Gas-shearing synthesis of core–shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction
- Author
- Qingli Qu, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Jian Zhang, Yankang Deng, Kevin Braeckmans (UGent) , Stefaan De Smedt (UGent) , Ranhua Xiong and Chaobo Huang
- Organization
- Abstract
- Core-shell multicompartmental microparticles have gained increasing attention as their architecture resembles the multicompartmental composition of eukaryotic cells. However, challenges remain in the fabrication of biocompatible multicompartmental microparticles at a sufficiently high scale. Herein, all-aqueous 'mangosteenlike' core-shell multicompartmental microparticles were created by an oil-free gas-shearing fabrication approach. Both the shell thickness and core size of thus obtained mangosteen-like microparticles can be easily finetuned. Mangosteen-like particles have well segregated (up to eight) compartments which are attractive to precisely control enzymatic cascade reactions. To illustrate the application potential, insulin releasing mangosteen-like microparticles ('artificial pancreatic beta cells') were developed.
- Keywords
- Gas-shearing fabrication, Core-shell multicompartmental microparticles, Mangosteen-like microparticles, Artificial cells, Enzymatic cascade reaction, HYDROGEL, RELEASE
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-8730011
- MLA
- Qu, Qingli, et al. “Gas-Shearing Synthesis of Core–Shell Multicompartmental Microparticles as Cell-like System for Enzymatic Cascade Reaction.” CHEMICAL ENGINEERING JOURNAL, vol. 428, 2022, doi:10.1016/j.cej.2021.132607.
- APA
- Qu, Q., Zhang, X., Ravanbakhsh, H., Tang, G., Zhang, J., Deng, Y., … Huang, C. (2022). Gas-shearing synthesis of core–shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction. CHEMICAL ENGINEERING JOURNAL, 428. https://doi.org/10.1016/j.cej.2021.132607
- Chicago author-date
- Qu, Qingli, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Jian Zhang, Yankang Deng, Kevin Braeckmans, Stefaan De Smedt, Ranhua Xiong, and Chaobo Huang. 2022. “Gas-Shearing Synthesis of Core–Shell Multicompartmental Microparticles as Cell-like System for Enzymatic Cascade Reaction.” CHEMICAL ENGINEERING JOURNAL 428. https://doi.org/10.1016/j.cej.2021.132607.
- Chicago author-date (all authors)
- Qu, Qingli, Xiaoli Zhang, Hossein Ravanbakhsh, Guosheng Tang, Jian Zhang, Yankang Deng, Kevin Braeckmans, Stefaan De Smedt, Ranhua Xiong, and Chaobo Huang. 2022. “Gas-Shearing Synthesis of Core–Shell Multicompartmental Microparticles as Cell-like System for Enzymatic Cascade Reaction.” CHEMICAL ENGINEERING JOURNAL 428. doi:10.1016/j.cej.2021.132607.
- Vancouver
- 1.Qu Q, Zhang X, Ravanbakhsh H, Tang G, Zhang J, Deng Y, et al. Gas-shearing synthesis of core–shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction. CHEMICAL ENGINEERING JOURNAL. 2022;428.
- IEEE
- [1]Q. Qu et al., “Gas-shearing synthesis of core–shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction,” CHEMICAL ENGINEERING JOURNAL, vol. 428, 2022.
@article{8730011,
abstract = {{Core-shell multicompartmental microparticles have gained increasing attention as their architecture resembles the multicompartmental composition of eukaryotic cells. However, challenges remain in the fabrication of biocompatible multicompartmental microparticles at a sufficiently high scale. Herein, all-aqueous 'mangosteenlike' core-shell multicompartmental microparticles were created by an oil-free gas-shearing fabrication approach. Both the shell thickness and core size of thus obtained mangosteen-like microparticles can be easily finetuned. Mangosteen-like particles have well segregated (up to eight) compartments which are attractive to precisely control enzymatic cascade reactions. To illustrate the application potential, insulin releasing mangosteen-like microparticles ('artificial pancreatic beta cells') were developed.}},
articleno = {{132607}},
author = {{Qu, Qingli and Zhang, Xiaoli and Ravanbakhsh, Hossein and Tang, Guosheng and Zhang, Jian and Deng, Yankang and Braeckmans, Kevin and De Smedt, Stefaan and Xiong, Ranhua and Huang, Chaobo}},
issn = {{1385-8947}},
journal = {{CHEMICAL ENGINEERING JOURNAL}},
keywords = {{Gas-shearing fabrication,Core-shell multicompartmental microparticles,Mangosteen-like microparticles,Artificial cells,Enzymatic cascade reaction,HYDROGEL,RELEASE}},
language = {{eng}},
pages = {{8}},
title = {{Gas-shearing synthesis of core–shell multicompartmental microparticles as cell-like system for enzymatic cascade reaction}},
url = {{http://dx.doi.org/10.1016/j.cej.2021.132607}},
volume = {{428}},
year = {{2022}},
}
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