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Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization

Pawel Roszak, Jung-ok Heo, Bernhard Blob, Koichi Toyokura, Yuki Sugiyama, Maria Angels de Luis Balaguer, Winnie W. Y. Lau, Fiona Hamey, Jacopo Cirrone, Ewelina Madej, et al.
(2021) SCIENCE. 374(6575).
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Abstract
In the plant meristem, tissue-wide maturation gradients are coordinated with specialized cell networks to establish various developmental phases required for indeterminate growth. Here, we used single-cell transcriptomics to reconstruct the protophloem developmental trajectory from the birth of cell progenitors to terminal differentiation in the Arabidopsis thaliana root. PHLOEM EARLY DNA-BINDING WITH-ONE-FINGER (PEAR) transcription factors mediate lineage bifurcation by activating guanosine triphosphatase signaling and prime a transcriptional differentiation program. This program is initially repressed by a meristem-wide gradient of PLETHORA transcription factors. Only the dissipation of PLETHORA gradient permits activation of the differentiation program that involves mutual inhibition of early versus late meristem regulators. Thus, for phloem development, broad maturation gradients interface with cell-type-specific transcriptional regulators to stage cellular differentiation
Keywords
Multidisciplinary, REGULATORY NETWORK, RNA-SEQ, ROOT, GTPASES, GROWTH, GENE, MORPHOGENESIS, REVEALS, RHO, EXPRESSION

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Citation

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MLA
Roszak, Pawel, et al. “Cell-by-Cell Dissection of Phloem Development Links a Maturation Gradient to Cell Specialization.” SCIENCE, vol. 374, no. 6575, 2021, doi:10.1126/science.aba5531.
APA
Roszak, P., Heo, J., Blob, B., Toyokura, K., Sugiyama, Y., de Luis Balaguer, M. A., … Helariutta, Y. (2021). Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization. SCIENCE, 374(6575). https://doi.org/10.1126/science.aba5531
Chicago author-date
Roszak, Pawel, Jung-ok Heo, Bernhard Blob, Koichi Toyokura, Yuki Sugiyama, Maria Angels de Luis Balaguer, Winnie W. Y. Lau, et al. 2021. “Cell-by-Cell Dissection of Phloem Development Links a Maturation Gradient to Cell Specialization.” SCIENCE 374 (6575). https://doi.org/10.1126/science.aba5531.
Chicago author-date (all authors)
Roszak, Pawel, Jung-ok Heo, Bernhard Blob, Koichi Toyokura, Yuki Sugiyama, Maria Angels de Luis Balaguer, Winnie W. Y. Lau, Fiona Hamey, Jacopo Cirrone, Ewelina Madej, Alida M. Bouatta, Xin Wang, Marjorie Guichard, Robertas Ursache, Hugo Tavares, Kevin Verstaen, Jos Wendrich, Charles W. Melnyk, Yoshihisa Oda, Dennis Shasha, Sebastian E. Ahnert, Yvan Saeys, Bert De Rybel, Renze Heidstra, Ben Scheres, Guido Grossmann, Ari Pekka Mähönen, Philipp Denninger, Berthold Göttgens, Rosangela Sozzani, Kenneth D. Birnbaum, and Yrjö Helariutta. 2021. “Cell-by-Cell Dissection of Phloem Development Links a Maturation Gradient to Cell Specialization.” SCIENCE 374 (6575). doi:10.1126/science.aba5531.
Vancouver
1.
Roszak P, Heo J, Blob B, Toyokura K, Sugiyama Y, de Luis Balaguer MA, et al. Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization. SCIENCE. 2021;374(6575).
IEEE
[1]
P. Roszak et al., “Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization,” SCIENCE, vol. 374, no. 6575, 2021.
@article{8733113,
  abstract     = {{In the plant meristem, tissue-wide maturation gradients are coordinated with specialized cell networks to establish various developmental phases required for indeterminate growth. Here, we used single-cell transcriptomics to reconstruct the protophloem developmental trajectory from the birth of cell progenitors to terminal differentiation in the Arabidopsis thaliana root. PHLOEM EARLY DNA-BINDING WITH-ONE-FINGER (PEAR) transcription factors mediate lineage bifurcation by activating guanosine triphosphatase signaling and prime a transcriptional differentiation program. This program is initially repressed by a meristem-wide gradient of PLETHORA transcription factors. Only the dissipation of PLETHORA gradient permits activation of the differentiation program that involves mutual inhibition of early versus late meristem regulators. Thus, for phloem development, broad maturation gradients interface with cell-type-specific transcriptional regulators to stage cellular differentiation}},
  articleno    = {{eaba5531}},
  author       = {{Roszak, Pawel and Heo, Jung-ok and Blob, Bernhard and Toyokura, Koichi and Sugiyama, Yuki and de Luis Balaguer, Maria Angels and Lau, Winnie W. Y. and Hamey, Fiona and Cirrone, Jacopo and Madej, Ewelina and Bouatta, Alida M. and Wang, Xin and Guichard, Marjorie and Ursache, Robertas and Tavares, Hugo and Verstaen, Kevin and Wendrich, Jos and Melnyk, Charles W. and Oda, Yoshihisa and Shasha, Dennis and Ahnert, Sebastian E. and Saeys, Yvan and De Rybel, Bert and Heidstra, Renze and Scheres, Ben and Grossmann, Guido and Mähönen, Ari Pekka and Denninger, Philipp and Göttgens, Berthold and Sozzani, Rosangela and Birnbaum, Kenneth D. and Helariutta, Yrjö}},
  issn         = {{0036-8075}},
  journal      = {{SCIENCE}},
  keywords     = {{Multidisciplinary,REGULATORY NETWORK,RNA-SEQ,ROOT,GTPASES,GROWTH,GENE,MORPHOGENESIS,REVEALS,RHO,EXPRESSION}},
  language     = {{eng}},
  number       = {{6575}},
  pages        = {{9}},
  title        = {{Cell-by-cell dissection of phloem development links a maturation gradient to cell specialization}},
  url          = {{http://doi.org/10.1126/science.aba5531}},
  volume       = {{374}},
  year         = {{2021}},
}
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