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Novel alkaloids from marine actinobacteria : discovery and characterization

Anne-Sofie De Rop (UGent) , Jeltien Rombaut (UGent) , Thomas Willems (UGent) , Marilyn De Graeve (UGent) , Lynn Vanhaecke (UGent) , Paco Hulpiau, Sofie De Maeseneire (UGent) , Maarten De Mol (UGent) and Wim Soetaert (UGent)
(2021) MARINE DRUGS. 20(1).
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Abstract
The marine environment is an excellent resource for natural products with therapeutic potential. Its microbial inhabitants, often associated with other marine organisms, are specialized in the synthesis of bioactive secondary metabolites. Similar to their terrestrial counterparts, marine Actinobacteria are a prevalent source of these natural products. Here, we discuss 77 newly discovered alkaloids produced by such marine Actinobacteria between 2017 and mid-2021, as well as the strategies employed in their elucidation. While 12 different classes of alkaloids were unraveled, indoles, diketopiperazines, glutarimides, indolizidines, and pyrroles were most dominant. Discoveries were mainly based on experimental approaches where microbial extracts were analyzed in relation to novel compounds. Although such experimental procedures have proven useful in the past, the methodologies need adaptations to limit the chance of compound rediscovery. On the other hand, genome mining provides a different angle for natural product discovery. While the technology is still relatively young compared to experimental screening, significant improvement has been made in recent years. Together with synthetic biology tools, both genome mining and extract screening provide excellent opportunities for continued drug discovery from marine Actinobacteria.
Keywords
marine Actinobacteria, alkaloids, chemical structure elucidation, genome mining, synthetic biology, biosynthesis, BIOSYNTHETIC GENE CLUSTERS, NATURAL-PRODUCTS, GENOME ANNOTATION, IDENTIFICATION, DERIVATIVES, METABOLISM, TOOLS

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Citation

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MLA
De Rop, Anne-Sofie, et al. “Novel Alkaloids from Marine Actinobacteria : Discovery and Characterization.” MARINE DRUGS, vol. 20, no. 1, 2021, doi:10.3390/md20010006.
APA
De Rop, A.-S., Rombaut, J., Willems, T., De Graeve, M., Vanhaecke, L., Hulpiau, P., … Soetaert, W. (2021). Novel alkaloids from marine actinobacteria : discovery and characterization. MARINE DRUGS, 20(1). https://doi.org/10.3390/md20010006
Chicago author-date
De Rop, Anne-Sofie, Jeltien Rombaut, Thomas Willems, Marilyn De Graeve, Lynn Vanhaecke, Paco Hulpiau, Sofie De Maeseneire, Maarten De Mol, and Wim Soetaert. 2021. “Novel Alkaloids from Marine Actinobacteria : Discovery and Characterization.” MARINE DRUGS 20 (1). https://doi.org/10.3390/md20010006.
Chicago author-date (all authors)
De Rop, Anne-Sofie, Jeltien Rombaut, Thomas Willems, Marilyn De Graeve, Lynn Vanhaecke, Paco Hulpiau, Sofie De Maeseneire, Maarten De Mol, and Wim Soetaert. 2021. “Novel Alkaloids from Marine Actinobacteria : Discovery and Characterization.” MARINE DRUGS 20 (1). doi:10.3390/md20010006.
Vancouver
1.
De Rop A-S, Rombaut J, Willems T, De Graeve M, Vanhaecke L, Hulpiau P, et al. Novel alkaloids from marine actinobacteria : discovery and characterization. MARINE DRUGS. 2021;20(1).
IEEE
[1]
A.-S. De Rop et al., “Novel alkaloids from marine actinobacteria : discovery and characterization,” MARINE DRUGS, vol. 20, no. 1, 2021.
@article{8732985,
  abstract     = {{The marine environment is an excellent resource for natural products with therapeutic potential. Its microbial inhabitants, often associated with other marine organisms, are specialized in the synthesis of bioactive secondary metabolites. Similar to their terrestrial counterparts, marine Actinobacteria are a prevalent source of these natural products. Here, we discuss 77 newly discovered alkaloids produced by such marine Actinobacteria between 2017 and mid-2021, as well as the strategies employed in their elucidation. While 12 different classes of alkaloids were unraveled, indoles, diketopiperazines, glutarimides, indolizidines, and pyrroles were most dominant. Discoveries were mainly based on experimental approaches where microbial extracts were analyzed in relation to novel compounds. Although such experimental procedures have proven useful in the past, the methodologies need adaptations to limit the chance of compound rediscovery. On the other hand, genome mining provides a different angle for natural product discovery. While the technology is still relatively young compared to experimental screening, significant improvement has been made in recent years. Together with synthetic biology tools, both genome mining and extract screening provide excellent opportunities for continued drug discovery from marine Actinobacteria.}},
  articleno    = {{6}},
  author       = {{De Rop, Anne-Sofie and Rombaut, Jeltien and Willems, Thomas and De Graeve, Marilyn and Vanhaecke, Lynn and Hulpiau, Paco and De Maeseneire, Sofie and De Mol, Maarten and Soetaert, Wim}},
  issn         = {{1660-3397}},
  journal      = {{MARINE DRUGS}},
  keywords     = {{marine Actinobacteria,alkaloids,chemical structure elucidation,genome mining,synthetic biology,biosynthesis,BIOSYNTHETIC GENE CLUSTERS,NATURAL-PRODUCTS,GENOME ANNOTATION,IDENTIFICATION,DERIVATIVES,METABOLISM,TOOLS}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{23}},
  title        = {{Novel alkaloids from marine actinobacteria : discovery and characterization}},
  url          = {{http://doi.org/10.3390/md20010006}},
  volume       = {{20}},
  year         = {{2021}},
}
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