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Association of desaturase activity and C-reactive protein in European children

Maike Wolters, Claudia Boernhorst, Heike Schwarz, Patrizia Rise, Claudio Galli, Luis A. Moreno, Valeria Pala, Paola Russo, Toomas Veidebaum, Michael Tornaritis, et al.
(2017) PEDIATRIC RESEARCH. 81(1). p.27-32
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Abstract
BACKGROUND: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high sensitive C-reactive protein (CRP) in young children. METHODS: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (TO) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from TO product-precursor FA ratios. CRP was measured at TO and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. RESULTS: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. CONCLUSION: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.
Keywords
STEAROYL-COA DESATURASE, FATTY-ACID-COMPOSITION, INSULIN-RESISTANCE, PALMITOLEIC ACID, INFLAMMATION, OBESITY, MEN, IDEFICS, SENSITIVITY, POPULATION

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MLA
Wolters, Maike, et al. “Association of Desaturase Activity and C-Reactive Protein in European Children.” PEDIATRIC RESEARCH, vol. 81, no. 1, 2017, pp. 27–32, doi:10.1038/pr.2016.186.
APA
Wolters, M., Boernhorst, C., Schwarz, H., Rise, P., Galli, C., Moreno, L. A., … Ahrens, W. (2017). Association of desaturase activity and C-reactive protein in European children. PEDIATRIC RESEARCH, 81(1), 27–32. https://doi.org/10.1038/pr.2016.186
Chicago author-date
Wolters, Maike, Claudia Boernhorst, Heike Schwarz, Patrizia Rise, Claudio Galli, Luis A. Moreno, Valeria Pala, et al. 2017. “Association of Desaturase Activity and C-Reactive Protein in European Children.” PEDIATRIC RESEARCH 81 (1): 27–32. https://doi.org/10.1038/pr.2016.186.
Chicago author-date (all authors)
Wolters, Maike, Claudia Boernhorst, Heike Schwarz, Patrizia Rise, Claudio Galli, Luis A. Moreno, Valeria Pala, Paola Russo, Toomas Veidebaum, Michael Tornaritis, Arno Fraterman, Stefaan De Henauw, Gabriele Eiben, Lauren Lissner, Denes Molnar, and Wolfgang Ahrens. 2017. “Association of Desaturase Activity and C-Reactive Protein in European Children.” PEDIATRIC RESEARCH 81 (1): 27–32. doi:10.1038/pr.2016.186.
Vancouver
1.
Wolters M, Boernhorst C, Schwarz H, Rise P, Galli C, Moreno LA, et al. Association of desaturase activity and C-reactive protein in European children. PEDIATRIC RESEARCH. 2017;81(1):27–32.
IEEE
[1]
M. Wolters et al., “Association of desaturase activity and C-reactive protein in European children,” PEDIATRIC RESEARCH, vol. 81, no. 1, pp. 27–32, 2017.
@article{8731216,
  abstract     = {{BACKGROUND: Desaturase enzymes influence the fatty acid (FA) composition of body tissues and their activity affects the conversion rate of saturated to monounsaturated FA and of polyunsaturated FA (PUFA) to long-chain PUFA. Desaturase activity has further been shown to be associated with inflammation. We investigate the association between delta-9 (D9D), delta-6 (D6D) and delta-5 desaturase (D5D) activity and high sensitive C-reactive protein (CRP) in young children. METHODS: In the IDEFICS (Identification and prevention of dietary- and lifestyle-induced health effects in children and infants) cohort study children were examined at baseline (TO) and after 2 y (T1). D9D, D6D, and D5D activities were estimated from TO product-precursor FA ratios. CRP was measured at TO and T1. In a subsample of 1,943 children with available information on FA, CRP, and covariates, the cross-sectional and longitudinal associations of desaturase activity and CRP were analyzed. RESULTS: Cross-sectionally, a D9D increase of 0.01 units was associated with a 11% higher risk of having a serum CRP Percentile 75 (P75) (OR, 99% CI: 1.11 (1.01; 1.22)) whereas D6D and D5D were not associated with CRP. No significant associations were observed between baseline desaturase activity and CRP 2 y later. CONCLUSION: Cross-sectionally, our results indicate a positive association of D9D and CRP independent of weight status. High D9D activity may increase the risk of subclinical inflammation which is associated with metabolic disorders. As D9D expression increases with higher intake of saturated FA and carbohydrates, dietary changes may influence D9D activity and thus CRP. However, it remains to be investigated whether there is a causal relationship between D9D activity and CRP.}},
  author       = {{Wolters, Maike and Boernhorst, Claudia and Schwarz, Heike and Rise, Patrizia and Galli, Claudio and Moreno, Luis A. and Pala, Valeria and Russo, Paola and Veidebaum, Toomas and Tornaritis, Michael and Fraterman, Arno and De Henauw, Stefaan and Eiben, Gabriele and Lissner, Lauren and Molnar, Denes and Ahrens, Wolfgang}},
  issn         = {{0031-3998}},
  journal      = {{PEDIATRIC RESEARCH}},
  keywords     = {{STEAROYL-COA DESATURASE,FATTY-ACID-COMPOSITION,INSULIN-RESISTANCE,PALMITOLEIC ACID,INFLAMMATION,OBESITY,MEN,IDEFICS,SENSITIVITY,POPULATION}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{27--32}},
  title        = {{Association of desaturase activity and C-reactive protein in European children}},
  url          = {{http://doi.org/10.1038/pr.2016.186}},
  volume       = {{81}},
  year         = {{2017}},
}
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