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Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology

Jana Ramon (UGent) , Ranhua Xiong, Stefaan De Smedt (UGent) , Koen Raemdonck (UGent) and Kevin Braeckmans (UGent)
(2021) CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. 54.
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Abstract
Vapor nanobubble-mediated photoporation has evolved into a promising physical intracellular delivery technology. When irradiated with short but intense laser pulses, photothermal nanomaterials can generate vapor nanobubbles that, when they collapse, induce transient membrane pores through which exogenous effector molecules can be delivered into the cells. Interestingly, this technique offers high-throughput delivery in various cell types, including hard-to-transfect primary cells. A unique feature among cell transfection technologies is its ability to deliver compounds in spatially defined areas, even with single-cell resolution, through controlled scanning of the laser beam. This is especially useful for targeting specific cells in dense heterogenous samples. Although primarily used for permeabilizing the outer cell membrane, this strategy has been exploited to destabilize endosomal and nuclear membranes as well.
Keywords
Vapor nanobubbles, Photoporation, Laser, Gold nanoparticles, Carbon nanomaterials, Photothermal substrates, Membrane disruption, Intracellular delivery, Cell-selective delivery, Photothermal&nbsp, nanoparticles, ULTRAFAST LASER, GOLD NANOPARTICLES, CELLS, TRANSFECTION, EFFICIENT, MACROMOLECULES, FUNDAMENTALS, OPTOPORATION, IRRADIATION, GENERATION

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Citation

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MLA
Ramon, Jana, et al. “Vapor Nanobubble-Mediated Photoporation Constitutes a Versatile Intracellular Delivery Technology.” CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, edited by Jana Ramon, vol. 54, 2021, doi:10.1016/j.cocis.2021.101453.
APA
Ramon, J., Xiong, R., De Smedt, S., Raemdonck, K., & Braeckmans, K. (2021). Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, 54. https://doi.org/10.1016/j.cocis.2021.101453
Chicago author-date
Ramon, Jana, Ranhua Xiong, Stefaan De Smedt, Koen Raemdonck, and Kevin Braeckmans. 2021. “Vapor Nanobubble-Mediated Photoporation Constitutes a Versatile Intracellular Delivery Technology.” Edited by Jana Ramon. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE 54. https://doi.org/10.1016/j.cocis.2021.101453.
Chicago author-date (all authors)
Ramon, Jana, Ranhua Xiong, Stefaan De Smedt, Koen Raemdonck, and Kevin Braeckmans. 2021. “Vapor Nanobubble-Mediated Photoporation Constitutes a Versatile Intracellular Delivery Technology.” Ed by. Jana Ramon. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE 54. doi:10.1016/j.cocis.2021.101453.
Vancouver
1.
Ramon J, Xiong R, De Smedt S, Raemdonck K, Braeckmans K. Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology. Ramon J, editor. CURRENT OPINION IN COLLOID & INTERFACE SCIENCE. 2021;54.
IEEE
[1]
J. Ramon, R. Xiong, S. De Smedt, K. Raemdonck, and K. Braeckmans, “Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology,” CURRENT OPINION IN COLLOID & INTERFACE SCIENCE, vol. 54, 2021.
@article{8729987,
  abstract     = {{Vapor nanobubble-mediated photoporation has evolved into a promising physical intracellular delivery technology. When irradiated with short but intense laser pulses, photothermal nanomaterials can generate vapor nanobubbles that, when they collapse, induce transient membrane pores through which exogenous effector molecules can be delivered into the cells. Interestingly, this technique offers high-throughput delivery in various cell types, including hard-to-transfect primary cells. A unique feature among cell transfection technologies is its ability to deliver compounds in spatially defined areas, even with single-cell resolution, through controlled scanning of the laser beam. This is especially useful for targeting specific cells in dense heterogenous samples. Although primarily used for permeabilizing the outer cell membrane, this strategy has been exploited to destabilize endosomal and nuclear membranes as well.}},
  articleno    = {{101453}},
  author       = {{Ramon, Jana and Xiong, Ranhua and De Smedt, Stefaan and Raemdonck, Koen and Braeckmans, Kevin}},
  editor       = {{Ramon, Jana}},
  issn         = {{1359-0294}},
  journal      = {{CURRENT OPINION IN COLLOID & INTERFACE SCIENCE}},
  keywords     = {{Vapor nanobubbles,Photoporation,Laser,Gold nanoparticles,Carbon nanomaterials,Photothermal substrates,Membrane disruption,Intracellular delivery,Cell-selective delivery,Photothermal&nbsp,nanoparticles,ULTRAFAST LASER,GOLD NANOPARTICLES,CELLS,TRANSFECTION,EFFICIENT,MACROMOLECULES,FUNDAMENTALS,OPTOPORATION,IRRADIATION,GENERATION}},
  language     = {{eng}},
  pages        = {{20}},
  title        = {{Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology}},
  url          = {{http://doi.org/10.1016/j.cocis.2021.101453}},
  volume       = {{54}},
  year         = {{2021}},
}
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