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Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds

Marjan Van Cleemput UGent, Ko Cattoor UGent, Karolien De Bosscher UGent, Guy Haegeman UGent, Denis De Keukeleire UGent and Arne Heyerick UGent (2009) Journal of Natural Products. 72(6). p.1220-1230
abstract
Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
journal title
Journal of Natural Products
J. Nat. Prod.
volume
72
issue
6
pages
1220 - 1230
publisher
American Chemical Society and American Society of Pharmacognosy
Web of Science type
Review
Web of Science id
000267432600046
JCR category
PLANT SCIENCES
JCR impact factor
3.159 (2009)
JCR rank
23/172 (2009)
JCR quartile
1 (2009)
ISSN
0163-3864
DOI
10.1021/np800740m
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
872964
handle
http://hdl.handle.net/1854/LU-872964
date created
2010-02-22 11:57:52
date last changed
2010-03-12 14:54:06
@article{872964,
  abstract     = {Hop acids, a family of bitter compounds derived from the hop plant (Humulus lupulus), have been reported to exert a wide range of effects, both in vitro and in vivo. They exhibit potential anticancer activity by inhibiting cell proliferation and angiogenesis, by inducing apoptosis, and by increasing the expression of cytochrome P450 detoxification enzymes. Furthermore, hop bitter acids are effective against inflammatory and metabolic disorders, which makes them challenging candidates for the treatment of diabetes mellitus, cardiovascular diseases, and metabolic syndrome. This review summarizes the current knowledge on hop bitter acids, including both phytochemical aspects, as well as the biological and pharmacological properties of these compounds.},
  author       = {Van Cleemput, Marjan and Cattoor, Ko and De Bosscher, Karolien and Haegeman, Guy and De Keukeleire, Denis and Heyerick, Arne},
  issn         = {0163-3864},
  journal      = {Journal of Natural Products},
  language     = {eng},
  number       = {6},
  pages        = {1220--1230},
  publisher    = {American Chemical Society and American Society of Pharmacognosy},
  title        = {Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds},
  url          = {http://dx.doi.org/10.1021/np800740m},
  volume       = {72},
  year         = {2009},
}

Chicago
Van Cleemput, Marjan, Ko Cattoor, Karolien De Bosscher, Guy Haegeman, Denis De Keukeleire, and Arne Heyerick. 2009. “Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds.” Journal of Natural Products 72 (6): 1220–1230.
APA
Van Cleemput, M., Cattoor, K., De Bosscher, K., Haegeman, G., De Keukeleire, D., & Heyerick, A. (2009). Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds. Journal of Natural Products, 72(6), 1220–1230.
Vancouver
1.
Van Cleemput M, Cattoor K, De Bosscher K, Haegeman G, De Keukeleire D, Heyerick A. Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds. Journal of Natural Products. American Chemical Society and American Society of Pharmacognosy; 2009;72(6):1220–30.
MLA
Van Cleemput, Marjan, Ko Cattoor, Karolien De Bosscher, et al. “Hop (Humulus lupulus)-Derived Bitter Acids as Multipotent Bioactive Compounds.” Journal of Natural Products 72.6 (2009): 1220–1230. Print.