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Saving time by replacing the standardised two-hour oral glucose tolerance test with a one-hour test : validation of a new screening algorithm in patients with coronary artery disease from the ESC-EORP EUROASPIRE V registry

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Abstract
Aims: An oral glucose tolerance test (OGTT) combining fasting (FPG) and 2-hour plasma glucose (2hPG) is the most sensitive method for detecting type 2 diabetes (T2DM). Since it is considered time-consuming, we aim at validating a previously proposed screening algorithm based on a 1-hour plasma glucose (1hPG) with a 12 mmol/L threshold. Methods: Nine-hundred-eighteen patients with coronary artery disease (CAD) without known T2DM from the EUROASPIRE V cross-sectional survey underwent an OGTT. The reference for T2DM was 2hPG > 11.1 mmol/L. T2DM diagnosis by HbA1c > 6.5%(48 mmol/mol), FPG > 7.0 mmol/L, and 1hPG > 12 mmol/L were compared with the outcome of 2hPG. Results: Mean FPG, HbA1c and 2hPG were 6.1 mmol/L, 5.6%(38 mmol/mol) and 7.8 mmol/L respectively. Ninety-six patients (10%) were diagnosed with T2DM according to 2hPG. Using this definition, in the group with FPG < 6.5 mmol/L and 1hPG < 12 only 5 (1%) were misdiagnosed as false negatives. All patients with a FPG > 8.0 mmol/L and 1hPG > 15.0 mmol/L were identified as having T2DM. According to the algorithm, in 79% of patients T2DM could be excluded by combining FPG < 6.5 mmol/L and 1hPG < 12 mmol/L. Conclusions: T2DM Screening by means of an algorithm combining FPG and 1hPG limits the demand of a 2hOGTT in 79% of CAD patients without known T2DM. HbA1c did not add to the information derived from this algorithm. (c) 2021 Published by Elsevier B.V.
Keywords
Endocrinology, General Medicine, Endocrinology, Diabetes and Metabolism, Internal Medicine, Screening, Diagnosis, OGTT, Coronary Artery Disease, Ischemic Heart Disease, Survey, Prevention, ACUTE MYOCARDIAL-INFARCTION, POSTLOAD PLASMA-GLUCOSE, EUROPEAN-SOCIETY, CARDIOVASCULAR-DISEASE, INSULIN-RESISTANCE, DIABETES-MELLITUS, RISK, MORTALITY, MANAGEMENT, HEART

