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Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds

Marjan Van Cleemput (UGent) , Ko Cattoor (UGent) , Karolien De Bosscher (UGent) , Guy Haegeman (UGent) , Denis De Keukeleire (UGent) and Arne Heyerick (UGent)
(2009) Journal of Natural Products. 72(6). p.1220-1230
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Abstract
Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds.

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Chicago
Van Cleemput, Marjan, Ko Cattoor, Karolien De Bosscher, Guy Haegeman, Denis De Keukeleire, and Arne Heyerick. 2009. “Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds.” Journal of Natural Products 72 (6): 1220–1230.
APA
Van Cleemput, M., Cattoor, K., De Bosscher, K., Haegeman, G., De Keukeleire, D., & Heyerick, A. (2009). Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds. Journal of Natural Products, 72(6), 1220–1230.
Vancouver
1.
Van Cleemput M, Cattoor K, De Bosscher K, Haegeman G, De Keukeleire D, Heyerick A. Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds. Journal of Natural Products. American Chemical Society and American Society of Pharmacognosy; 2009;72(6):1220–30.
MLA
Van Cleemput, Marjan, Ko Cattoor, Karolien De Bosscher, et al. “Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds.” Journal of Natural Products 72.6 (2009): 1220–1230. Print.
@article{872964,
  abstract     = {Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds.},
  author       = {Van Cleemput, Marjan and Cattoor, Ko and De Bosscher, Karolien and Haegeman, Guy and De Keukeleire, Denis and Heyerick, Arne},
  issn         = {0163-3864},
  journal      = {Journal of Natural Products},
  language     = {eng},
  number       = {6},
  pages        = {1220--1230},
  publisher    = {American Chemical Society and American Society of Pharmacognosy},
  title        = {Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds},
  url          = {http://dx.doi.org/10.1021/np800740m},
  volume       = {72},
  year         = {2009},
}

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