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The variability in potential biomarkers for cochlear synaptopathy after recreational noise exposure

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Abstract
Purpose: Speech-in-noise tests and suprathreshold auditory evoked potentials are promising biomarkers to diagnose cochlear synaptopathy (CS) in humans. This study investigated whether these biomarkers changed after recreational noise exposure. Method: The baseline auditory status of 19 normal-hearing young adults was analyzed using questionnaires, pure-tone audiometry, speech audiometry, and auditory evoked potentials. Nineteen subjects attended a music festival and completed the same tests again at Day 1, Day 3, and Day 5 after the music festival. Results: No significant relations were found between lifetime noise-exposure history and the hearing tests. Changes in biomarkers from the first session to the follow-up sessions were nonsignificant, except for speech audiometry, which showed a significant learning effect (performance improvement). Conclusions: Despite the individual variability in prefestival biomarkers, we did not observe changes related to the noise-exposure dose caused by the attended event. This can indicate the absence of noise exposure–driven CS in the study cohort, or reflect that biomarkers were not sensitive enough to detect mild CS. Future research should include a more diverse study cohort, dosimetry, and results from test–retest reliability studies to provide more insight into the relationship between recreational noise exposure and CS.
Keywords
Speech and Hearing, Linguistics and Language, Language and Linguistics, BRAIN-STEM-RESPONSE, INDUCED HEARING-LOSS, TEMPORARY THRESHOLD SHIFT, LEISURE-NOISE, YOUNG-ADULTS, AUDITORY FUNCTION, RISK-FACTORS, TINNITUS, ENVELOPE, AGE

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Citation

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MLA
Vande Maele, Tine, et al. “The Variability in Potential Biomarkers for Cochlear Synaptopathy after Recreational Noise Exposure.” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, vol. 64, no. 12, 2021, pp. 4964–81, doi:10.1044/2021_jslhr-21-00064.
APA
Vande Maele, T., Keshishzadeh, S., De Poortere, N., Dhooge, I., Keppler, H., & Verhulst, S. (2021). The variability in potential biomarkers for cochlear synaptopathy after recreational noise exposure. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, 64(12), 4964–4981. https://doi.org/10.1044/2021_jslhr-21-00064
Chicago author-date
Vande Maele, Tine, Sarineh Keshishzadeh, Nele De Poortere, Ingeborg Dhooge, Hannah Keppler, and Sarah Verhulst. 2021. “The Variability in Potential Biomarkers for Cochlear Synaptopathy after Recreational Noise Exposure.” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH 64 (12): 4964–81. https://doi.org/10.1044/2021_jslhr-21-00064.
Chicago author-date (all authors)
Vande Maele, Tine, Sarineh Keshishzadeh, Nele De Poortere, Ingeborg Dhooge, Hannah Keppler, and Sarah Verhulst. 2021. “The Variability in Potential Biomarkers for Cochlear Synaptopathy after Recreational Noise Exposure.” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH 64 (12): 4964–4981. doi:10.1044/2021_jslhr-21-00064.
Vancouver
1.
Vande Maele T, Keshishzadeh S, De Poortere N, Dhooge I, Keppler H, Verhulst S. The variability in potential biomarkers for cochlear synaptopathy after recreational noise exposure. JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH. 2021;64(12):4964–81.
IEEE
[1]
T. Vande Maele, S. Keshishzadeh, N. De Poortere, I. Dhooge, H. Keppler, and S. Verhulst, “The variability in potential biomarkers for cochlear synaptopathy after recreational noise exposure,” JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH, vol. 64, no. 12, pp. 4964–4981, 2021.
@article{8729602,
  abstract     = {{Purpose: Speech-in-noise tests and suprathreshold auditory evoked potentials are promising biomarkers to diagnose cochlear synaptopathy (CS) in humans. This study investigated whether these biomarkers changed after recreational noise exposure.

Method: The baseline auditory status of 19 normal-hearing young adults was analyzed using questionnaires, pure-tone audiometry, speech audiometry, and auditory evoked potentials. Nineteen subjects attended a music festival and completed the same tests again at Day 1, Day 3, and Day 5 after the music festival.

Results: No significant relations were found between lifetime noise-exposure history and the hearing tests. Changes in biomarkers from the first session to the follow-up sessions were nonsignificant, except for speech audiometry, which showed a significant learning effect (performance improvement).

Conclusions: Despite the individual variability in prefestival biomarkers, we did not observe changes related to the noise-exposure dose caused by the attended event. This can indicate the absence of noise exposure–driven CS in the study cohort, or reflect that biomarkers were not sensitive enough to detect mild CS. Future research should include a more diverse study cohort, dosimetry, and results from test–retest reliability studies to provide more insight into the relationship between recreational noise exposure and CS.}},
  author       = {{Vande Maele, Tine and Keshishzadeh, Sarineh and De Poortere, Nele and Dhooge, Ingeborg and Keppler, Hannah and Verhulst, Sarah}},
  issn         = {{1092-4388}},
  journal      = {{JOURNAL OF SPEECH LANGUAGE AND HEARING RESEARCH}},
  keywords     = {{Speech and Hearing,Linguistics and Language,Language and Linguistics,BRAIN-STEM-RESPONSE,INDUCED HEARING-LOSS,TEMPORARY THRESHOLD SHIFT,LEISURE-NOISE,YOUNG-ADULTS,AUDITORY FUNCTION,RISK-FACTORS,TINNITUS,ENVELOPE,AGE}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{4964--4981}},
  title        = {{The variability in potential biomarkers for cochlear synaptopathy after recreational noise exposure}},
  url          = {{http://dx.doi.org/10.1044/2021_jslhr-21-00064}},
  volume       = {{64}},
  year         = {{2021}},
}

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