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Urinary polycyclic aromatic hydrocarbon metabolites are associated with biomarkers of chronic endocrine stress, oxidative stress, and inflammation in adolescents : FLEHS-4 (2016–2020)

Veerle J. Verheyen, Sylvie Remy, Eva Govarts, Ann Colles, Laura Rodriguez Martin, Gudrun Koppen, Stefan Voorspoels, Liesbeth Bruckers, Esmée M. Bijnens, Stijn Vos, et al.
(2021) TOXICS. 9(10).
Author
Organization
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants of public health concern. Multiple biological mechanisms have been hypothesized to contribute to PAHs-associated adverse health effects. Little is known about the impact of PAHs on endocrine stress and inflammation in adolescence. We examined 393 Flemish adolescents (14–15 years) cross-sectionally, measured urinary concentrations of hydroxylated naphthalene, fluorene, phenanthrene and pyrene metabolites, and calculated the sum of all measured metabolites. We determined hair cortisol concentration (HCC) as endocrine stress biomarker, leucocyte counts and neutrophil–lymphocyte ratio (NLR) in peripheral blood as inflammatory biomarkers, and urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) concentration as oxidative stress biomarker. Exposure–response associations were analyzed by multiple regression, adjusted for a priori selected covariates. A doubling of 1-hydroxypyrene concentration was associated with a factor of 1.13 (95% CI: 1.03, 1.24) increase in HCC and a factor of 1.07 (95% CI: 1.02, 1.13) increase in 8-oxodG. Doublings of 2- and 3-hydroxyphenanthrene concentrations were associated with a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.00, 1.12) increase in 8-oxodG, respectively. Doubling of 2-hydroxyphenanthrene and of the sum of 2- and 3-hydroxyfluorene was associated with, respectively, a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.01, 1.13) increase in NLR. Our results indicate the glucocorticoid pathway as a potential target for PAH exposure in adolescents and suggest oxidative stress, endocrine stress, and inflammation in adolescence as underlying mechanisms and early markers for PAH-related adverse health effects.
Keywords
Chemical Health and Safety, Health, Toxicology and Mutagenesis, Toxicology, adolescents, human biomonitoring, Flemish Environment and Health Study (FLEHS), polycyclic aromatic hydrocarbons, hair cortisol concentration, neutrophil-lymphocyte ratio, 8-oxo-7, 8-dihydro-2-deoxyguanosine

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MLA
Verheyen, Veerle J., et al. “Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents : FLEHS-4 (2016–2020).” TOXICS, vol. 9, no. 10, 2021, doi:10.3390/toxics9100245.
APA
Verheyen, V. J., Remy, S., Govarts, E., Colles, A., Rodriguez Martin, L., Koppen, G., … Schoeters, G. (2021). Urinary polycyclic aromatic hydrocarbon metabolites are associated with biomarkers of chronic endocrine stress, oxidative stress, and inflammation in adolescents : FLEHS-4 (2016–2020). TOXICS, 9(10). https://doi.org/10.3390/toxics9100245
Chicago author-date
Verheyen, Veerle J., Sylvie Remy, Eva Govarts, Ann Colles, Laura Rodriguez Martin, Gudrun Koppen, Stefan Voorspoels, et al. 2021. “Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents : FLEHS-4 (2016–2020).” TOXICS 9 (10). https://doi.org/10.3390/toxics9100245.
Chicago author-date (all authors)
Verheyen, Veerle J., Sylvie Remy, Eva Govarts, Ann Colles, Laura Rodriguez Martin, Gudrun Koppen, Stefan Voorspoels, Liesbeth Bruckers, Esmée M. Bijnens, Stijn Vos, Bert Morrens, Dries Coertjens, Annelies De Decker, Carmen Franken, Elly Den Hond, Vera Nelen, Adrian Covaci, Ilse Loots, Stefaan De Henauw, Nicolas Van Larebeke, Caroline Teughels, Tim S. Nawrot, and Greet Schoeters. 2021. “Urinary Polycyclic Aromatic Hydrocarbon Metabolites Are Associated with Biomarkers of Chronic Endocrine Stress, Oxidative Stress, and Inflammation in Adolescents : FLEHS-4 (2016–2020).” TOXICS 9 (10). doi:10.3390/toxics9100245.
