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The Flo adhesin family

Ronnie G. Willaert, Yeseren Kayacan (UGent) and Bart Devreese (UGent)
(2021) PATHOGENS. 10(11).
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Abstract
The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.
Keywords
Infectious Diseases, Microbiology (medical), General Immunology and Microbiology, Molecular Biology, Immunology and Allergy, Flo adhesin family, pathogenic yeasts, Candida glabrata, Saccharomyces cerevisiae, host-pathogen interaction, abiotic surface adhesion, adhesin structure, adhesin architecture, BLOOD-STREAM INFECTION, CELL-SURFACE HYDROPHOBICITY, GLOBAL ANTIFUNGAL SURVEILLANCE, POPULATION-BASED SURVEILLANCE, RESISTANT CANDIDA-AURIS, CRITICALLY-ILL PATIENTS, INTENSIVE-CARE-UNIT, N-TERMINAL DOMAIN, SACCHAROMYCES-CEREVISIAE, BIOFILM FORMATION

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Citation

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MLA
Willaert, Ronnie G., et al. “The Flo Adhesin Family.” PATHOGENS, vol. 10, no. 11, 2021, doi:10.3390/pathogens10111397.
APA
Willaert, R. G., Kayacan, Y., & Devreese, B. (2021). The Flo adhesin family. PATHOGENS, 10(11). https://doi.org/10.3390/pathogens10111397
Chicago author-date
Willaert, Ronnie G., Yeseren Kayacan, and Bart Devreese. 2021. “The Flo Adhesin Family.” PATHOGENS 10 (11). https://doi.org/10.3390/pathogens10111397.
Chicago author-date (all authors)
Willaert, Ronnie G., Yeseren Kayacan, and Bart Devreese. 2021. “The Flo Adhesin Family.” PATHOGENS 10 (11). doi:10.3390/pathogens10111397.
Vancouver
1.
Willaert RG, Kayacan Y, Devreese B. The Flo adhesin family. PATHOGENS. 2021;10(11).
IEEE
[1]
R. G. Willaert, Y. Kayacan, and B. Devreese, “The Flo adhesin family,” PATHOGENS, vol. 10, no. 11, 2021.
@article{8725687,
  abstract     = {{The first step in the infection of fungal pathogens in humans is the adhesion of the pathogen to host tissue cells or abiotic surfaces such as catheters and implants. One of the main players involved in this are the expressed cell wall adhesins. Here, we review the Flo adhesin family and their involvement in the adhesion of these yeasts during human infections. Firstly, we redefined the Flo adhesin family based on the domain architectures that are present in the Flo adhesins and their functions, and set up a new classification of Flo adhesins. Next, the structure, function, and adhesion mechanisms of the Flo adhesins whose structure has been solved are discussed in detail. Finally, we identified from Pfam database datamining yeasts that could express Flo adhesins and are encountered in human infections and their adhesin architectures. These yeasts are discussed in relation to their adhesion characteristics and involvement in infections.}},
  articleno    = {{1397}},
  author       = {{Willaert, Ronnie G. and Kayacan, Yeseren and Devreese, Bart}},
  issn         = {{2076-0817}},
  journal      = {{PATHOGENS}},
  keywords     = {{Infectious Diseases,Microbiology (medical),General Immunology and Microbiology,Molecular Biology,Immunology and Allergy,Flo adhesin family,pathogenic yeasts,Candida glabrata,Saccharomyces cerevisiae,host-pathogen interaction,abiotic surface adhesion,adhesin structure,adhesin architecture,BLOOD-STREAM INFECTION,CELL-SURFACE HYDROPHOBICITY,GLOBAL ANTIFUNGAL SURVEILLANCE,POPULATION-BASED SURVEILLANCE,RESISTANT CANDIDA-AURIS,CRITICALLY-ILL PATIENTS,INTENSIVE-CARE-UNIT,N-TERMINAL DOMAIN,SACCHAROMYCES-CEREVISIAE,BIOFILM FORMATION}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{39}},
  title        = {{The Flo adhesin family}},
  url          = {{http://doi.org/10.3390/pathogens10111397}},
  volume       = {{10}},
  year         = {{2021}},
}
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