial metabolism resulted in a stratification based on metabolic efficiency: from the 12 tested donor microbiota, we identified a fast- and a slow-converting microbiota that was subsequently inoculated to SHIME, a dynamic model of the human gut. Monitoring of microbial (+)-catechin metabolites from proximal and distal colon compartments with UHPLC-MS and UPLC-IMS-Q-TOF-MS revealed profound donor-dependent and colon-region-dependent metabolite profiles with 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone being the largest contributor to differences between the fast- and slow-converting microbiota and the distal colon being a more important region for (+)-catechin metabolism than the proximal colon. Our findings may contribute to further understanding the role of the gut microbiota as a determinant of interindividual variation in pharmacokinetics upon (+)-catechin ingestion.}},
  articleno    = {{73}},
  author       = {{Li, Qiqiong and Van Herreweghen, Florence and De Mey, Marjan and Goeminne, Geert and Van de Wiele, Tom}},
  issn         = {{1420-3049}},
  journal      = {{MOLECULES}},
  keywords     = {{Chemistry (miscellaneous),Analytical Chemistry,Organic Chemistry,Physical and Theoretical Chemistry,Molecular Medicine,Drug Discovery,Pharmaceutical Science,catechins,metabolites,identification and quantification,metabolic pathway,gut microbiota,SHIME system,TEA POLYPHENOLS,GREEN TEA,C-RING,(-)-EPICATECHIN,FLAVAN-3-OLS,BIOTRANSFORMATION,CATABOLISM,CATECHINS,PROFILE}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{13}},
  title        = {{The donor-dependent and colon-region-dependent metabolism of (+)-catechin by colonic microbiota in the simulator of the human intestinal microbial ecosystem}},
  url          = {{http://doi.org/10.3390/molecules27010073}},
  volume       = {{27}},
  year         = {{2022}},
}
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