Vancouver
1.
Verheyen VJ, Remy S, Govarts E, Colles A, Rodriguez Martin L, Koppen G, et al. Urinary polycyclic aromatic hydrocarbon metabolites are associated with biomarkers of chronic endocrine stress, oxidative stress, and inflammation in adolescents : FLEHS-4 (2016–2020). TOXICS. 2021;9(10).
IEEE
[1]
V. J. Verheyen et al., “Urinary polycyclic aromatic hydrocarbon metabolites are associated with biomarkers of chronic endocrine stress, oxidative stress, and inflammation in adolescents : FLEHS-4 (2016–2020),” TOXICS, vol. 9, no. 10, 2021.
@article{8731233,
  abstract     = {{Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants of public health concern. Multiple biological mechanisms have been hypothesized to contribute to PAHs-associated adverse health effects. Little is known about the impact of PAHs on endocrine stress and inflammation in adolescence. We examined 393 Flemish adolescents (14–15 years) cross-sectionally, measured urinary concentrations of hydroxylated naphthalene, fluorene, phenanthrene and pyrene metabolites, and calculated the sum of all measured metabolites. We determined hair cortisol concentration (HCC) as endocrine stress biomarker, leucocyte counts and neutrophil–lymphocyte ratio (NLR) in peripheral blood as inflammatory biomarkers, and urinary 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG) concentration as oxidative stress biomarker. Exposure–response associations were analyzed by multiple regression, adjusted for a priori selected covariates. A doubling of 1-hydroxypyrene concentration was associated with a factor of 1.13 (95% CI: 1.03, 1.24) increase in HCC and a factor of 1.07 (95% CI: 1.02, 1.13) increase in 8-oxodG. Doublings of 2- and 3-hydroxyphenanthrene concentrations were associated with a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.00, 1.12) increase in 8-oxodG, respectively. Doubling of 2-hydroxyphenanthrene and of the sum of 2- and 3-hydroxyfluorene was associated with, respectively, a factor of 1.08 (95% CI: 1.02, 1.14) and 1.06 (95% CI: 1.01, 1.13) increase in NLR. Our results indicate the glucocorticoid pathway as a potential target for PAH exposure in adolescents and suggest oxidative stress, endocrine stress, and inflammation in adolescence as underlying mechanisms and early markers for PAH-related adverse health effects.}},
  articleno    = {{245}},
  author       = {{Verheyen, Veerle J. and Remy, Sylvie and Govarts, Eva and Colles, Ann and Rodriguez Martin, Laura and Koppen, Gudrun and Voorspoels, Stefan and Bruckers, Liesbeth and Bijnens, Esmée M. and Vos, Stijn and Morrens, Bert and Coertjens, Dries and De Decker, Annelies and Franken, Carmen and Den Hond, Elly and Nelen, Vera and Covaci, Adrian and Loots, Ilse and De Henauw, Stefaan and Van Larebeke, Nicolas and Teughels, Caroline and Nawrot, Tim S. and Schoeters, Greet}},
  issn         = {{2305-6304}},
  journal      = {{TOXICS}},
  keywords     = {{Chemical Health and Safety,Health,Toxicology and Mutagenesis,Toxicology,adolescents,human biomonitoring,Flemish Environment and Health Study (FLEHS),polycyclic aromatic hydrocarbons,hair cortisol concentration,neutrophil-lymphocyte ratio,8-oxo-7,8-dihydro-2-deoxyguanosine}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{21}},
  title        = {{Urinary polycyclic aromatic hydrocarbon metabolites are associated with biomarkers of chronic endocrine stress, oxidative stress, and inflammation in adolescents : FLEHS-4 (2016–2020)}},
  url          = {{http://doi.org/10.3390/toxics9100245}},
  volume       = {{9}},
  year         = {{2021}},
}
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