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MLA
Ferrannini, Giulia, et al. “Saving Time by Replacing the Standardised Two-Hour Oral Glucose Tolerance Test with a One-Hour Test : Validation of a New Screening Algorithm in Patients with Coronary Artery Disease from the ESC-EORP EUROASPIRE V Registry.” DIABETES RESEARCH AND CLINICAL PRACTICE, vol. 183, 2021, doi:10.1016/j.diabres.2021.109156.
APA
Ferrannini, G., De Bacquer, D., Gyberg, V., De Backer, G., Kotseva, K., Mellbin, L. G., … Rydén, L. (2021). Saving time by replacing the standardised two-hour oral glucose tolerance test with a one-hour test : validation of a new screening algorithm in patients with coronary artery disease from the ESC-EORP EUROASPIRE V registry. DIABETES RESEARCH AND CLINICAL PRACTICE, 183. https://doi.org/10.1016/j.diabres.2021.109156
Chicago author-date
Ferrannini, Giulia, Dirk De Bacquer, Viveca Gyberg, Gui De Backer, Kornelia Kotseva, Linda G Mellbin, Rebecca Risebrink, Jaakko Tuomilehto, David Wood, and Lars Rydén. 2021. “Saving Time by Replacing the Standardised Two-Hour Oral Glucose Tolerance Test with a One-Hour Test : Validation of a New Screening Algorithm in Patients with Coronary Artery Disease from the ESC-EORP EUROASPIRE V Registry.” DIABETES RESEARCH AND CLINICAL PRACTICE 183. https://doi.org/10.1016/j.diabres.2021.109156.
Chicago author-date (all authors)
Ferrannini, Giulia, Dirk De Bacquer, Viveca Gyberg, Gui De Backer, Kornelia Kotseva, Linda G Mellbin, Rebecca Risebrink, Jaakko Tuomilehto, David Wood, and Lars Rydén. 2021. “Saving Time by Replacing the Standardised Two-Hour Oral Glucose Tolerance Test with a One-Hour Test : Validation of a New Screening Algorithm in Patients with Coronary Artery Disease from the ESC-EORP EUROASPIRE V Registry.” DIABETES RESEARCH AND CLINICAL PRACTICE 183. doi:10.1016/j.diabres.2021.109156.
Vancouver
1.
Ferrannini G, De Bacquer D, Gyberg V, De Backer G, Kotseva K, Mellbin LG, et al. Saving time by replacing the standardised two-hour oral glucose tolerance test with a one-hour test : validation of a new screening algorithm in patients with coronary artery disease from the ESC-EORP EUROASPIRE V registry. DIABETES RESEARCH AND CLINICAL PRACTICE. 2021;183.
IEEE
[1]
G. Ferrannini et al., “Saving time by replacing the standardised two-hour oral glucose tolerance test with a one-hour test : validation of a new screening algorithm in patients with coronary artery disease from the ESC-EORP EUROASPIRE V registry,” DIABETES RESEARCH AND CLINICAL PRACTICE, vol. 183, 2021.
@article{8732382,
  abstract     = {{Aims: An oral glucose tolerance test (OGTT) combining fasting (FPG) and 2-hour plasma glucose (2hPG) is the most sensitive method for detecting type 2 diabetes (T2DM). Since it is considered time-consuming, we aim at validating a previously proposed screening algorithm based on a 1-hour plasma glucose (1hPG) with a 12 mmol/L threshold. Methods: Nine-hundred-eighteen patients with coronary artery disease (CAD) without known T2DM from the EUROASPIRE V cross-sectional survey underwent an OGTT. The reference for T2DM was 2hPG > 11.1 mmol/L. T2DM diagnosis by HbA1c > 6.5%(48 mmol/mol), FPG > 7.0 mmol/L, and 1hPG > 12 mmol/L were compared with the outcome of 2hPG. Results: Mean FPG, HbA1c and 2hPG were 6.1 mmol/L, 5.6%(38 mmol/mol) and 7.8 mmol/L respectively. Ninety-six patients (10%) were diagnosed with T2DM according to 2hPG. Using this definition, in the group with FPG < 6.5 mmol/L and 1hPG < 12 only 5 (1%) were misdiagnosed as false negatives. All patients with a FPG > 8.0 mmol/L and 1hPG > 15.0 mmol/L were identified as having T2DM. According to the algorithm, in 79% of patients T2DM could be excluded by combining FPG < 6.5 mmol/L and 1hPG < 12 mmol/L. Conclusions: T2DM Screening by means of an algorithm combining FPG and 1hPG limits the demand of a 2hOGTT in 79% of CAD patients without known T2DM. HbA1c did not add to the information derived from this algorithm. (c) 2021 Published by Elsevier B.V.}},
  articleno    = {{109156}},
  author       = {{Ferrannini, Giulia and De Bacquer, Dirk and Gyberg, Viveca and De Backer, Gui and Kotseva, Kornelia and Mellbin, Linda G and Risebrink, Rebecca and Tuomilehto, Jaakko and Wood, David and Rydén, Lars}},
  issn         = {{0168-8227}},
  journal      = {{DIABETES RESEARCH AND CLINICAL PRACTICE}},
  keywords     = {{Endocrinology,General Medicine,Endocrinology,Diabetes and Metabolism,Internal Medicine,Screening,Diagnosis,OGTT,Coronary Artery Disease,Ischemic Heart Disease,Survey,Prevention,ACUTE MYOCARDIAL-INFARCTION,POSTLOAD PLASMA-GLUCOSE,EUROPEAN-SOCIETY,CARDIOVASCULAR-DISEASE,INSULIN-RESISTANCE,DIABETES-MELLITUS,RISK,MORTALITY,MANAGEMENT,HEART}},
  language     = {{eng}},
  pages        = {{8}},
  title        = {{Saving time by replacing the standardised two-hour oral glucose tolerance test with a one-hour test : validation of a new screening algorithm in patients with coronary artery disease from the ESC-EORP EUROASPIRE V registry}},
  url          = {{http://dx.doi.org/10.1016/j.diabres.2021.109156}},
  volume       = {{183}},
  year         = {{2021}},
}

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