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Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy

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Abstract
Background: Immunogenic cell death (ICD) is a peculiar modality of cellular demise that elicits adaptive immune responses and triggers T cell-dependent immunity. Methods: Fluorescent biosensors were employed for an unbiased drug screen approach aiming at the identification of ICD enhancers. Results: Here, we discovered thiostrepton as an enhancer of ICD able to boost chemotherapy-induced ATP release, calreticulin exposure and high-mobility group box 1 exodus. Moreover, thiostrepton enhanced anticancer immune responses of oxaliplatin (OXA) in vivo in immunocompetent mice, yet failed to do so in immunodeficient animals. Consistently, thiostrepton combined with OXA altered the ratio of cytotoxic T lymphocytes to regulatory T cells, thus overcoming immunosuppression and reinstating anticancer immunosurveillance. Conclusion: Altogether, these results indicate that thiostrepton can be advantageously combined with chemotherapy to enhance anticancer immunogenicity.
Keywords
adaptive immunity, immunomodulation, CANCER, PROTEIN, DEATH, CELLS

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MLA
Wang, Yan, et al. “Autophagy Induction by Thiostrepton Improves the Efficacy of Immunogenic Chemotherapy.” JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 2020, doi:10.1136/jitc-2019-000462.
APA
Wang, Y., Xie, W., Humeau, J., Chen, G., Liu, P., Pol, J., … Kroemer, G. (2020). Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy. JOURNAL FOR IMMUNOTHERAPY OF CANCER, 8(1). https://doi.org/10.1136/jitc-2019-000462
Chicago author-date
Wang, Yan, Wei Xie, Juliette Humeau, Guo Chen, Peng Liu, Jonathan Pol, Zhen Zhang, Oliver Kepp, and Guido Kroemer. 2020. “Autophagy Induction by Thiostrepton Improves the Efficacy of Immunogenic Chemotherapy.” JOURNAL FOR IMMUNOTHERAPY OF CANCER 8 (1). https://doi.org/10.1136/jitc-2019-000462.
Chicago author-date (all authors)
Wang, Yan, Wei Xie, Juliette Humeau, Guo Chen, Peng Liu, Jonathan Pol, Zhen Zhang, Oliver Kepp, and Guido Kroemer. 2020. “Autophagy Induction by Thiostrepton Improves the Efficacy of Immunogenic Chemotherapy.” JOURNAL FOR IMMUNOTHERAPY OF CANCER 8 (1). doi:10.1136/jitc-2019-000462.
Vancouver
1.
Wang Y, Xie W, Humeau J, Chen G, Liu P, Pol J, et al. Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy. JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2020;8(1).
IEEE
[1]
Y. Wang et al., “Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy,” JOURNAL FOR IMMUNOTHERAPY OF CANCER, vol. 8, no. 1, 2020.
@article{8727751,
  abstract     = {{Background: Immunogenic cell death (ICD) is a peculiar modality of cellular demise that elicits adaptive immune responses and triggers T cell-dependent immunity.

Methods: Fluorescent biosensors were employed for an unbiased drug screen approach aiming at the identification of ICD enhancers.

Results: Here, we discovered thiostrepton as an enhancer of ICD able to boost chemotherapy-induced ATP release, calreticulin exposure and high-mobility group box 1 exodus. Moreover, thiostrepton enhanced anticancer immune responses of oxaliplatin (OXA) in vivo in immunocompetent mice, yet failed to do so in immunodeficient animals. Consistently, thiostrepton combined with OXA altered the ratio of cytotoxic T lymphocytes to regulatory T cells, thus overcoming immunosuppression and reinstating anticancer immunosurveillance.

Conclusion: Altogether, these results indicate that thiostrepton can be advantageously combined with chemotherapy to enhance anticancer immunogenicity.}},
  articleno    = {{e000462}},
  author       = {{Wang, Yan and Xie, Wei and Humeau, Juliette and Chen, Guo and Liu, Peng and Pol, Jonathan and Zhang, Zhen and Kepp, Oliver and Kroemer, Guido}},
  issn         = {{2051-1426}},
  journal      = {{JOURNAL FOR IMMUNOTHERAPY OF CANCER}},
  keywords     = {{adaptive immunity,immunomodulation,CANCER,PROTEIN,DEATH,CELLS}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{Autophagy induction by thiostrepton improves the efficacy of immunogenic chemotherapy}},
  url          = {{http://doi.org/10.1136/jitc-2019-000462}},
  volume       = {{8}},
  year         = {{2020}},
}

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